Tratamento da anemia ferropriva com ferro quelato glicinato e crescimento de crianças na primeira infância

Ribeiro, Luciana Cisoto; Sigulem, Dirce Maria

doi:10.1590/s1415-52732008000500001

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…Ribeiro and Sigulem supplemented anemic children between 6 and 36 months with 5 mg/kg/d of iron as bis-glycinate chelate [ 36 ] and found a significant increase in the Hb concentration; however, ferritin concentration was not measured. Pineda and Ashmead supplemented children with anemia and malnutrition between 6 to 36 months of age with ferrous sulfate versus iron bis-glycinate chelate offering 5 mg/kg/d for 28 days.…”

Section: Discussionmentioning

confidence: 99%

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Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial

Duque

Martı́nez

Vilchis-Gil

et al. 2014

Nutr J

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BackgroundIron deficiency is one of the most common nutritional deficiencies worldwide. It is more prevalent when iron requirements are increased during pregnancy and during growth spurts of infancy and adolescence. The last stage in the process of iron depletion is characterized by a decrease in hemoglobin concentration, resulting in iron deficiency anemia. Iron deficiency, even before it is clinically identified as anemia, compromises the immune response, physical capacity for work, and intellectual functions such as attention level. Therefore, interventions addressing iron deficiency should be based on prevention rather than on treatment of anemia. The aim of this study was to compare short- and medium-term effects on ferritin concentration of daily supplementation with ferrous sulfate or iron bis-glycinate chelate in schoolchildren with iron deficiency but without anemia.MethodsTwo hundred schoolchildren from public boarding schools in Mexico City who had low iron stores as assessed by serum ferritin concentration but without anemia were randomly assigned to a daily supplement of 30 mg/day of elemental iron as ferrous sulfate or iron bis-glycinate chelate for 12 weeks. Iron status was evaluated at baseline, one week post-supplementation (short term), and 6 months (medium term) after supplementation.ResultsFerritin concentration increased significantly between baseline and post-supplementation as well as between baseline and 6 months after supplementation. One week post-supplementation no difference was found in ferritin concentration between iron compounds, but 6 months after supplementation ferritin concentration was higher in the group that received bis-glycinate chelate iron. However, there is no difference in the odds for low iron storage between 6 months after supplementation versus the odds after supplementation; nor were these odds different by type of supplement. Hemoglobin concentration did not change significantly in either group after supplementation.ConclusionsSupplementing with 30 mg/d of elementary iron, either as ferrous sulfate or iron bis-glycinate chelate for 90 days, showed positive effects on increasing ferritin concentration in schoolchildren with low iron stores, and this effect persisted 6 months after supplementation.

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Section: Discussionmentioning

confidence: 99%

“…In various supplementation studies, correlations have been noted between the doses of iron given and/or the chemical formula used and side effects. The most common side effects associated with iron supplementation affect the gastrointestinal tract, manifesting as constipation, nausea, diarrhea, and vomiting [ 1 , 3 , 36 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial

Duque

Martı́nez

Vilchis-Gil

et al. 2014

Nutr J

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“…Uma orientação interessante é a preconizada por Silva et al 32 , que constataram que vitamina A parece contribuir para elevar o ferro orgânico da população, em especial em áreas onde coexistem a deficiência de vitamina A e a anemia. Outra orientação possível é o tratamento diário com ferro quelato glicinato, que segundo Ribeiro et al 33 é adequado para tratamento da anemia ferropriva na primeira infância, pela sua excelente tolerabilidade, contribuindo para o ganho de estatura entre crianças acima de 12 meses. Também, a instituição, desde 2005, do Programa Nacional de Suplementação de Ferro (PNSF), que consiste na suplementação profilática medicamentosa para crianças de 6 a 18 meses, é mais uma intervenção que espera proporcionar redução na prevalência de anemia das crianças atendidas em centros educacionais públicos.…”

