Treating Arterial Ageing in Patients with Diabetes: From Mechanisms to Effective Drugs

Lunder, Mojca; Janić, Miodrag; Šabovič, Mišo

doi:10.3390/ijms22062796

Cited by 14 publications

(14 citation statements)

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“…Сообщается о положительном влиянии данного класса препаратов как на уровень АД, так и на показатели АЖ [18]. При приеме иАПФ у больных СД отмечалось увеличение активности брадикинина, снижение оксидативного стресса, повышение биодоступности оксида азота, снижение отложения коллагена в стенке сосуда [19].…”

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Analysis of factors associated with arterial stiffness in the general working-age population

2022

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Aim. To examine associations of cardio-ankle vascular index (CAVI) with classical, behavioral and social risk factors (RFs) of cardiovascular disease (CVD) in adult population.Material and methods. The study included 1365 people (women, 59%) from a representative sample aged 25-64 years (ESSE-RF), who underwent standard cardiology screening and volume sphygmography (VaSera-1500). All respondents signed an informed consent to participate in the study. The analysis included blocks of classical, social and behavioral risk factors for CVD. A linear model was used to identify associations. An error rate of <5% was considered significant.Results. Age, sex, systolic blood pressure (SBP), triglycerides were associated with higher CAVI values, and body mass index (BMI) was associated with lower values, respectively. After 45 years, a direct association with heart rate (HR) became increasingly important, while after 50 years — with diabetes and the intake of beta-blockers, while the association between diabetes and CAVI was observed only among individuals not taking angiotensin-converting enzyme (ACE) inhibitors. A direct association was found with high-sensitivity C-reactive protein (hsCRP) in men, and an inverse association with diuretics in women, respectively. A sedentary work in combination with a history of bronchitis or with positive family history for CVD showed a direct relationship, while a sufficient physical activity (PA) showed an inverse relationship with the studied indicator, but only among people with belowaverage income.Conclusion. According to the data obtained, in addition to age and sex, the following risk factors made a significant contribution to CAVI parameters in the examined population: BMI, SBP, triglycerides, diabetes, HR, intake of betablockers, diuretics, ACE inhibitors; hsCRP, PA. The unfavorable role of betablockers, high HR, diabetes, sedentary work, chronic lung pathology, hereditary burden, as well as the protective role of ACE inhibitors, diuretics and intense PA in relation to arterial stiffness in the working-age population has been shown. Additional studies are needed to determine the nature of a number of associations. The results obtained may contribute to the study of CAVI role in risk stratification and further development of methodological approaches to CVD prevention.

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Analysis of factors associated with arterial stiffness in the general working-age population

2022

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“…Moreover, within the limit of the cross-sectional design of the analyses, we found that the presence of MAFLD potentiated the agerelated eGFR decline in every group which may be a result of the accelerated vessel ageing induced by the MAFLD-related metabolic disorders, consistent with data for diabetes-associated accelerated arterial ageing. 43 Independent of the involved mechanisms, MAFLD-associated glomerular hyperfiltration per se may be a major pathogenic factor for GFR decline and CKD progression. 9 Thus, mitigation of MAFLD and its risk factors, could be instrumental in ameliorating glomerular hyperfiltration and limiting MAFLD-associated accelerated GFR decline.…”

Section: Age-declining Egfr In Subjects With and Without Mafld Accord...mentioning

confidence: 99%

MAFLD and glomerular hyperfiltration in subjects with normoglycemia, prediabetes and type 2 diabetes: A cross‐sectional population study

