Treatment of cholelithiasis with acetylcysteine, a new gallstone solvent

Moriyasu, Akihito; Ise, Hideo; Suzuki, Noriyoshi; Matsuno, Seiki

doi:10.1007/bf02391104

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Acetylcysteine is a mucolytic drug that has been used to thin mucous, and specifically in the gall bladder as a gall stone solvent. 11 Although we were unable to find any cholecystoliths, or observe drainage of contrast into the small intestine, acetylcysteine is also reported to assist with gall stone dissolution. Given the unknown nature of the obstruction (debris or gall stones) and the thick fluid draining from the gall bladder, we elected to use a 10% solution of acetylcysteine to assist with the gall bladder lavages for the first 4 days after surgery.…”

Section: Discussionmentioning

confidence: 64%

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Septic cholecystitis in a goat

Biedrzycki

Roe

2022

Vet Record Case Reports

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A 3-year-old, female, Nigerian dwarf goat presented for the evaluation of a swelling in the right flank. No other clinical signs were apparent. Biochemical changes were minimal and included a hyperfibrinogenemia and a leukocytosis characterised by neutrophilia. Diagnostic imaging included ultrasonography and computed tomography, which demonstrated a grossly distended gall bladder. Cholecystectomy could not be performed due to extensive adhesions, so the case was managed successfully via tube cholecystostomy, lavage, open drainage and systemic antibiotics for 5 weeks. Eight months after treatment, the goat continues to gain weight and is clinically well otherwise. Although rare, the successful treatment of septic cholecystitis is possible in goats.

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Section: Discussionmentioning

confidence: 64%

“…Acetylcysteine is a mucolytic drug that has been used to thin mucous, and specifically in the gall bladder as a gall stone solvent 11 . Although we were unable to find any cholecystoliths, or observe drainage of contrast into the small intestine, acetylcysteine is also reported to assist with gall stone dissolution.…”

Section: Discussionmentioning

confidence: 65%

Septic cholecystitis in a goat

Biedrzycki

Roe

2022

Vet Record Case Reports

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Hepatobiliary Disease in Cystic Fibrosis

Strandvik¹

2003

Diseases of the Liver and Biliary System in Children

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Why laparoscopic cholecystectomy today?

Sándor

Záborszky

et al. 1996

Surg Today

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Traditional open cholecystectomy became the "gold standard" of surgical treatment for symptomatic gallstone disease during the last century. In spite of its good results, clinicians have been trying to establish effective nonsurgical methods of eliminating gallstones. Although oral, percutaneous, or retrograde litholysis can be used effectively for cholesterol stones, these represent only 10% of all gallstones. Moreover, intracorporeal lithotripsy is an invasive method, and while extracorporeal shock wave lithotripsy is a promising procedure, even after careful selection, only 70%-80% of the patients become stone-free within 1 year. In fact, none of the methods which leave the gallbladder intact are free of complications, and they are followed by 50% stone recurrence within 5 years. Since 1987, laparoscopic cholecystectomy has become the procedure of choice as it is safe and only minimally invasive. We believe that the laparoscopic technique is a promising way to the surgery of the future.

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Treatment of cholelithiasis with acetylcysteine, a new gallstone solvent

Abstract: An improved technique for making thin sections of gallstones has enabled us to examine their morphology microscopically. Using this technique in various types of gallstones, we found a network of mucin, which was considered to play an important role in gallstone formation.

Cited by 3 publications

References 10 publications

Septic cholecystitis in a goat

Septic cholecystitis in a goat

Hepatobiliary Disease in Cystic Fibrosis

Why laparoscopic cholecystectomy today?

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