2020
DOI: 10.1136/bcr-2019-232299
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Treatment failure after multiple courses of triclabendazole in a Portuguese patient with fascioliasis

Abstract: Fascioliasis is a trematode flatworm infection caused by Fasciola hepatica. Humans are incidental hosts, and the infection is most often acquired by eating watercress grown in contaminated water in livestock-rearing areas. Triclabendazole is the only highly effective treatment, with a reported cure rate of >90%. Treatment failure may be due to several factors, though resistance is rare in humans and scarcely reported, most probably a reflection of the widespread use of anthelmintics in livestock. There are … Show more

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Cited by 11 publications
(7 citation statements)
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“… 87 Importantly, triclabendazole resistance in human with fascioliasis is also emerging and is likely associated with resistance in livestock. Case series from Chile, 91 The Netherlands, 92 Peru, 83 Portugal, 93 and Turkey 94 have documented treatment failures despite multiple doses of triclabendazole. Our group documented treatment failures after multiple courses of treatment in 7/19 (37%) patients referred to our center for treatment.…”
Section: Treatment and Controlmentioning
confidence: 99%
“… 87 Importantly, triclabendazole resistance in human with fascioliasis is also emerging and is likely associated with resistance in livestock. Case series from Chile, 91 The Netherlands, 92 Peru, 83 Portugal, 93 and Turkey 94 have documented treatment failures despite multiple doses of triclabendazole. Our group documented treatment failures after multiple courses of treatment in 7/19 (37%) patients referred to our center for treatment.…”
Section: Treatment and Controlmentioning
confidence: 99%
“…The absence of a liver fluke vaccine and increasing anthelmintic resistance threaten the sustainability of liver fluke control. Triclabendazole treatment failure is widely reported for livestock and more recent cases of emerging resistance in human populations is deeply concerning and highlights the pressing need for new flukicides, particularly targeting the highly pathogenic early-stage juveniles [4,[12][13][14].…”
Section: Introductionmentioning
confidence: 99%
“…Cabada, et al, comunicaron resistencia al triclabendazol en dosis repetidas en 7 de 19 casos en Cusco, Perú 28 . En fecha reciente se ha informado resistencia al triclabendazol luego de varios ciclos de tratamiento en un paciente portugués 29 . En otro trabajo peruano, Terashima, et al, indicaron que el tratamiento con triclabendazol en dosis única (10 mg/kg) no fue suficiente para cumplir con el criterio de cura parasitológica en 11 de 12 casos de fasciolasis humana 30 .…”
Section: Aguda O Invasivaunclassified