Treatment Trials for Viral Conjunctivitis: What We Have Learned and How We can Improve

Cho, Kyongjin; Kuo, Irene

doi:10.1097/coa.0000000000000006

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Because viral etiology is thought to be predominant in cases of conjunctivitis in the United States, indiscriminate dispensing of antibiotic eyedrops for conjunctivitis in the United States may be inappropriate. 3 , 29 , 30 However, testing for pathogen identification is not performed routinely for conjunctivitis in any location. Thus, targeted treatment toward definitively identified pathogens is rarely possible.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger

Amza,

Nassirou,

Kadri

et al. 2023

The American Journal of Tropical Medicine and Hygiene

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ABSTRACT. Infectious conjunctivitis outbreaks remain a public health burden. This study focuses on the pathogen and antimicrobial resistance (AMR) profiles identified in Niger. Sixty-two patients with acute infectious conjunctivitis who presented to health posts were enrolled from December 2021 to May 2022. Nasal and conjunctival swabs were obtained from each patient. Unbiased RNA deep sequencing (RNA-seq) was used to identify associated pathogens. A pathogen was identified in 39 patients (63%; 95% CI, 50–74). Of those, an RNA virus was detected in 23 patients (59%; 95% CI, 43–73). RNA viruses were diverse and included human coronaviruses (HCoVs): SARS-CoV-2, HCoV-229E, HCoV-HKU1, and HCoV-OC43. A DNA virus was identified in 11 patients (28%; 95% CI, 17–44). Of those, four patients had a coinfection with an RNA virus and two patients had a coinfection with both an RNA virus and a bacterium. DNA viruses were predominantly human herpesvirus (cytomegalovirus, Epstein–Barr virus, human herpesvirus 8) and human adenovirus species B, C, and F. Eighteen patients (46%; 95% CI, 32–61) had a bacteria-associated infection that included Haemophilus influenza, Haemophilus aegyptius, Staphylococcus aureus, Streptococcus pneumoniae, and Moraxella spp. Antimicrobial resistance determinants were detected in either the conjunctiva or nasal samples of 20 patients (32%; 95% CI, 22–45) and were found to be more diverse in the nose (Shannon alpha diversity, 1.12 [95% CI, 1.05–1.26] versus 1.02 [95% CI, 1.00–1.05], P = 0.01). These results suggest the potential utility of leveraging RNA-seq to surveil pathogens and AMR for ocular infections.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger

Amza,

Nassirou,

Kadri

et al. 2023

The American Journal of Tropical Medicine and Hygiene

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A Review: Pink Eye Outbreak in India

J. Barad,

M. Raval,

J. Tank

et al. 2024

International Journal of Innovative Science and Research Techno

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Conjunctivitis or ‘Pink Eye’ is the inflammation or infection of the Conjunctivitis, the membrane covering the white part of the inner eyelid. The Conjunctiva is the thin, clear, mucus membrane that covers the white of the eye and the inner eyelid. Viruses causes up to 80% of all cases acute Conjunctivitis. All broad- spectrum antibiotic eyedrops seen in general to be effective in treating bacterial Conjunctivitis. Acute bacterial Conjunctivitis is common in children, with more than 50% of conjunctivitis cases beings bacterial in origin as per the mentioned evidences the present Review was designed to study outbreak of pink eye in the years 2023 considering past 4 to 5 years consist in July 2023 conjunctivitis cases data in Gujrat [India]: 2.17 lac, Delhi NCR[India]:1032, Maharashtra [India]: 87.761 K, Lucknow [ Up-India]: 40 to 46 Daily. The diseases cause normally 7 to 10 days.

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Treatment Trials for Viral Conjunctivitis: What We Have Learned and How We can Improve

Cited by 2 publications

References 19 publications

Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger

Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger

A Review: Pink Eye Outbreak in India

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