Tratamiento con Duodopa: inconvenientes

González, Javier Mosquera

doi:10.33588/rn.50s01.2009699

Cited by 2 publications

(2 citation statements)

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“…Moreover, it provides analytical expressions which prove to be useful to make the link between the semiclassical Wigner treatment and the method of Goursaud et al [11]. The study of this link will be published elsewhere [46].…”

Section: Rotational Wigner Densitiesmentioning

confidence: 99%

New insights into the semiclassical Wigner treatment of photodissociation dynamics

Arbelo-González

Bonnet

Garcı́a-Vela

2013

Phys. Chem. Chem. Phys.

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The semiclassical Wigner treatment of Brown and Heller [J. Chem. Phys. 1981, 75, 186] is applied to direct triatomic (or triatomic-like polyatomic) photodissociations with the aim of accurately predicting final state distributions at relatively low computational cost, and having available a powerful interpretative tool. For the first time, the treatment takes rotational motions into account. The proposed formulation closely parallels the quantum description as far as possible. An approximate version is proposed, which is still accurate while numerically much more efficient. In addition to being weighted by usual vibrational Wigner distributions, final phase space states appear to be weighted by new rotational Wigner distributions. These densities have remarkable structures clearly showing that classical trajectories most contributing to rotational state j are those reaching the products with a rotational angular momentum close to [j(j + 1)](1/2) (in ℏ units). The previous methods involve running trajectories from the reagent molecule onto the products. The alternative backward approach [L. Bonnet, J. Chem. Phys., 2010, 133, 174108], in which trajectories are run in the reverse direction, is shown to strongly improve the numerical efficiency of the most rigorous method in addition to being state-selective, and thus, ideally suited to the description of state-correlated distributions measured in velocity imaging experiments. The results obtained by means of the previous methods are compared with rigorous quantum results in the case of Guo's triatomic-like model of methyl iodide photodissociation [J. Chem. Phys., 1992, 96, 6629] and close agreement is found. In comparison, the standard method of Goursaud et al. [J. Chem. Phys., 1976, 65, 5453] is only semi-quantitative.

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Section: Rotational Wigner Densitiesmentioning

confidence: 99%

New insights into the semiclassical Wigner treatment of photodissociation dynamics

Arbelo-González

Bonnet

Garcı́a-Vela

2013

Phys. Chem. Chem. Phys.

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“…La Duodopa presenta menos limitaciones en la indicación para pacientes con EP avanzados que las que existen habitualmente para la estimulación cerebral profunda. En cuanto a las complicaciones, cabe decir que son especialmente frecuentes aquéllas derivadas de la PEG y del dispositivo, lo cual ocasiona la necesidad de realizar exploraciones complementarias endoscópicas y radiológicas para corregir los problemas surgidos [34]. En un futuro, deberían mejorarse determina-dos aspectos técnicos que mejoren la tolerabilidad de la terapia, así como sopesarse la introducción de mejoras en el ámbito estético.…”

Section: Conclusionesunclassified

Infusión intraduodenal de levodopa

Valldeoriola

Cámara²

2010

RevNeurol

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In the advanced stages of Parkinson's disease (PD), the conventional orally-administered pharmacological treatment can prove to be insufficient to control the motor complications associated with the disease. One of the causes involved in the genesis of the motor fluctuations that are observed in PD is the variable absorption of the medication due to an irregular or erratic emptying of the gastric content. Today, a method of therapy is now available that allows levodopa to be administered directly into the duodenum at a continuous rate by a perfusor. The medication is applied through a duodenal catheter implanted by means of a percutaneous endoscopic gastrostomy. This new form of administration has been marketed under the name of Duodopa ®, which is a pharmaceutical form of levodopa in a micronised suspension in a thickening gel consisting of sodium carmelose. It is presented in combination with levodopa (20 mg/mL) and a dopa decarboxylase inhibitor, carbidopa (5 mg/mL). Duodopa has proved to be effective in reducing the percentage of off time and in diminishing the periods with disabling dyskinesias. This therapy has also proved to be useful for relieving certain non-motor aspects associated with PD and presents fewer limitations regarding indication for advanced PD patients than those that usually exist for the case of deep brain stimulation. Although the therapy has proved to be effective, it is not free of complications arising from malfunctioning of the infusion system or in relation to the percutaneous endoscopic gastrostomy.

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Tratamiento con Duodopa: inconvenientes

Cited by 2 publications

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New insights into the semiclassical Wigner treatment of photodissociation dynamics

New insights into the semiclassical Wigner treatment of photodissociation dynamics

Infusión intraduodenal de levodopa

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