Transurethral endoscopic submucosal en bloc dissection for nonmuscle invasive bladder cancer: A comparison study of HybridKnife-assisted versus conventional dissection technique

Cheng, Yongyi; Sun, Yuejun; Li, Jing; Liang, Liang; Zou, Tiejun; Qu, Weixing; Jiang, Yazhuo; Ren, Wei; Du, Changqing; Du, Shuangkuan; Zhao, Wencai

doi:10.4103/jcrt.jcrt_786_17

Cited by 27 publications

(34 citation statements)

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“…The bladder detrusor muscle in the specimen was showed in 4 articles [14,18,20,21]. Although there were 94% and 86.9% positive rate in EBRT and CTURBT group, respectively, no significant difference was found between two groups[OR, 3.59;95% [Cl], 0.6 to 21.63; p=0.16] ( Table 2).…”

Section: Bladder Detrusor Musclementioning

confidence: 96%

“…Fig.1 summarized the inclusion process. We performed intravesical chemotherapy or Bacille Calmette-Guerin BCG for postoperative patients, mitomycin was used in 5 studies [8,9,[15][16][17], epirubicin was used in 7 studies [6,7,10,12,14,23,24], pirarubicin was used in 5 studies [13,18,[20][21][22], BCG was used in 1 study [11] and BCG combined epirubicin [19] was used in 1 study.…”

Section: Eligible Studies and Characteristicsmentioning

confidence: 99%

“…Furthermore, 11 non-randomised studies [6,8,9,11,[15][16][17][20][21][22]24] were considered of high quality due to the score ≥7 stars ( Table 2). While there was a high heterogeneity in all comparisons, which may come from the patient demographics, difference in types of surgery and tumor characteristics.…”

Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

“…Where reported, the main intraoperative and postoperative side effects included: obturator nerve reflex [7][8][9][10]12,13,15,[17][18][19][20][21][22][23][24], bladder perforation [6-10, 13,15,16,18,20-24], bladder irritation [6,7,9,16], urethral stricture, bleeding and fever [6,7,9,[14][15][16]20,21,24]…”

Section: Complicationsmentioning

confidence: 99%

“…HybridKnife, needle electrode and laser are the main methods for EBRT. A series of studies comparing EBRT and CTURBT have been reported [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Although the clinical recurrence rate between two approaches is controversial, less intraoperative and postoperative complications have been observed when undergoing EBRT.…”

Section: Introductionmentioning

confidence: 99%

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Safety and efficacy of en bloc transurethral resection versus conventional transurethral resection for primary nonmuscle-invasive bladder cancer：a meta-analysis

Dong

Yao

et al. 2019

Preprint

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Background: The purpose of this meta-analysis is to compare the safety and efficacy of en bloc transurethral resection of bladder tumor（EBRT） versus conventional transurethral resection of bladder tumor（CTURBT）. Methods: We performed a meta-analysis of relevant articles through January 2019 using PubMed, Embase and Cochrane Central Register to compare the safety and efficacy of EBRT versus CTURBT. The main endpoint included the operation time（OT）, hospitalization time（HT）, catheterization time（AT），perioperative period complications, bladder detrusor muscle found in the specimen, the residual tumor on the base, the ratio of the same site recurrence and 12/24/36-month recurrence rate. Cochrane Collaboration’s Revman software, version 5.3, was used for statistical analysis. Results: A total of 19 studies with 2651 patients were included，1369 underwent EBRT and 1282 underwent CTURBT. Patients treated with EBRT had a significantly lower AT, HT, obturator nerve reflex, bladder perforation, bladder irritation, postoperative complications and 24-month recurrence rate than those who underwent CTURBT. While no significant difference was found in terms of OT, the ratio of bladder detrusor muscle found in the specimen, the residual tumor on the base, 12-month recurrence rate, 36-month recurrence rate and the ratio of the same site recurrence. In mitomycin subgroup, EBRT was superior to CTURBT in terms of 12/24-month recurrence rate. Similarly, in the prospective subgroup and retrospective subgroup, EBRT had a lower 24-month recurrence rate than CTURBT. However, no significant difference was found in the low, intermediate and high-risk group in the light of 12-36 month recurrence rate. Conclusions: Based on the included 19 articles, EBRT had a significantly lower AT, HT, intraoperative and postoperative complications and 24-month recurrence rate than those treated with CTURBT. Well designed randomized controlled trials were needed to reevaluate these outcomes. Trial registration: This meta-analysis was reported in agreement with the PRISMA statement and was registered on PROSPERO 2019CRD42019121673. Keywords: bladder tumor; en bloc transurethral resection; conventional transurethral resection of bladder tumor; meta-analysis; complication

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Section: Bladder Detrusor Musclementioning

confidence: 96%