Treating cancer through modulating exosomal protein loading and function: The prospects of natural products and traditional Chinese medicine

Meng, Lulu; Zhang, Chao; Yu, Pei

doi:10.1016/j.phrs.2024.107179

Pharmacological Research

2024

DOI: 10.1016/j.phrs.2024.107179

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Treating cancer through modulating exosomal protein loading and function: The prospects of natural products and traditional Chinese medicine

Lulu Meng,

Chao Zhang,

Pei Yu

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Cited by 5 publications

References 156 publications

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Mechanistic study of quercetin in the treatment of hepatocellular carcinoma with diabetes via MEK/ERK pathway

Lin,

Zhou,

Yuan

et al. 2024

International Immunopharmacology

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Mechanistic study of quercetin in the treatment of hepatocellular carcinoma with diabetes via MEK/ERK pathway

Lin,

Zhou,

Yuan

et al. 2024

International Immunopharmacology

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Nrf2 mediated signaling axis in heart failure: Potential pharmacological receptor

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Liu

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Exosomal ncRNAs in reproductive cancers

Kowalczyk,

Wrzecińska,

Gałęska

et al. 2024

Biology of Reproduction

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Extracellular vesicles, particularly exosomes, play a pivotal role in the cellular mechanisms underlying cancer. This review explores the various functions of exosomes in the progression, growth, and metastasis of cancers affecting the male and female reproductive systems. Exosomes are identified as key mediators in intercellular communication, capable of transferring bioactive molecules such as miRNAs, proteins, and other nucleic acids that influence cancer cell behavior and tumor microenvironment interactions. It has been shown that nc-RNAs transported by exosomes play an important role in tumor growth processes. Significant molecules that may serve as biomarkers in the development and progression of male reproductive cancers include miR-125a-5p, miR-21, miR-375, the miR-371 ~ 373 cluster, and miR-145-5p. For female reproductive cancers, significant miRNAs include miR-26a-5p, miR-148b, miR-205, and miRNA-423-3p. This review highlights the potential of these ncRNAs as biomarkers and prognostics in tumor diagnostics. Understanding the diverse roles of exosomes may hold promise for developing new therapeutic strategies and improving treatment outcomes for cancer patients.

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Treating cancer through modulating exosomal protein loading and function: The prospects of natural products and traditional Chinese medicine

Cited by 5 publications

References 156 publications

Mechanistic study of quercetin in the treatment of hepatocellular carcinoma with diabetes via MEK/ERK pathway

Mechanistic study of quercetin in the treatment of hepatocellular carcinoma with diabetes via MEK/ERK pathway

Nrf2 mediated signaling axis in heart failure: Potential pharmacological receptor

Exosomal ncRNAs in reproductive cancers

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