Transplant Antigen Biology

Rajalingam, Raja; Zhang, Qiuheng; Cecka, J. Michael; Reed, Elaine F.

doi:10.1002/9781118873434.ch4

Cited by 1 publication

(1 citation statement)

References 113 publications

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“…Their proximity causes all loci undergo low recombination rates during meiosis (linkage disequilibrium), thus these genes are inherited as a haplotype. 8 The quaternary structure of class I has been displayed as polypeptide (α chain) associated with β 2 microglobulin (nonpolymorphic), which is coded in another chromosome. The HLA class I (A-C) appears in all nucleated cells; in addition, there are other loci expressed on few cells (E, F, G) with specialized functions.…”

Section: Mhc Role In the Organ Rejectionmentioning

confidence: 99%

Transplant immunology I: mechanisms of rejection in solid organ transplants

Fernández¹,

Delgado²,

Amador³

2022

JSRT

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Non-identical transplants (allogeneic) have been a modern medicine milestone; however, the major pitfall for completed succeed is the recognition of foreign organ by the immune system. The myriad variations in sequence of the molecules of the major histocompatibility complex (MHC) or human leukocyte antigen (HLA) between individuals are the major cause of allograft rejection. Thus, the recognition by the B or T lymphocytes of the receptor occurs in the hypervariable regions of the HLA molecules that triggers to the graft 3 types of rejection: hyperacute, acute, and chronic. In addition, the rejection could be cause antibody-mediated (ABMR), T-cell-mediated (TCMR), or both, which depends on the main branch is cause of rejection. This review will explore the mechanisms mentioned above and give an introductory insight into transplant immunology; thus, preparer the reader to delve into further reviews in a Histocompatibility or Immunogenetics laboratory purpose.

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Section: Mhc Role In the Organ Rejectionmentioning

confidence: 99%