2024
DOI: 10.1101/2024.05.14.594097
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TRBP regulates poly(I:C)-mediated apoptotic pathway by modulating miRNA biogenesis

Shota Azuma,
Yuko Nakano,
Tomoko Takahashi
et al.

Abstract: Interferon (IFN) response is usually triggered by the invasion of viral RNAs, and is known to suppress RNA silencing triggered by microRNAs (miRNAs). However, the detailed mechanism regulating RNA silencing during IFN response has not been elucidated. We previously reported that a virus sensor protein, LGP2, which is an upregulated protein during IFN response, interacts with an RNA-binding protein, TRBP. Since TRBP is an RNA-binding protein which enhances miRNA biogenesis in collaboration with Dicer, the inter… Show more

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