Treatable traits and their application in high‐, middle‐ and low‐income countries

Moving towards a Treatable Traits model of care for the management of obstructive airways diseases

“…Logistical barriers such as geography, culture, finance, and healthcare resources may affect the provision of care in chronic airways diseases, especially for some targeted or multidisciplinary interventions [7,9,11,14,66]. Implementation strategies need to recognize these barriers and adapt to the resources available, including ensuring access to appropriate investigations and training in how to respond appropriately to findings [66]. However, although additional resources may be required to meet these needs in some situations, a TT-based strategy can help to not 'waste' drugs on the wrong patients [66].…”

“…Implementation strategies need to recognize these barriers and adapt to the resources available, including ensuring access to appropriate investigations and training in how to respond appropriately to findings [66]. However, although additional resources may be required to meet these needs in some situations, a TT-based strategy can help to not 'waste' drugs on the wrong patients [66]. Expected outcomes are the reduction of unnecessary costs and risk of overtreatment [66] as well as medication and hospitalization/healthcare use, which are the major direct costs of airways diseases [3,51,67], so the approach may prove cost effective for the system as a whole.…”

Contemporary Concise Review 2019: Chronic obstructive pulmonary disease

“…With novel molecular techniques, the biology of these implicated genes will be elucidated in the near future, which will lead to new therapeutic approaches for patients with COPD. Until then, McDonald and Gibson have advocated a treatable traits approach for the therapeutic management of COPD patients . This approach marries clinical traits (e.g.…”

“…Until then, McDonald and Gibson have advocated a treatable traits approach for the therapeutic management of COPD patients. 35 This approach marries clinical traits (e.g. airflow limitation) with treatments that target these traits (e.g.…”

Yes, there really are individuals with severe asthma: the importance and limitations of data obtained from specialized centers

“…4 Those elements are usually associated with the inappropriate use of medications and should be included in the diagnostic protocol for and assessment of severe asthma. 5 …”