Treatment of hypertrophic osteoarthropathy in the case of pulmonary metastasis secondary-to-nasopharyngeal carcinoma with zoledronic acid: an enlightening experience

Sonthalia, Nikhil; Mukherjee, Kasturi; Saha, Avishek; Talukdar, Arunansu

doi:10.1136/bcr-2012-006759

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…По данным некоторых исследований, терапия бисфосфонатами (золедроновой кислотой, памидроновой кислотой) может быть эффективна как при первичной, так и при вторичной гипертрофической остеоартропатии [24][25][26]. Помимо ингибирования резорбции костной ткани остеокластами бисфосфонаты обладают противовоспалительным действием, а также снижают уровень фактора роста эндотелия сосудов [27].…”

Section: Discussionunclassified

Features of the clinical course of pachydermoperiostosis with a verified mutation in the European type gene

Frolova,

Golounina,

Mamedova

et al. 2023

Osteopor Bone Dis

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Pachydermoperiostosis (primary hypertrophic osteoarthropathy) is an orphan disease, the main clinical manifestations of which include pin-shaped deformity of the fingers according to the type of «drumsticks», periostosis (non-inflammatory changes of the periosteum) of tubular bones, pachydermia of the face (hypertrophy and hyperplasia of all skin layers). Two genes associated with the development of pachydermoperiostosis are known — HPGD and SLCO2A1. Mutations in these genes lead to impaired prostaglandin E2 metabolism. This article describes a clinical case of a patient with pachydermoperiostosis, in which two mutations in the HPGD gene were detected during a molecular genetic study: in 1 exon (chr4-174522451-T-A, NM_000860.6:c.1A>T) and in 2 exon (chr4-174521985-AG-, NM_000860.6:c.175_176del) in compound-heterozygous state, while the c.1A>T mutation was previously described once, and the revealed biallelic combination of mutations in the HPGD gene was not previously found in the literature. This clinical case of pachydermoperiostosis is the second described in the Russian population, and the first with confirmed mutations in the HPGD gene. The article expands the knowledge about the correlation of genotype and phenotype in pachydermoperiostosis, which contributes to a faster and more correct interpretation of genetic information during genetic counseling.

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Section: Discussionunclassified

Features of the clinical course of pachydermoperiostosis with a verified mutation in the European type gene

Frolova,

Golounina,

Mamedova

et al. 2023

Osteopor Bone Dis

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“…However, patients respond differently, and sometimes total relief is not achieved and the intense arthralgia subsists. In cases where pain is refractory to conventional analgesia, case studies have reported success with bisphosphonates including zoledronic acid and pamidronate [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…Terapia farmakologiczna na ogół obejmuje konwencjonalne zastosowanie NSAID, opioidów i glikokortykoidów, jednak skuteczność przeciwbólowa powyższych metod w przypadku bólu stawowego towarzyszącego HOA jest zmienna. W przypadkach występowania bólu opornego na konwencjonalną analgezję, przeprowadzone analizy dowiodły skuteczności stosowania bisfosfonianów, w tym kwasu zolendronowego i pamidronatu [7][8][9].…”

Section: Dyskusjaunclassified

Hypertrophic osteoarthropathy as a paraneoplastic manifestation of lung cancer.

Masłowska¹,

Rutkowski²,

Brunetto³

2020

Palliat Med Pract

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Hypertrophic osteoarthropathy (HOA) is a syndrome that consists of periostitis, digital clubbing, and painful polyarthropathy. The management and prognosis of HOA is dependent on the underlying disease process. Recognising and treating it accordingly will reduce the symptom burden of patients. We present a case of a patient diagnosed with non-small cell lung cancer and HOA suffering from severe pain, and review specific therapies for the management of HOA-related pain.

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“…A variety of diseases, including cyanotic heart disease [3], pulmonary metastasis, and notably lung cancer [4], have been recognized as etiologies of the secondary form. Liver cirrhosis has been identified as a culprit in other cases as well [5].…”

Section: Discussionmentioning

confidence: 99%

Primary Idiopathic Osteoarthropathy: Could It Be Related to Alcoholism?

Alnimer

Subedi

Dawood

et al. 2017

Case Reports in Rheumatology

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Background. Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of the skin and bony structures at the distal extremities resulting in digital clubbing, periosteal bony reaction, and joint effusion. It can be primary (idiopathic) without any clear identifiable etiology as well as secondary to variety of systemic diseases most notably lung pathology. Case Presentation. We describe a rare case of primary idiopathic osteoarthropathy in a male patient who presented with severe pain and tenderness in his legs. His history was significant for long standing alcoholism. Physical examination showed severe fingers and toes clubbing. He reported similar changes in his mother. Clinical and radiological findings were remarkable for distal leg tenderness and diffuse periosteal bony reactions, respectively. Computerized tomography scan failed to show any pathology apart from fatty liver infiltration. In the absence of obesity or diabetes, this was consistent with alcoholic steatosis. He was started on nonsteroidal anti-inflammatory drug which dramatically improved his symptoms. Conclusion. Primary hypertrophic osteoarthropathy should be considered in a previously healthy person presenting with bony pain and finger clubbing especially after ruling out the common secondary causes. Moreover, alteration of prostaglandin metabolism secondary to alcoholic consumption might be a contributing factor.

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Treatment of hypertrophic osteoarthropathy in the case of pulmonary metastasis secondary-to-nasopharyngeal carcinoma with zoledronic acid: an enlightening experience

Cited by 8 publications

References 11 publications

Features of the clinical course of pachydermoperiostosis with a verified mutation in the European type gene

Features of the clinical course of pachydermoperiostosis with a verified mutation in the European type gene

Hypertrophic osteoarthropathy as a paraneoplastic manifestation of lung cancer.

Primary Idiopathic Osteoarthropathy: Could It Be Related to Alcoholism?

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