Trapa natans L. root extract suppresses hyperglycemic and hepatotoxic effects in STZ-induced diabetic rat model

Kharbanda, Chetna; Alam, Mohammad Sarwar; Hamid, Hinna; Bano, Sameena; Haider, Saqlain; Nazreen, Syed; Ali, Yakub; Javed, Kalim

doi:10.1016/j.jep.2013.12.007

Cited by 34 publications

(18 citation statements)

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“…The decreased activity of endogenous antioxidant enzymes (SOD and CAT) also causes initiation and propagation of LPO. An increased oxidative stress leads to the rise in LPO level and it is associated with an elevation in BGL (Singh & Kakkar 2009;Kharbanda et al 2014). Decreased MDA level in EFSD (200, 400 and 800 mg/kg b.wt) treated groups show the reversal of LPO level that supports the antioxidant activity of EFSD in STZ À NA-induced diabetic rats.…”

Section: Discussionsupporting

confidence: 59%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

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Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant activities of ethanol extract of S. densiflorum (EFSD) fruits in streptozotocin (STZ) and nicotinamide (NA)-induced diabetic rats. Materials and methods Acute oral toxicity and oral glucose tolerance were assessed in normal rats. The antidiabetic, antihyperlipidaemic and antioxidant activities were investigated in STZ À NAinduced diabetic rats. Diabetic rats were orally administered with glibenclamide (10 mg/kg b.wt), EFSD (200, 400 and 800 mg/kg b.wt) for 28 d. Further, changes in the blood glucose level (BGL), biochemical parameters, antioxidants were observed and histology of pancreas was performed.Results No toxicity and lethality were observed. Results of the following parameters are represented by treated versus disease control (STZ + NA) groups. BGL (161.33 ± 22.8 versus 476.17 ± 56.58 mg/dl), glycosylated haemoglobin (5.285 ± 0.19 versus 8.05 ± 0.55%), urea (40.32 ± 1.96 versus 75.37 ± 2.91 mg/dl), uric acid (1.2 ± 0.07 versus 2.16 ± 0.05 mg/dl), total cholesterol (89.3 ± 5.14 versus 139.7 ± 5.95 mg/dl) and triglycerides (79.65 ± 2.52 versus 108.9 ± 3.61 mg/dl) were significantly decreased, whereas haemoglobin (11.75 ± 0.73 versus 7.95 ± 0.42 g/dl), high-density lipoprotein cholesterol (14.2 ± 1.11 versus 6.97 ± 0.84 mg/dl), total protein (45%) and liver glycogen (87%) were significantly increased in EFSD-treated diabetic group. Significant changes were observed in the enzymatic and non-enzymatic antioxidants in EFSDtreated groups (p50.001). Histopathological examination showed the regeneration of b-cells in Islets of Langerhans. Conclusion This study confirms the antidiabetic, antihyperlipidaemic and antioxidant activities of S. densiflorum fruits. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 59%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

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“…12 It was found that the results of both the studies are in concurrence. The change in plasma glucose level on 7th and 15th day of study was assessed and given in Figure 3.…”

Section: Introductionmentioning

confidence: 74%

Novel benzenesulfonylureas containing thiophenylpyrazoline moiety as potential antidiabetic and anticancer agents

Kharbanda

Alam

Hamid

et al. 2014

Bioorganic & Medicinal Chemistry Letters

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“…Temporary and generally reversible elevated liver enzymes (LDH, AST, ALT and GGT) may take place in up to 15% of patients who receive acitretin. 3,5 Elevated serum alkaline phosphatase (10% to 25%) and direct serum bilirubin (10% to 25%) have been also reported. Acitretin should be disinterested, in the case of toxic hepatic injury during treatment and further examination should be considered.…”

Section: Introductionmentioning

confidence: 99%

“…2 Pseudo-tumor cerebri is a very rare serious side-effect and acitretin should be discontinued rapidly if the patient experiences relentless, headache, nausea, vomiting and visual disturbance, and neurological assessment performed. 3,4 Moreover, vulvovaginitis due to candida has been reported as a rare side effect of this drug. 5,6 Increased sensitivity to insulin and hypoglycaemia, are seen in diabetic patients during retinoids utilization.…”

Section: Introductionmentioning

confidence: 99%

Severe Hepatotoxic Injury and Cirrhosis Due to Acitretin

Mokhtare¹

2017

JLRDT

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We report a case of 48year old man presented with icter, itching and nausea and vomiting. He had developed a severe hepatotoxic reaction, after treatment with acitretin (oral retinoid, which is the derivative of etretinate). Histological findings showed the development of liver fibrosis and cirrhosis. Elevated serum aminotransferase levels, which are usually reversible, have been reported during treatment with acitretin, however; the present study indicates a warning message that severe hepatotoxic injury may follow this treatment. Ab, HCV Ab, HIV Ab1, 2, Anti HSV Ab, Anti EBV Ab, Anti VZV Ab, Anti CMV Ab) with negative results and the other laboratory investigations such as; Antinuclear Ab, ASMA, Anti-LKM Ab, serum protein electerophoresis, Ferritin, Anti-mitochondrial Ab, P-ANCA, ASCA, IgG4, TSH, Anti-tissue transglutaminase IgG and IgA Ab) with normal range results. LDH and liver enzyme were decreased during hospital course without any significant change in ALP and Bilirubin level. KeywordsUpper endoscopy was done with normal results. Magnetic Resonance Cholangiopancreatography (MRCP) was done with the result of periportal and pericholecystic edema and decreased intrahepatic bile ducts diameter due to parenchymal hepatic edema. The other parts were normal according to the report (Figure 1). Figure 1Periportal and pericholecystic edema were found, the diameter of intrahepatic bile ducts was less than normal and pruned that could be due to parenchymal hepatic edema.Finally, liver biopsy was done .The sample was stained with Hematoxylin, and Eosin, Trichrome and Reticulin. Extensive lobular architecture disarray with marked necro-inflammatory changes of parenchyma characterized by obvious hydropic changes and single cell necrosis of hepatocytes as well as infiltration of mixed inflammatory cells was shown in Hematoxylin, and Eosin staining (Figure 2). Collapse of reticulin network associated with psuedolobule formation as well as portal fibrosis was shown in Reticulin and MassonTrichrome staining (Figure 3,4). Overall findings were in favor of an acute/sub acute liver injury according to Modified HAI score grade: 14/18, stage: 3/6. The patient with the diagnosis of acitretin induced cirrhosis was referred to liver transplantation clinic. After one week admission course the patient was discharged with relative symptome relief and was requested for monthly follow-up .Five months later in monthly follow-up visit ,these data was found; AST=31U/L(12- Liver fibroscan (Fibroscan model 502 touch, Echosence France, Paris) was done 5months later that revealed fibrosis score of F3 (10.1kPa) based on metavir histological index, and steatosis score of 332 (dB/m) which is equal to 80% steatosis, S3 stage. We followed the patient for 9months without any change in general clinical condition and liver function tests. DiscussionThe American Academy of Dermatology suggests a protocol for monitoring of these patients, as follows: CBC and renal function tests (baseline and then every 12weeks); lipid profile BS in diabetic p...

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Trapa natans L. root extract suppresses hyperglycemic and hepatotoxic effects in STZ-induced diabetic rat model

Cited by 34 publications

References 21 publications

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Novel benzenesulfonylureas containing thiophenylpyrazoline moiety as potential antidiabetic and anticancer agents

Severe Hepatotoxic Injury and Cirrhosis Due to Acitretin

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