Section: Tempo Que a Criança Frequentava A Crecheunclassified

Deficiência de ferro, prevalência de anemia e fatores associados em crianças de creches públicas do oeste do Paraná, Brasil

et al. 2011

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OBJETIVO: Avaliar o estado nutricional de ferro, a prevalência de anemia e fatores associados, em crianças de 6 a 24 meses frequentadoras de creche pública em Cascavel, Região Oeste do Paraná, Brasil. MÉTODOS: O estudo transversal foi realizado com amostra aleatória de 256 crianças. A coleta de dados (questionário, medidas antropométricas e amostras de sangue) ocorreu de julho a setembro de 2007. A deficiência de ferro foi avaliada em termos de transferrina, hemoglobina, volume corpuscular médio, ferro sérico e eosinófilos. Na análise estatística dos dados foram obtidas as odds ratio bruta e ajustada (regressão logística), bem como os respectivos níveis de significância (p-valor). Para identificar diferenças significativas entre as medidas quantitativas, adotou-se a Análise de Variância e o teste de comparação múltipla de Tukey. RESULTADOS: A prevalência da anemia foi de 29,7%, sendo que 77,3% das amostras apresentaram baixa concentração de ferro. A antropometria não apontou deficiência de macronutrientes, porém mostrou obesidade acima dos índices médios. Os fatores associados à anemia e à deficiência de ferro foram: doenças frequentes na família (OR=10,02), condições de moradia (OR=5,05), tempo de creche (OR=3,05), número de moradores na residência (OR=2,83) e falta de saneamento (OR=2,20). CONCLUSÃO: A prevalência de anemia e a elevada deficiência de ferro detectada evidenciam um grave problema de saúde pública entre os pré-escolares do município de Cascavel, Paraná. Apesar da amplitude do problema, a anemia não está sendo reconhecida, prevenida e tratada adequadamente. Neste estudo são sugeridas algumas possíveis intervenções.

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“…In that study, the effect on serum ferritin concentration was not checked. 20 Rojas and her colleague did their study on preschool children by giving milk fortified with ferrous sulphate to one group and milk fortified with ferrous bisglycinate to other groups. After 2 months they found a significant increase in serum ferritin in the ferrous bisglycinate group as compared to the ferrous sulphate group (p=0.022).…”

Section: Resultsmentioning

confidence: 99%

Comparison of Conventional and Newer Iron Preparations for the Treatment of Iron Deficiency Anaemia in Children

Perveen¹,

Raja²,

Khan

et al. 2020

JRMC

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Introduction: Commonly used iron salt, ferrous sulphate for the treatment of iron deficiency anemia, has several gastrointestinal side effects. Nowadays new iron salts such as ferrous bisglycinate are marketed with claims of raising hemoglobin faster with fewer gastrointestinal side effects. Objective: To compare the efficacy of ferrous sulphate with ferrous bisglycinate for the treatment of iron deficiency anemia in children. Methods: This randomized controlled trial was carried out at Children Hospital, PIMS, Islamabad from July 2015 to June 2016. A total of 136 children were selected through systematic sampling and randomized into 2 groups using a computer-generated table of random numbers; ferrous sulphate as group 1 and ferrous bisglycinate as group 2. Clinical outcome was assessed on the basis of a mean increase in hemoglobin after 12 weeks of therapy in both groups. The data was entered and analyzed using SPSS version 20. Results: The baseline characteristics i.e. mean age, mean hemoglobin levels were similar in both study groups. After 12 weeks of treatment, the mean increase in hemoglobin was 1.8 ±1.59 g/dl in ferrous sulphate group as compare to 2.5 ±1.31g/dl in ferrous bisglycinate group showing the higher level of rising with ferrous bisglycinate than ferrous sulphate, P =0.0033. Conclusion: Newer iron preparation, ferrous bisglycinate is a better treatment option than conventional preparation of ferrous sulphate for increasing hemoglobin in iron deficiency anemia in children.

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Tratamento da anemia ferropriva com ferro quelato glicinato e crescimento de crianças na primeira infância

Cited by 6 publications

References 20 publications

Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial

Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial

Deficiência de ferro, prevalência de anemia e fatores associados em crianças de creches públicas do oeste do Paraná, Brasil

Comparison of Conventional and Newer Iron Preparations for the Treatment of Iron Deficiency Anaemia in Children

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