The management of advanced knee osteoarthritis remains a subject of discussion. The use of total knee prosthesis is a solution to improve the quality of life's patients. The aim of this work was to describe the epidemiology and evaluate the results of a series of 60 cases advanced knee osteoarthritis, treated with total knee prostheses in the department. This was a retrospective study conducted from May 2016 to May 2020 at the Owendo University Teaching Hospital. The study concerned the analysis of the files of patients operated on for advanced AHLBACK stage III to V knee osteoarthritis by total knee prostheses. The study variables collected from a survey sheet were analyzed using Excel version 2016 software. We collected 60 patients including 42 women (70%) and 18 men (30%). The average age of the patients was 63.5 years. All patients were operated on under regional anesthesia in the supine position without a pneumatic tourniquet. The surgical site was approached anteromedially. The implant was placed in the left knee in 53.3% (n=32) and in the right knee in 46.7% (n=28). The functional results evaluated according to the International Knee Society (IKS) score were favorable in 96.7% (n=58). In conclusion, knee osteoarthritis is a condition of elderly females. Its treatment, using total knee prostheses, evaluated according to the IKS score, gave satisfactory results.