Treatment of Experimental Aneurysms Using Collagen-coated Microcoils

Usefulness of the Behavior of Fibroblast Attachment to Coils in Thermoreversible Gelation Polymer for Aneurysmal Coil Treatment

“…In vivo however, endothelial overgrowth from the aneurysm orifice margins progressively covered the already fibrotically organised parts of the cloth inspite the presence of fresh thrombus in some parts of the occluded aneurysm [12]. In endothelialization a fibrin membrane across the orifice of aneurysm appeared 36 hours after embolization [29] and afterward endothelial cells seemed to elongate on that membrane [30]. This endothelialization is the final stage of aneurysm exclusion from the parent vessel circulation [11].…”

Endovascular Treatment of Experimental Aneurysms with Use of Fibroblast Transfected with Replication-Deficient Adenovirus Containing Bone Morphogenetic Protein-13 Gene

“…On the basis of this theory, various coil modifications have been tested in animal models. In a surgically created aneurysmal model in swine, Dawson et al 5 showed that collagen-coated microcoils resulted in an aneurysm completely occluded with a collagen-rich fibrous scar. Szikora et al 7 showed that placement of collagen filaments in the lumen of the Guglielmi detachable coil resulted in improved fibrosis in the immediate vicinity of the coil.…”

“…3,4 Thus, investigators have proposed modifications aimed at increasing the coil's "biologic activity," defined as improved thrombus organization, collagen formation, or endothelialization within and adjacent to the aneurysmal cavity. [3][4][5][6][7][8][9][10][11][12] Previous groups 12 have proposed the delivery of bioactive proteins such as vascular endothelial growth factor (VEGF) to enhance healing of cerebral aneurysms. However, the amount of protein that can be effectively delivered to an aneurysm with use of a platinum microcoil is severely limited, and the effect diminishes with time.…”

Endovascular Histologic Effects of Ultrathin Gold- or Vitronectin-Coated Platinum Aneurysm Coils in a Rodent Arterial Occlusion Model: A Preliminary Investigation

“…[2][3][4][5][6][7][8][9][10][11][12][13] Novel stratagems to improve the efficacy of platinum coils have consisted chiefly of coating platinum coils with materials thought likely to provoke a more desirable cascade of histologic reaction. 8,12,[14][15][16][17][18][19][20][21][22][23][24] Some new-generation bioactive coils presently being used clinically, however, have failed to demonstrate improved efficacy in decreasing the recanalization rate over bare platinum coils, suggesting the need for continued investigation of novel coil-coating materials and technology. [25][26][27] Gold has excellent fluoroscopic visibility and has been demonstrated to increase neointimal thickness and vascular restenosis when applied to stainless steel stents.…”