Transspinal constant-current long-lasting stimulation: a new method to induce cortical and corticospinal plasticity

Knikou, Maria; Dixon, Luke; Santora, Danielle; Ibrahim, Mohamed F.

doi:10.1152/jn.00449.2015

Cited by 42 publications

(53 citation statements)

References 85 publications

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“…; Knikou et al . ). However, they may well reflect differences in the current density and its gradient within the spinal cord in conditions of tsDCS.…”

Section: Discussionmentioning

confidence: 97%

“…; Knikou et al . ). However, marked post‐activation depression in pathways between cutaneous afferents and dorsal horn neurons (Hammar et al .…”

Section: Discussionmentioning

confidence: 97%

“…; Knikou et al . ) and responses to stimulation of skin afferents after spinal cord injury (Hubli et al . ), and primarily in healthy subjects (see Priori et al .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does trans‐spinal and local DC polarization affect presynaptic inhibition and post‐activation depression?

Kaczmarek

Ristikankare

Jankowska

2017

The Journal of Physiology

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Direct current (DC) polarization has been demonstrated to alleviate the effects of various deficits in the operation of the central nervous system. However, the effects of trans-spinal DC stimulation (tsDCS) have been investigated less extensively than the effects of transcranial DC stimulation, and their cellular mechanisms have not been elucidated. The main objectives of this study were, therefore, to extend our previous analysis of DC effects on the excitability of primary afferents and synaptic transmission by examining the effects of DC on two spinal modulatory feedback systems, presynaptic inhibition and post-activation depression, in an anaesthetized rat preparation. Other objectives were to compare the effects of locally and trans-spinally applied DC (locDC and tsDCS). Local polarization at the sites of terminal branching of afferent fibres was found to induce polarity-dependent actions on presynaptic inhibition and post-activation depression, as cathodal locDC enhanced them and anodal locDC depressed them. In contrast, tsDCS modulated presynaptic inhibition and post-activation depression in a polarity-independent fashion because both cathodal and anodal tsDCS facilitated them. The results show that the local presynaptic actions of DC might counteract both excessively strong and excessively weak monosynaptic actions of group Ia and cutaneous afferents. However, they indicate that trans-spinally applied DC might counteract the exaggerated spinal reflexes but have an adverse effect on pathologically weakened spinal activity by additional presynaptic weakening. The results are also relevant for the analysis of the basic properties of presynaptic inhibition and post-activation depression because they indicate that some common DC-sensitive mechanisms contribute to them.

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“…; Knikou et al . ). However, they may well reflect differences in the current density and its gradient within the spinal cord in conditions of tsDCS.…”

Section: Discussionmentioning

confidence: 97%

“…; Knikou et al . ). However, marked post‐activation depression in pathways between cutaneous afferents and dorsal horn neurons (Hammar et al .…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Does trans‐spinal and local DC polarization affect presynaptic inhibition and post‐activation depression?

Kaczmarek

Ristikankare

Jankowska

2017

The Journal of Physiology

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“…Another promising NIBS technique involves the delivery of 40 min of constant current stimulation to the spinal cord [106]. Long-lasting transspinal constant current stimulation (ts-CCS) alters cortical, corticospinal, and spinal plasticity in uninjured participants.…”

Section: New Opportunities For Nibs To Promote Motor Recovery In Scimentioning

confidence: 99%

“…Long-lasting transspinal constant current stimulation (ts-CCS) alters cortical, corticospinal, and spinal plasticity in uninjured participants. Knikou et al [106] found that both cathodal tsCCS and anodal tsCCS decreased afferent-mediated MEP facilitation, increased MEP amplitudes, and decreased transspinal-evoked potentials (TEPs) of knee flexors. Further, cathodal tsCCS increased TMS-mediated tibialis anterior flexor reflex facilitation, while anodal tsCCS decreased TMS-mediated TA flexor reflex facilitation and decreased post-activation depression of TEPs for the soleus H-reflex.…”

Section: New Opportunities For Nibs To Promote Motor Recovery In Scimentioning

confidence: 99%

Non-invasive Brain Stimulation to Characterize and Alter Motor Function after Spinal Cord Injury

Bailey¹,

Fassett²,

Lulic³

et al. 2016

Recovery of Motor Function Following Spinal Cord Injury

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Abstract"dvances in transcranial magnetic stimulation TMS now permit the precise assessment of circuitry in human motor cortices that contribute to movement. Further, TMS approaches are used to promote neural plasticity within cortical and spinal circuitry in an attempt to create short-term changes in motor control. This review is focused on the application of TMS techniques in the study of characterizing and promoting neural plasticity within individuals presenting with chronic spinal cord injury. We review TMS research performed in individuals with SCI and consider new opportunities for the use of TMS approaches to promote neural plasticity for improving motor recovery.

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Repeated cathodal transspinal pulse and direct current stimulation modulate cortical and corticospinal excitability differently in healthy humans

Murray

Knikou

2019

Exp Brain Res

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Transspinal constant-current long-lasting stimulation: a new method to induce cortical and corticospinal plasticity

Abstract: Knikou M, Dixon L, Santora D, Ibrahim MM. Transspinal constant-current long-lasting stimulation: a new method to induce cortical and corticospinal plasticity.

Cited by 42 publications

References 85 publications

Does trans‐spinal and local DC polarization affect presynaptic inhibition and post‐activation depression?

Does trans‐spinal and local DC polarization affect presynaptic inhibition and post‐activation depression?

Non-invasive Brain Stimulation to Characterize and Alter Motor Function after Spinal Cord Injury

Repeated cathodal transspinal pulse and direct current stimulation modulate cortical and corticospinal excitability differently in healthy humans

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