Abbate,

Parvanova,

López‐González

et al. 2024

Diabetes Metabolism Res

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BackgroundMetabolic dysfunction‐associated fatty liver disease (MAFLD, 2020 diagnostic criteria) and glomerular hyperfiltration share common risk factors, including obesity, insulin resistance, impaired glucose tolerance, diabetes, dyslipidemia, and hypertension.AimsTo assess the prevalence of MAFLD and its association with glomerular hyperfiltration and age‐related worsening of kidney function in subjects with normoglycemia, prediabetes and type 2 diabetes mellitus (T2DM).MethodsWe analysed data recorded during occupational health visits of 125,070 Spanish civil servants aged 18–65 years with a de‐indexed glomerular filtration rate (GFR) estimated with the chronic‐kidney‐disease‐epidemiological (CKD‐EPI) equation (estimated glomerular filtration rate [eGFR]) ≥60 mL/min. Subjects were categorised according to fasting plasma glucose levels <100 mg/dL (normoglycemia), ≥100 and ≤ 125 mg/dL (prediabetes), or ≥126 mg/dL and/or antidiabetic treatment (T2DM). The association between MAFLD and glomerular hyperfiltration, defined as a de‐indexed eGFR above the age‐ and gender‐specific 95th percentile, was assessed by multivariable logistic regression.ResultsIn the whole study group, MAFLD prevalence averaged 19.3%. The prevalence progressively increased from 14.7% to 33.2% and to 48.9% in subjects with normoglycemia, prediabetes and T2DM, respectively (p < 0.001 for trend). Adjusted odds ratio (95% CI) for the association between MAFLD and hyperfiltration was 9.06 (8.53–9.62) in the study group considered as a whole, and 8.60 (8.03–9.21), 9.52 (8.11–11.18) and 8.31 (6.70–10.30) in subjects with normoglycemia, prediabetes and T2DM considered separately. In stratified analyses, MAFLD amplified age‐dependent eGFR decline in all groups (p < 0.001).ConclusionsMAFLD prevalence increases across the glycaemic spectrum. MAFLD is significantly associated with hyperfiltration and amplifies the age‐related eGFR decline.

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“…Endothelial dysfunction represents one of the earliest vascular complications in patients with diabetes and gradually leads to increased arterial stiffness 8 . Arterial elasticity generally deteriorates with age in the general population, and this effect is further amplified in patients with diabetes 9 . We hypothesized that vascular aging may be a risk factor for increased AoD; although the precise relationship between baPWV and AoD in patients with diabetes remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…8 Arterial elasticity generally deteriorates with age in the general population, and this effect is further amplified in patients with diabetes. 9 We hypothesized that vascular aging may be a risk factor for increased AoD; although the precise relationship between baPWV and AoD in patients with diabetes remains unclear.…”

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The positive correlation between brachial‐ankle pulse wave velocity and aortic diameter in Chinese patients with diabetes

Xie

et al. 2022

J of Clinical Hypertension

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Aortic dilation is associated with an increased risk of cardiovascular diseases.Increased brachial-ankle pulse wave velocity (baPWV) is a hallmark of vascular aging and arterial stiffness, as well as an important risk factor for vascular disease. This study aimed to retrospectively analyze the correlation between baPWV and aortic diameter (AoD) of inpatients with diabetes. A total of 1294 diabetic patients with the detailed medical records were investigated. Arterial stiffness was assessed using baPWV and AoD using echocardiography. The results showed that baPWV and AoD increase with age (p <0.05). Based on multiple linear regression analysis, age, systolic and diastolic blood pressure, left atrial diameter, right ventricle diameter, pulmonary artery diameter, peak velocity of early transmitral blood flow/peak velocity of late transmitral blood flow, and baPWV independently correlated with AoD in patients with diabetes. Additionally, an increased risk of aortic dilation occurred in the highest baPWV quartile compared with the lowest quartile (p <0.001). In conclusion, baPWV is independently and positively associated with AoD. Hence, prospective cohorts or randomized clinical trials will be the next step to further determine whether interventions designed to improve arterial stiffness in patients with diabetes will reduce the risk of aortic dilation. K E Y W O R D Saortic diameter, arterial stiffness, brachial-ankle pulse wave velocity, diabetes BACKGROUNDCardiovascular disease is a leading cause of mortality and a threat to human health worldwide. Several studies have reported that a larger aortic diameter (AoD) is prospectively associated with cardiovascular morbidity, 1,2 and has been described as an important marker of hypertension-related organ damage. 3 Moreover, excessive dilation of the aorta was linked to aneurysm formation and dissection, both of which are potentially fatal diseases. 4 To date, however, few proven therapeutic strategies are available to alleviate or reverse this progression. Thus, the study of risk factors related to aortic dilation mayThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Treating Arterial Ageing in Patients with Diabetes: From Mechanisms to Effective Drugs

Cited by 14 publications

References 115 publications

Analysis of factors associated with arterial stiffness in the general working-age population

Analysis of factors associated with arterial stiffness in the general working-age population

MAFLD and glomerular hyperfiltration in subjects with normoglycemia, prediabetes and type 2 diabetes: A cross‐sectional population study

The positive correlation between brachial‐ankle pulse wave velocity and aortic diameter in Chinese patients with diabetes

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