Transmission-mode direct analysis in real time and desorption electrospray ionization mass spectrometry of insecticide-treated bednets for malaria control

Perez, Jonas W.; Harris, Geoffrey; Chipuk, Joseph E.; Brodbelt, Jennifer S.; Green, Michael D.; Hampton, Christina Y.; Fernández, Facundo M.

doi:10.1039/b924533b

Cited by 71 publications

(72 citation statements)

References 29 publications

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“…The Open Source assembly consists of a card holder frame located beneath a compact hood, and makes use of disposable cardboard sample holders. The sample is desorbed after deposition on a fine metal wire mesh [33][34][35]. External mass calibration in positive-ion DART mode was established on either silicone oil (VWR Silikonöl 47 V 350; VWR International GmbH, Bruchsal, Germany) [31] or 1-butyl-3-methylimidazolium tricyanomethide (Merck KGaA, Darmstadt, Germany), an ionic liquid (IL) [36], both employed as solutions at 1 mg mL…”

Section: Dart Setupmentioning

confidence: 99%

Analysis of Silicones Released from Household Items and Baby Articles by Direct Analysis in Real Time-Mass Spectrometry

Gross

2014

J. Am. Soc. Mass Spectrom.

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Abstract. Direct analysis in real time-mass spectrometry (DART-MS) enables screening of articles of daily use made of polydimethylsiloxanes (PDMS), commonly known as silicone rubber, to assess their tendency to release low molecular weight silicone oligomers. DART-MS analyses were performed on a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. Flexible silicone baking molds, a watch band, and a dough scraper, as baby articles different brands of pacifiers, nipples, and a teething ring have been examined. While somewhat arbitrarily chosen, the set can be regarded as representative of household items, baby articles, and other objects made of silicone rubber. For comparison, two brands of silicone septa and as blanks a glass slide and a latex pacifier were included. Differences between the objects were mainly observed in terms of molecular weight distribution and occasional release of other compounds in addition to PDMS. Other than that, all objects made of silicone rubber released significant amounts of PDMS during DART analysis. To provide a coarse quantification, a calibration based on silicone oil was established, which delivered PDMS losses from 20 μg to 9100 μg during the 16-s period per measurement. Also, the extraction of baking molds in rapeseed oil demonstrated a PDMS release at the level of 1 μg mg -1 . These findings indicate a potential health hazard from frequent or long-term use of such items. This work does not intend to blame certain brands of such articles. Nonetheless, a higher level of awareness of this source of daily silicone intake is suggested.

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Section: Dart Setupmentioning

confidence: 99%

Analysis of Silicones Released from Household Items and Baby Articles by Direct Analysis in Real Time-Mass Spectrometry

Gross

2014

J. Am. Soc. Mass Spectrom.

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“…In this approach, a multitude of geometric variables affect analyte desorption, ion transmission, and the reproducibility of the experiments, as the sample capillary itself creates turbulence while being introduced into the ionization region [25]. To minimize the variances introduced by the DM's geometry factors, the Transmission Module (TM)-DART, originally reported by Perez et al [26] was used as an alternative. TM operation is highly advantageous as the sample can be deposited directly on a stainless steel mesh that is held in the ionization region by a programmable linear rail placed directly between the ion source and the mass spectrometer inlet.…”

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confidence: 99%

Determination of Dicyandiamide in Powdered Milk Using Direct Analysis in Real Time Quadrupole Time-of-Flight Tandem Mass Spectrometry

Zhang

Yong

Liu

et al. 2015

J. Am. Soc. Mass Spectrom.

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MS DART DCDAbstract. The direct analysis in real time (DART) ionization source coupled with quadrupole time-of-flight tandem mass spectrometry (Q-TOF MS/MS) system has the capability to desorb analytes directly from samples without sample cleanup or chromatographic separation. In this work, a method based on DART/Q-TOF MS/MS has been developed for rapid identification of dicyandiamide (DCD) present in powdered milk. Simple sample extraction procedure employing acetonitrile-water (80:20, v/v) mixture was followed by direct, high-throughput determination of sample extracts spread on a steel mesh of the transmission module by mass spectrometry under ambient conditions. The method has been evaluated for both qualitative and quantitative analysis of DCD in powdered milk. Variables including experimental apparatus, DART gas heater temperature, sample presentation speed, and vacuum pressure were investigated. The quantitative method was validated with respect to linearity, sensitivity, repeatability, precision, and accuracy by using external standards. After optimization of these parameters, a limit of detection (LOD) of 100 μg kg -1 was obtained for DCD with a linear working range from 100 to 10000 μg kg -1 and a satisfactory correlation coefficient (R 2 ) of 0.9997. Good recovery (80.08%-106.47%) and repeatability (RSD=3.0%-5.4%) were achieved for DCD. The DART/Q-TOF MS/MS-based method provides a rapid, efficient, and powerful scheme to analyze DCD in powdered milk with limited sample preparation, thus reducing time and complexity of quality control.

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“…27) Transmission DART, in which the gas passes through a screen, minimizes turbulence and improves quantitation. 28) A gas transfer tube with vacuum assist also improves the reproducibility of sampling. 29) A useful approach combining transmission DART with resistive heating 30) and a gas transfer tube is now commercially available from the manufacturer of the DART (Ionsense, Saugus, MA, USA).…”

Section: Resultsmentioning

confidence: 99%

What Is the Opposite of Pandora’s Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources

Cody

2013

Mass Spectrometry

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The introduction of DART and DESI sources approximately seven years ago led to the development of a new series of atmospheric pressure ion sources referred to as "ambient ionization" sources. These fall into two major categories: spray techniques like DESI or plasma techniques like DART. The selectivity of "direct ionization," meaning analysis without chromatography and with little or no sample preparation, depends on the mass spectrometer selectivity. Although high resolution and tandem mass spectrometry are valuable tools, rapid and simple sample preparation methods can improve the utility of ambient ionization methods. The concept of ambient ionization has led to the realization that there are many more ways to form ions than might be expected. An interesting example is the use of a flint-and-steel spark source to generate ions from compounds such as phenolphthalein and Gramicidin S.

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Transmission-mode direct analysis in real time and desorption electrospray ionization mass spectrometry of insecticide-treated bednets for malaria control

Cited by 71 publications

References 29 publications

Analysis of Silicones Released from Household Items and Baby Articles by Direct Analysis in Real Time-Mass Spectrometry

Analysis of Silicones Released from Household Items and Baby Articles by Direct Analysis in Real Time-Mass Spectrometry

Determination of Dicyandiamide in Powdered Milk Using Direct Analysis in Real Time Quadrupole Time-of-Flight Tandem Mass Spectrometry

What Is the Opposite of Pandora’s Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources

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