Transport Barriers Influence the Activation of Anti‐Tumor Immunity: A Systems Biology Analysis
Mohammad R. Nikmaneshi,
James W. Baish,
Hengbo Zhou
et al.
Abstract:Effective anti‐cancer immune responses require activation of one or more naïve T cells. If the correct naïve T cell encounters its cognate antigen presented by an antigen presenting cell, then the T cell can activate and proliferate. Here, mathematical modeling is used to explore the possibility that immune activation in lymph nodes is a rate‐limiting step in anti‐cancer immunity and can affect response rates to immune checkpoint therapy. The model provides a mechanistic framework for optimizing cancer immunot… Show more
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