Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study

Shellhaas, Renée A.; Chang, Taeun; Wusthoff, Courtney J.; Soul, Janet S.; Massey, Shavonne L.; Chu, Catherine J.; Cilio, Maria Roberta; Bonifacio, Sonia L.; Abend, Nicholas S.; Tsuchida, Tammy N.; Glass, Hannah C.

doi:10.1016/j.jpeds.2016.10.039

Cited by 62 publications

(58 citation statements)

References 15 publications

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“…Neonates from the initial NSR cohort were previously reported. 2,3,5 Neonates were included if they received a loading dose of an ASM and adequate documentation regarding response to the loading dose was available. Neonates with events that were determined not to be seizures based on history, semiology, or cEEG were not enrolled.…”

Section: Methodsmentioning

confidence: 99%

“…1 Little is known about additional characteristics associated with initial treatment failure, although we previously showed that preterm and term neonates were equally likely to have persistent seizures after a loading dose of phenobarbital 2 and there was no difference in treatment response to initial doses of phenobarbital, phenytoin, or levetiracetam as the first-line ASM. 3 We hypothesized that treatment response to ASMs would not differ by seizure etiology and that treatment response would be dose dependent. Confirming these hypotheses provides important evidence for clinical care and data to inform future clinical trial design.…”

Section: Introductionmentioning

confidence: 99%

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Response to antiseizure medications in neonates with acute symptomatic seizures

et al. 2019

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Summary In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic‐ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Future trial design may test ASMs in neonates with all acute symptomatic seizure etiologies and could target neonates with seizures refractory to an initial ASM.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Response to antiseizure medications in neonates with acute symptomatic seizures

et al. 2019

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“…Table II compares the effect of WP bases selection on the classification accuracy (CA) for ABCD vs E classification based on a 2-fold cross validation. The results showed that the WP coefficients (5,1), (4,1), (4,2) performed better than the other WP basis candidates. Therefore; the WP coefficients (5,1), (4,1), (4,2) were fixed as the best WP bases for all other analyses in this work.…”

Section: Discussionmentioning

confidence: 97%

A new method for epileptic seizure classification in EEG using adapted wavelet packets

Ahmadi

Shalchyan

Daliri

2017

2017 Electric Electronics, Computer Science, Biomedical Engineerings' Meeting (EBBT)

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Electroencephalography (EEG), as the most common tool for epileptic seizure classification, contains useful information about different physiological states of the brain. Seizure related features in EEG signals can be better identified when localized in time-frequency basis projections. In this work, a novel method for epileptic seizure classification based on wavelet packets (WPs) is presented in which both mother wavelet function and WP bases are adapted a posteriori to improve the seizure classification. A support vector machine (SVM) as classifier is used for seizure versus non-seizure EEG segment classification. In order to evaluate the proposed algorithm, a publicly available dataset containing different groups' patient with epilepsy and healthy individuals are used. The obtained results indicate that the proposed method outperforms some previously proposed algorithms in epileptic seizure classification.

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“…This is arguable since children with DCD might also display persistent difficulties in the acquisition of a variety of other basic gross and fine motor skills (recommendation 2) 3 whereas gross motor skills (recommendation 19, statement 3) 3 are of particular interest in terms of a primary source of environmental stress. 4 Thus, it seems not only questionable whether the selection of tasks within the ALSPAC coordination test facilitates an identification of the entire range of the intended target group (individuals with DCD) but more specifically, whether the partial representation of the problem displayed here is suitable for the elaboration of the environmental context.…”

mentioning

confidence: 96%

“…Hypothermia may never be proven (though stroke cases within the cooling trials have been studied), but euthermia with antipyretics and antibiotics for fever are prudent. These fundamentals are likely to be applicable to the other neonatal stroke syndromes which are increasingly described, but also suffer from the same paucity of evidence.…”

mentioning

confidence: 99%