Treadmill Exercise Improved Memory Evocation and Upregulated Alpha7 Nicotinic Receptors Density in Lower Cognitive Performance Rats

Albuquerque, Marilia Silva; Baraldi-Tornisielo, Ticiana; Rotulo, Carolina Cardoso; Caetano, Ariadiny Lima; Azevedo-Martins, Anna Karenina; Buck, Hudson Sousa; Viel, Tânia Araújo

doi:10.4172/2469-9780.1000108

Cited by 2 publications

(2 citation statements)

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“…Moderate-intensity exercise groups displayed a consistent pattern of increased protein expression, suggesting that despite nicotine exposure or multiple behavioral test, it seems likely that mild forced exercise induces these molecular changes in the brain. Our data are consistent with previous studies that moderate intensity treadmill exercise improved memory evocation and upregulated α7 nAChRs density in lower cognitive performance rats (Albuquerque, Baraldi-Tornisielo, Rotulo, Caetano, & Martins, 2015). It is well known that moderate-intensity exercise improves cognition via Akt, CREB, and BDNF signaling in aging rats (Aguiar et al, 2011).…”

Section: Exercise and α7 Nachr-mediated Signal Transduction In Prefrontal Cortexsupporting

confidence: 93%

Exercise improves nicotine reward‐associated cognitive behaviors and related α7 nAChR‐mediated signal transduction in adolescent rats

Zhou

et al. 2018

Journal Cellular Physiology

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The adolescent brain is vulnerable to long-lasting cognitive disturbances resulting from nicotine exposure. Although exercise has been used as an intervention for ameliorating cognitive deficits in various disorders, the effect on cognitive changes induced by nicotine exposure and its underlying mechanisms remain unclear. The purpose of this study was to investigate the effects of exercise on nicotine reward-associated cognitive behaviors in adolescent rats subjected to nicotine conditioned place preference paradigm (CPP). Male adolescent rats were trained on the Go/NoGo task, then subjected to nicotine CPP, and then randomly separated into four groups: sedentary (SED), high- (HE), moderate- (ME), and low-intensity (LE) exercise. Rats in exercise groups performed treadmill running 30 min daily for 10 days. Results showed that MEs had shorter escape latencies in the Morris water maze (MWM) test compared to SEDs. Although time spent and distance swam in the target quadrant significantly increased in both the MEs and HEs, the number of target quadrant crosses increased significantly only in MEs. MEs and HEs showed higher performance accuracy on NoGo and lower scores on CPP tasks. Expression of α7 nicotinic acetylcholine receptors (nAChRs) and downstream signaling molecules increased in MEs in prefrontal cortex but not hippocampus, with α7 nAChRs expression positively associated with NoGo accuracy and MWM probe test performance, but negatively correlated with CPP scores. The findings of this study suggest that moderate-intensity exercise can improve nicotine induced cognitive behaviors, and implicates prefrontal cortical α7 nAChR-mediated signal transduction as a possible mechanism.

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Section: Exercise and α7 Nachr-mediated Signal Transduction In Prefrontal Cortexsupporting

confidence: 93%

Exercise improves nicotine reward‐associated cognitive behaviors and related α7 nAChR‐mediated signal transduction in adolescent rats

Zhou

et al. 2018

Journal Cellular Physiology

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show abstract

“…Results from this study reinforce the importance of the moderate exercise to those who present learning and memory difficulties [2].…”

Section: Editor's Notesupporting

confidence: 59%

Novel Drugs for Neurodisorders

Mohan¹

2016

Neurochem Neuropharm

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Treadmill Exercise Improved Memory Evocation and Upregulated Alpha7 Nicotinic Receptors Density in Lower Cognitive Performance Rats

Cited by 2 publications

References 0 publications

Exercise improves nicotine reward‐associated cognitive behaviors and related α7 nAChR‐mediated signal transduction in adolescent rats

Exercise improves nicotine reward‐associated cognitive behaviors and related α7 nAChR‐mediated signal transduction in adolescent rats

Novel Drugs for Neurodisorders

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