Treatment methods toward improving the anti-infection ability of poly(etheretherketone) implants for medical applications

Zhang, Shuqi; Long, Jiazhen; Chen, Lin; Zhang, Jie; Fan, Yunjian; Shi, Jiayu; Huang, Yuanjin

doi:10.1016/j.colsurfb.2022.112769

Cited by 14 publications

(12 citation statements)

References 148 publications

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“…The surface morphology and composition play an important role in the osseointegration of biomaterials due to the ability to mediate protein adsorption and cell function . Numerous studies have shown that a 3D porous network can be formed on the PEEK surface by sulfonation.…”

Section: Discussionmentioning

confidence: 99%

“…The surface morphology and composition play an important role in the osseointegration of biomaterials due to the ability to mediate protein adsorption and cell function. 30 Numerous studies have shown that a 3D porous network can be formed on the PEEK surface by sulfonation. The 3D porous network not only has good osseointegration, cytocompatibility, and antibacterial properties but also can be used for the loading of biological factors and drugs.…”

Section: Discussionmentioning

confidence: 99%

“…Another group was designed to investigate the performance of sulfonated PEEK using different concentrations of H 2 SO 4 as the coagulants for the same sulfonation time. Specifically, the PEEK disks were immersed in concentrated H 2 SO 4 (95−98 wt %) at room temperature for 3 min and then coagulated with 5,10,15,20,30,35,40,45, and 50% v/v H 2 SO 4 for 1 h, respectively. These samples were denoted as SPS-n%, where n represents the concentration of H 2 SO 4 .…”

Section: Sample Preparationmentioning

confidence: 99%

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The Formation Process and Mechanism of the 3D Porous Network on the Sulfonated PEEK Surface

Xie,

Xiao,

Song

et al. 2024

ACS Appl. Mater. Interfaces

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A three-dimensional (3D) porous network can be prepared on the PEEK surface by sulfonation with enhanced osseointegration and antibacterial properties. However, few studies have been conducted on the formation mechanism of a 3D porous network. In this work, the surface and cross-sectional morphologies, chemical compositions, functional groups, surface wettability, and crystalline states of sulfonated PEEK were investigated at different sulfonation times and coagulant concentrations. The results show that the number of nodular structures and broken fibers on the sulfonated PEEK surface as well as the size of macrovoids in the cross sections increase with increasing sulfonation times when water is used as a coagulant. In contrast, dilute sulfuric acid as a coagulant can inhibit the formation of surface porous structures and macrovoids in the cross sections. Moreover, all of the sulfonated PEEK samples have the same chemical compositions but exhibit better hydrophilicity as the number of microsized pores decreases. It is proposed that non-solvent-induced phase separation (NIPS) occurs during the sulfonation process, and the formation mechanism of surface and cross-sectional morphologies is discussed. Furthermore, it is assumed that the air is trapped in the microsized pores, leaving the surface of the 3D porous network in the Cassie-wetting state. All of these preliminary results throw light on the nature of the sulfonation process and may guide further modification of the structures of sulfonated PEEK.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Sample Preparationmentioning

confidence: 99%

See 1 more Smart Citation

The Formation Process and Mechanism of the 3D Porous Network on the Sulfonated PEEK Surface

Xie,

Xiao,

Song

et al. 2024

ACS Appl. Mater. Interfaces

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“…Therefore, this chemical method can be extended to other polymer implants. Positive antibacterial groups, such as -SO 3 H, -OH, and -COOH, can also be introduced on the surface of PEEK, which can cause electrostatic repulsion and negatively charged bacterial cell membranes to generate a zeta potential difference ( Liu et al, 2021a ; Zhang et al, 2022 ). However, the introduction of these functional groups lacks long-term in vivo experimental verification.…”

Section: Modification For Enhanced Biopropertiesmentioning

confidence: 99%

State-of-the-art polyetheretherketone three-dimensional printing and multifunctional modification for dental implants

Chen,

Ren,

Shi

et al. 2023

Front. Bioeng. Biotechnol.

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Polyetheretherketone (PEEK) is a high-performance thermoplastic polymer with an elastic modulus close to that of the jawbone. PEEK has the potential to become a new dental implant material for special patients due to its radiolucency, chemical stability, color similarity to teeth, and low allergy rate. However, the aromatic main chain and lack of surface charge and chemical functional groups make PEEK hydrophobic and biologically inert, which hinders subsequent protein adsorption and osteoblast adhesion and differentiation. This will be detrimental to the deposition and mineralization of apatite on the surface of PEEK and limit its clinical application. Researchers have explored different modification methods to effectively improve the biomechanical, antibacterial, immunomodulatory, angiogenic, antioxidative, osteogenic and anti-osteoclastogenic, and soft tissue adhesion properties. This review comprehensively summarizes the latest research progress in material property advantages, three-dimensional printing synthesis, and functional modification of PEEK in the fields of implant dentistry and provides solutions for existing difficulties. We confirm the broad prospects of PEEK as a dental implant material to promote the clinical conversion of PEEK-based dental implants.

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“…Thus, PEEK has been identified as a biologically inert material [ 7 , 8 ]. Some studies showed that implant infection [ 9 ] and poor osseointegration [ 10 ] were the main factors leading to implant failure. The application scenarios of implanted materials are mainly trauma, infection, and lower immune function of the patient.…”

Section: Introductionmentioning

confidence: 99%

Latest advances: Improving the anti-inflammatory and immunomodulatory properties of PEEK materials

Zhang

Zheng

et al. 2023

Materials Today Bio

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Treatment methods toward improving the anti-infection ability of poly(etheretherketone) implants for medical applications

Cited by 14 publications

References 148 publications

The Formation Process and Mechanism of the 3D Porous Network on the Sulfonated PEEK Surface

The Formation Process and Mechanism of the 3D Porous Network on the Sulfonated PEEK Surface

State-of-the-art polyetheretherketone three-dimensional printing and multifunctional modification for dental implants

Latest advances: Improving the anti-inflammatory and immunomodulatory properties of PEEK materials

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