Transplanted fat adapts to the environment of the recipient: An animal study using a murine model to investigate the suitability of recipient obesity mismatch in face transplantation

Suchyta, Marissa; Gibreel, Waleed; Bakri, Karim; Amer, Hatem; Mardini, Samir

doi:10.1016/j.bjps.2019.06.021

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The perigonadal fat pad was used as the donor site because of its high white adipose cell count. [15][16][17][18] To access perigonadal fat, the donor site was shaved and a 2-to 3-cm skin incision was made 5 cm above both testicles after field sterilization. The anterior abdominal wall muscles and their aponeuroses were elevated and incised again with scissors to elevate the perigonadal fat pad (Fig.…”

Section: Surgical Techniquementioning

confidence: 99%

Increased Total Antioxidant Capacity Value Improves Survival of Fat Grafts in Rat Model

Cinar

Yalcin

Ayas

et al. 2023

Plastic &Amp; Reconstructive Surgery

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Background: While studies aiming to increase fat graft survival continue, in this study, we aimed to investigate the effects of different antioxidants on total antioxidant capacity and their effect on graft survival. Methods: Thirty-two male Wistar rats were divided into four equally sized groups, including a control group and three antioxidant groups receiving either Melatonin (10mg/kg), Zinc (2mg/kg), or Vitamin E and C (100mg/kg). Autologous fat grafts (1.7± 0.4gr) were transferred to the dorsal subcutaneous region, and total antioxidant capacity was measured on day 0 and 1, week 1 and monthly until the third month. Transferred graft volume and mass (1.3± 0.4gr) were measured using the liquid overflow method and precision scales at the end of the study. Routine hematoxylin-eosin staining and immunohistochemistry against perilipin were performed for semiqualitative analysis and h-score for viable adipose cells, respectively. Results: Collected fat grafts measured significantly less in weight and volume and the survival rate was lower in the control group (p<0.01). Control group exhibited a reduction in TAC, while all groups receiving antioxidants had an increase in TAC during the first week (p=0.02, 0.008, and 0.004 for melatonin, zinc, and vitamins, respectively). Immunohistochemistry of the antioxidant group demonstrated a statistically significant excess and reactivity of cells staining with perilipin antibodies. Conclusions: In this animal study, the beneficial effect of antioxidants on fat graft survival can be related to the significant increase in TAC following the first week of their administration.

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Section: Surgical Techniquementioning

confidence: 99%

Increased Total Antioxidant Capacity Value Improves Survival of Fat Grafts in Rat Model

Cinar

Yalcin

Ayas

et al. 2023

Plastic &Amp; Reconstructive Surgery

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“…24 Supplementing composite tissue allografts with stem cell therapies-specifically, adipose tissue versus bone marrow-derived stem cells-has been studied in broad basic science applications 45,46 and more recently in plastic surgery applications. 47,48 Together, both stromal vascular fraction-and adipose-derived stem cellmediated therapies have shown improvements in graft neovascularization, immune modulation, and induction of peripheral tolerance in transplantation applications, reviewed here. 49 Recent evidence in ex vivo adipose-derived stem cell culture demonstrated that hypoxic conditions enhanced their regenerative potential.…”

Section: Adipose-derived Stem Cell-guided Immunomodulation Promotes W...mentioning

confidence: 99%

Update on the Basic Science Concepts and Applications of Adipose-Derived Stem Cells in Hand and Craniofacial Surgery

Lynch

Anderson

DeCoster

et al. 2021

Plastic &Amp; Reconstructive Surgery

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tem cells possess both an innate capacity for self-renewal and the ability to replace more specialized cells lost after injury. 1 Multiple types of stem cells have been described, but only embryonic stem cells exhibit native pluripotency across all three germ layers. 2 However, isolating embryonic stem cells presents significant ethical challenges, as harvest invariably leads to demise of the embryo. Conversely, adult stem cells are multipotent stem cells capable of differentiating within a single germ layer. 3 Generating large quantities of inducible, multipotent adult stem cells will revolutionize regenerative medicine applications, including plastic surgery, but the scientific and ethical basis of this practice remains unclear. Mesenchymal stem cells are a promising subclass of adult stem cells found within adipose tissue (adipose-derived stem cells) and bone marrow (bone marrow-derived stem cells). 4 With broad differentiation potential (Fig. 1), 5 and fewer ethical concerns surrounding their use, adipose-derived stem cells and bone marrow-derived stem cells have enjoyed clinical utility for the treatment of

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Facial Transplantation

Bakri¹,

Gibreel²,

Cotofana³

et al. 2022

Facial Plastic Surgery Clinics of North America

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Transplanted fat adapts to the environment of the recipient: An animal study using a murine model to investigate the suitability of recipient obesity mismatch in face transplantation

Cited by 3 publications

References 23 publications

Increased Total Antioxidant Capacity Value Improves Survival of Fat Grafts in Rat Model

Increased Total Antioxidant Capacity Value Improves Survival of Fat Grafts in Rat Model

Update on the Basic Science Concepts and Applications of Adipose-Derived Stem Cells in Hand and Craniofacial Surgery

Facial Transplantation

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