Treatment delay and facility case volume are associated with survival in early‐stage glottic cancer

Cheraghlou, Shayan; Kuo, Phoebe; Judson, Benjamin L.

doi:10.1002/lary.26259

Cited by 58 publications

(88 citation statements)

References 41 publications

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“…Six studies (46%) 10,33,36–39 included all head and neck subsites, while 7 studies (54%) were subsite specific (5 oral cavity, 1 oropharynx, and 1 larynx). 19,22,30–32,34,35 Four of the studies (31%) 22,31,33,36 did not define the rationale or methods for their definition of prolonged DTI, 4 (31%) 19,35,37,38 used calendar-based categorical definitions (eg, <30 days, 31–60 days), 3 (23%) 30,34,39 used cohort-based quartiles or medians, and 2 (15%) 10,32 used recursive partition analysis to determine an optimal DTI threshold. One study, which exclusively examined cancer of the oral cavity, suggested that DTI of less than 20 days was optimal.…”

Section: Resultsmentioning

confidence: 99%

“…10 An association between delays in DTI and poorer oncologic outcomes was observed in 9 studies (69%). 10,22,31–37 The delayed DTI threshold varied from more than 20 days to 120 days or more. The 4 studies that did not find an association between DTI and survival analyzed thresholds of 50 days or more (vs 24days or less), 45 days or more (vs 30 days or less), and more than 30 days (vs 30 days or less; analyzed in 2 studies).…”

Section: Resultsmentioning

confidence: 99%

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Association of Treatment Delays With Survival for Patients With Head and Neck Cancer

Graboyes

Kompelli

Neskey

et al. 2019

JAMA Otolaryngol Head Neck Surg

223

313

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IMPORTANCE Delays in the delivery of care for head and neck cancer (HNC) are a key driver of poor oncologic outcomes and thus represent an important therapeutic target. OBJECTIVE To synthesize information about the association between delays in the delivery of care for HNC and oncologic outcomes. EVIDENCE REVIEW A systematic review of the English-language literature in PubMed/MEDLINE and Scopus published between January 1, 2007, and February 28, 2018, was performed to identify articles addressing the association between treatment delays and oncologic outcomes for patients with HNC. Articles that were included (1) addressed cancer of the oral cavity, oropharynx, hypopharynx, or larynx; (2) discussed patients treated in 2004 or later; (3) analyzed time of diagnosis to treatment initiation (DTI), time from surgery to the initiation of postoperative radiotherapy, and/or treatment package time (TPT; the time from surgery through the completion of postoperative radiotherapy); (4) included a clear definition of treatment delay; and (5) analyzed the association between the treatment time interval and an oncologic outcome measure. Quality assessment was performed using the Institute of Health Economics Quality Appraisal Checklist for Case Series Studies. FINDINGS A total of 18 studies met inclusion criteria and formed the basis of the systematic review. Nine studies used the National Cancer Database and 6 studies were single-institution retrospective reviews. Of the 13 studies assessing DTI, 9 found an association between longer DTI and poorer overall survival; proposed DTI delay thresholds ranged from more than 20 days to 120 days or more. Four of the 5 studies assessing time from surgery to the initiation of postoperative radiotherapy (and all 4 studies assessing guideline-adherent time to postoperative radiotherapy) found an association between a timely progression from surgery to the initiation of postoperative radiotherapy and improved overall or recurrence-free survival. Of the 5 studies examining TPT, 4 found that prolonged TPT correlated with poorer overall survival; proposed thresholds for prolonged TPT ranged from 77 days or more to more than 100 days. CONCLUSIONS AND RELEVANCE Timely care regarding initiation of treatment, postoperative radiotherapy, and TPT is associated with survival for patients with HNC, although significant heterogeneity exists for defining delayed DTI and TPT. Further research is required to standardize optimal time goals, identify barriers to timely care for each interval, and design interventions to minimize delays.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association of Treatment Delays With Survival for Patients With Head and Neck Cancer

Graboyes

Kompelli

Neskey

et al. 2019

JAMA Otolaryngol Head Neck Surg

223

313

View full text Add to dashboard Cite

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“…The NCDB is a nationwide clinical surveillance resource data set that includes approximately 70% of all newly diagnosed malignancies in the United States from over 1,500 cancer programs, as previously described . The NCDB has been used in a number of studies to study treatment‐related outcomes in head and neck malignancies . This study was determined to be exempt from institutional review by the Yale Human Investigation Committee.…”

Section: Methodsmentioning

confidence: 99%

HPV status in unknown primary head and neck cancer: Prognosis and treatment outcomes

et al. 2018

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“…Studies in small, single‐institution cohorts have suggested that delays may adversely affect survival. However, this has not been shown in a national cohort and no national benchmarks exist …”

Section: Introductionmentioning

confidence: 92%

“…Other delays, such as delays between diagnosis and treatment initiation and between surgery and adjuvant treatment, have been associated with survival in some studies. However, the literature is inconclusive …”

Section: Introductionmentioning

confidence: 99%

Treatment delays in laryngeal squamous cell carcinoma: A national cancer database analysis

et al. 2018

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Treatment delay and facility case volume are associated with survival in early‐stage glottic cancer

Abstract: 4. Laryngoscope, 127:616-622, 2017.

Cited by 58 publications

References 41 publications

Association of Treatment Delays With Survival for Patients With Head and Neck Cancer

Association of Treatment Delays With Survival for Patients With Head and Neck Cancer

HPV status in unknown primary head and neck cancer: Prognosis and treatment outcomes

Treatment delays in laryngeal squamous cell carcinoma: A national cancer database analysis

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