Treatment of oral lichen planus: a narrative review

Oberti, Luca; Gabrione, Federica; Lucchese, Alberta; Stasio, Dario Di; Lauritano, D

doi:10.3389/conf.fphys.2019.27.00004

Cited by 3 publications

(3 citation statements)

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“…Non‐pharmacological measures for reducing the morbidity in patients with lichen planus include maintaining good oral hygiene, cessation of smoking, avoidance of appliances causing trauma 6 . Pharmacological treatment using corticosteroids, calcineurin inhibitors, retinoids, photodynamic therapy, curcumin, vitamin D, hyaluronic acid has been tried in clinical trials with variable success 7 . The mode of actions of the commonly used drugs/drug classes for treating oral lichen planus are listed in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Interventions for oral lichen planus: A systematic review and network meta‐analysis of randomized clinical trials

Sridharan

Sivaramakrishnan

2021

Australian Dental Journal

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Background Corticosteroids, calcineurin inhibitors, vitamin D, photodynamic therapy, herbal drugs are some of the interventions tried in clinical trials for treating oral lichen planus. We carried out the present network meta‐analysis to compare the above‐mentioned interventions. Methods Electronic databases were searched for randomized clinical trials evaluating interventions in patients with symptomatic oral lichen planus. Clinical resolution, clinical score, pain resolution, pain score, and adverse effects were the outcomes evaluated. Results Fifty‐five (2831 patients) trials were included. Corticosteroids (OR: 13.6; 95% CI: 1.2, 155.4), pimecrolimus (OR: 14.7; 95% CI: 1.7, 125), purslane (OR: 18.4; 95% CI: 3.5, 97), and ozonized water/corticosteroids (OR: 52; 95% CI: 1.4, 1882.6) had better rates of clinical resolution compared to placebo. Corticosteroids (OR: 3.18; 95% CI: 1.2, 8.43), ozonized water/corticosteroids (OR: 9.9; 95% CI: 2.7, 36.2), aloe vera (OR: 13; 95%: 1.5, 111.8), pimecrolimus (OR: 18.8; 95% CI: 2, 177.4) and hyaluronic acid (OR: 24.8; 95% CI: 1.3, 457.6) were significantly associated with superior rates of pain resolution compared to placebo. Pimecrolimus and cyclosporine were associated with significantly higher risk of adverse effects than placebo. Conclusion Topical corticosteroids were the most effective drug class for treating oral lichen planus.

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Section: Introductionmentioning

confidence: 99%

Interventions for oral lichen planus: A systematic review and network meta‐analysis of randomized clinical trials

Sridharan

Sivaramakrishnan

2021

Australian Dental Journal

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“…3 Harvard Medical School, Boston, MA, USA. 4 Ministry of Health and Population, Cairo, Egypt. 5 • support for research data, including large and complex data types • gold Open Access which fosters wider collaboration and increased citations maximum visibility for your research: over 100M website views per year…”

Section: Supplementary Informationmentioning

confidence: 99%

“…The exact etiology of OLP is unknown, and there is currently no known cure [2]. The primary therapeutic goal is symptom management and current treatment options include corticosteroids, calcineurin inhibitors, retinoids, photodynamic therapy, and natural alternatives, although with varying degrees of efficacy [4,5]. A recent metaanalysis of 55 RCTs compared different interventions and concluded that topical corticosteroids were the most effective treatment modality [6].…”

Section: Introductionmentioning

confidence: 99%

Oral lichen planus: comparative efficacy and treatment costs—a systematic review

et al. 2022

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Objective To compare the reported efficacy and costs of available interventions used for the management of oral lichen planus (OLP). Materials and methods A systematic literature search was performed from database inception until March 2021 in MEDLINE via PubMed and the Cochrane library following PRISMA guidelines. Only randomized controlled trials (RCT) comparing an active intervention with placebo or different active interventions for OLP management were considered. Results Seventy (70) RCTs were included. The majority of evidence suggested efficacy of topical steroids (dexamethasone, clobetasol, fluocinonide, triamcinolone), topical calcineurin inhibitors (tacrolimus, pimecrolimus, cyclosporine), topical retinoids, intra-lesional triamcinolone, aloe-vera gel, photodynamic therapy, and low-level laser therapies for OLP management. Based on the estimated cost per month and evidence for efficacy and side-effects, topical steroids (fluocinonide > dexamethasone > clobetasol > triamcinolone) appear to be more cost-effective than topical calcineurin inhibitors (tacrolimus > pimecrolimus > cyclosporine) followed by intra-lesional triamcinolone. Conclusion Of common treatment regimens for OLP, topical steroids appear to be the most economical and efficacious option followed by topical calcineurin inhibitors. Large-scale multi-modality, prospective trials in which head-to-head comparisons interventions are compared are required to definitely assess the cost-effectiveness of OLP treatments.

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The content of the total protein, protein fractions and blood serum proteins in patients with different forms of lichen ruber planus

Бараннік

Tsymbaliuk

Manukhina

et al. 2021

Modern Medical Technology

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Purpose of the study. Establishing the role of processes of proteolysis of mixed saliva in the development and course of lichen planus of the oral mucosa. Materials and methods. A comprehensive examination of 102 patients with lichen planus aged 21 to 70 years and 20 people in the control group, whose age and sex composition corresponded to that in the study group. BioRad (USA) reagent kits were used to determine the total protein content of mixed saliva. The content of protein fractions of mixed saliva was determined by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. Determination of serum proteins in mixed saliva was performed by quantitative (cross) immunoelectrophoresis. Results. In patients with lichen planus, the overall proteolytic activity of mixed saliva increases with a significant increase in the concentration of α1proteinase inhibitor, especially in exudative hyperemic and erosiveulcerative forms of the disease. Diffusion of α1proteinase inhibitor into mixed saliva increases its antiproteolytic potential and has a protective character. The content of albumin and ceruloplasmin in the mixed saliva of patients with lichen planus increases depending on the severity of the disease: typical, hyperkeratotic, exudativehyperemic, erosiveulcerative. Conclusions. Mixed saliva of patients with lichen planus in contrast to patients in the control group is characterized by the predominance of low molecular weight proteins (20–79 kDa) over high molecular weight. The level of albumin, α1proteinase inhibitor and ceruloplasmin in the mixed saliva of patients with lichen planus increases and correlates with the severity of the disease. The content of IgA in the mixed saliva of patients with lichen planus increases, depending on the form of the disease.

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Treatment of oral lichen planus: a narrative review

Cited by 3 publications

References 0 publications

Interventions for oral lichen planus: A systematic review and network meta‐analysis of randomized clinical trials

Interventions for oral lichen planus: A systematic review and network meta‐analysis of randomized clinical trials

Oral lichen planus: comparative efficacy and treatment costs—a systematic review

The content of the total protein, protein fractions and blood serum proteins in patients with different forms of lichen ruber planus

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