Treating Iodine Deficiency: Long-Term Effects of Iodine Repletion on Growth and Pubertal Development in School-Age Children

Markou, Kostas B.; Tsekouras, Athanasios; Anastasiou, Eleni; Vlassopoulou, Barbara; Koukkou, Eftychia; Vagenakis, George A.; Mylonas, Panagiotis; Vasilopoulos, Charalampos; Theodoropoulou, Anastasia; Rottstein, Loredana; Lampropoulou, Evgenia; Apostolopoulos, Dimitris; Jabarov, Rauf; Vagenakis, Apostolos G.; Georgopoulos, Neoklis A.

doi:10.1089/thy.2007.0277

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Data on the effect of iodine supplementation show no effect of this micronutrient on linear growth [77]. By evaluating a cohort of approximately 300 children followed up to 4 years after the assumption of iodized oil, an improvement of linear growth was observed [89].…”

Section: Micronutrientsmentioning

confidence: 99%

The Effects of Nutrition on Linear Growth

et al. 2022

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Linear growth is a complex process and is considered one of the best indicators of children’s well-being and health. Genetics, epigenetics and environment (mainly stress and availability of nutrients) are the main regulators of growth. Nutrition exerts its effects on growth throughout the course of life with different, not completely understood mechanisms. Cells have a sophisticated sensing system, which allows growth processes to occur in the presence of an adequate nutrient availability. Most of the nutritional influence on growth is mediated by hormonal signals, in turn sensitive to nutritional cues. Both macro- and micro-nutrients are required for normal growth, as demonstrated by the impairment of growth occurring when their intake is insufficient. Clinical conditions characterized by abnormal nutritional status, including obesity and eating disorders, are associated with alterations of growth pattern, confirming the tight link between growth and nutrition. The precise molecular mechanisms connecting nutrition to linear growth are far from being fully understood and further studies are required. A better understanding of the interplay between nutrients and the endocrine system will allow one to develop more appropriate and effective nutritional interventions for optimizing child growth.

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Section: Micronutrientsmentioning

confidence: 99%

The Effects of Nutrition on Linear Growth

et al. 2022

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“…Перед обследованием родители были информированы о целях и задачах проводимого исследования и дали согласие на участие в нем подростков. Степень йодного дефицита оценивали по критериям Всемирной организации здравоохранения: ренальная йодурия <20 мкг / л -тяжелый йододефицит; 20-49 мкг / л -умеренный; 50-99 мкг / л -легкий [17]. Изучали антропометрические параметры: рост (м), массу тела (кг), индекс массы тела (ИМТ).…”

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Peculiarities of physical and sexual development of boys in the onset of puberty in different ecologo-geographical regions of the Republic of Dagestan

Камалов

Газимагомедов

Magomedova

2018

Androl. genit. hir.

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The study objectiveis to compare the characteristics of physical and sexual development of boys aged 11–13 years living in different ecological and geographical areas of the Republic of Dagestan and to determine the effect of chronic iodine deficiency on the onset of puberty.Materials and methods. In a lowland area containing 11 districts, 501 subjects were examined; in a mountain area containing 17 districts, 325 subjects were examined; in a submontane area containing 7 districts, 274 subjects were examined. In total, 1100 boys aged 11–13 years were randomly selected.Results.Physical development of the boys was mostly characterized as normal but with a clear tendency toward lower values, especially in the submontane districts. In boys living in the areas with severe iodine deficiency, delayed onset of puberty was observed 3.2 times more frequently than in their counterparts living in the districts with mild iodine deficiency. Total fraction of boys with signs of delayed sexual development was 38.5 %, and they mostly lived in the submontane area.Conclusion.Emerging in Russia tendency toward lowered characteristics of physical development of boys is observed in the Republic of Dagestan. This confirms the negative effect of chronic iodine deficiency on sexual development of boys which manifests through delayed sexual maturity.

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Extrapolation of Hypothalamic-Pituitary-Thyroid Axis Perturbations and Associated Toxicity in Rodents to Humans: Case Study with Perchlorate

Fisher

Lumen

Latendresse

et al. 2012

Journal of Environmental Science and Health, Part C

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Functional aspects of the Hypothalamic-Pituitary-Thyroid (HPT) axis in rats and humans are compared, exposing why extrapolation of toxicant-induced perturbations in the rat HPT axis to the human HPT axis cannot be accomplished using default risk assessment methodology. Computational tools, such as biologically based dose response models for the HPT axis, are recommended to perform complex animal to human extrapolations involving the HPT axis. Experimental and computational evidence are presented that suggest perchlorate acts directly on the thyroid gland in rats. The apparent escape from perchlorate-induced inhibition of thyroidal uptake of radioactive iodide in humans is discussed along with "rebound" or increased thyroidal uptake of radioactive iodide observed after discontinued clinical treatment with perchlorate.

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Treating Iodine Deficiency: Long-Term Effects of Iodine Repletion on Growth and Pubertal Development in School-Age Children

Abstract: Our results demonstrate that long-term correction of severe ID leads to sustained improvement of linear growth accompanied by a normalization of the time of onset of pubertal development for both sexes.

Cited by 7 publications

References 20 publications

The Effects of Nutrition on Linear Growth

The Effects of Nutrition on Linear Growth

Peculiarities of physical and sexual development of boys in the onset of puberty in different ecologo-geographical regions of the Republic of Dagestan

Extrapolation of Hypothalamic-Pituitary-Thyroid Axis Perturbations and Associated Toxicity in Rodents to Humans: Case Study with Perchlorate

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