Treatment of Acne vulgaris with the Retinoic Acid Derivative Ro 11-1430

Christiansen, Jørgen V.; Holm, Per Sonne; Reymann, Flemming

doi:10.1159/000251112

Cited by 22 publications

(9 citation statements)

References 2 publications

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“…[3] did not find any significant difference as regards the clinical effect between retinoic acid and Ro 11-1430, but Ro 11-1430 had a better local tolerance. This controlled multicenter trial shows a more moderate effect of Ro 11-1430 compared with that of retinoic acid.…”

Section: Commentmentioning

confidence: 64%

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The Retinoic Acid Derivative Ro 11-1430 in Acne vulgaris

Christiansen¹,

Holm²,

Reymann³

1977

Dermatology

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In a double-blind controlled multicenter trial consisting of 257 patients with acne vulgaris an 8-week topical treatment with the retinoic acid derivative Ro 11-1430 (0.1% lotion) was compared with vitamin A acid (0.05% lotion) and the lotion alone (placebo). In reducing the number of comedones vitamin A acid was superior to Ro 11-1430, which was significantly better than placebo. The reduction in number of papules and pustules was not statistically significant on either treatment. Local side effects, i.e. erythema, desquamation, burning and pruritus occurred more frequently and were more severe on vitamin A acid than on Ro 11-1430 and placebo which did not differ. No correlation was found between incidence and severity of local reactions and therapeutic effect.

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Section: Commentmentioning

confidence: 64%

“…In a controlled clinical trial, C hris tiansen et al [3] demonstrated that this was the case also in patients with acne vulgaris. Owing to the limited number of patients, the trial was unable to determine whether or not the diminished frequency of side effects had been obtained without a concurrent loss of therapeutic effect.…”

Section: Retinoic Acidmentioning

confidence: 91%

The Retinoic Acid Derivative Ro 11-1430 in Acne vulgaris

Christiansen¹,

Holm²,

Reymann³

1977

Dermatology

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“…The efficacy of therapy was evaluated at allocation and after 2, 4, and 6-8 weeks by a within-patient and a between-patient comparison based on a counting of the total number of acne elements on a limited area (19.6 cm2) as well as of the number of comedones, papules, and pustules, separately [1], The intensity of local reactions was ranked according to the four-point scale: none, slight, moderate, and severe.…”

Section: Methodsmentioning

confidence: 99%

“…Christiansen et al [ 1,2] found that the retinoic acid derivative Ro 11 -1430 (0.1% solution) caused less severe and less frequent local reactions, but had a lower therapeutic effect than retinoic acid (0.05% solution) in patients with acne vulgaris. The incidence and severity of side-effects were correlated with a higher non-compliance rate in the retinoic acid group [2].…”

mentioning

confidence: 99%

The Retinoic Acid Derivative Ro 11-1430 (Tasmademi®) in Patients with Acne vulgaris not Tolerating Retinoic Acid

Christiansen¹,

Gadborg²,

Hattel³

et al. 1979

Dermatology

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In a double-blind randomized comparative multicenter trial, consisting of 29 patients with acne vulgaris who were unable to tolerate daily applications of retinoic acid, the retinoic acid derivative Ro 11–1430 (0.1% vanishing cream) was compared in a 6–8 weeks topical treatment with vanishing cream alone (placebo). Regarding efficacy, for most criteria measured the response was always better with Ro 11–1430 than with placebo, although the differences were not always statistically significant for several reasons, one probably being the small number of patients in the trial. Regarding tolerance, both treatments were satisfactory. Ro 11–1430 and placebo did not differ significantly regarding frequency and severity of erythema, desquamation and burning. These results suggest that treatment with Ro 11–1430 should be considered in acne patients who are unable to use retinoic acid due to severe local reactions.

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“…The ther apeutic effects of topically applied 0.1 % mo tretinide and 0.05% retinoic acid on acne vulgaris have been found to be similar [Christiansen et al, 1976[Christiansen et al, , 1977Braathen et al 1978], Benzoyl peroxide administered topically has been shown to have a good therapeutic effect on acne vulgaris [Liddel, 1974;Jo hansson and Sulionen, 1978], However, lo cal side-effects in the form of skin irritation were noted in 41% of the patients in the stu dy, and this effect seemed to be a toxic and not an allergic reaction.…”

Section: Introductionmentioning

confidence: 91%