Treatment With Acyclovir Does Not Affect Orogenital Ulcers in Behcçet's Syndrome: A Randomized Double-Blind Trial

Davies, U M; Palmer, R. F.; Denman, A. M.

doi:10.1093/rheumatology/27.4.300

Cited by 63 publications

(22 citation statements)

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“…Topical treatment with CS, topical anesthetics, antimicrobial mouthwashes, sucralfate [Keogan, 2009] and topical granulocyte colony-stimulating factor [Bacanli et al 2006] can be helpful in the management of mucocutanous lesions. Additionally, a number of antibiotics and antivirals, based on the possible role of herpes and Streptococcus sanguinis in the pathogenesis of the disease, have been used primarily for the treatment of mucocutaneous manifestations with variable responses [Calguneri et al 1996a[Calguneri et al , 1996bDavies et al 1988] and thus are not part of the routine care of patients with BD.…”

Section: Other Therapiesmentioning

confidence: 99%

Update on the therapy of Behçet disease

Saleh

Arayssi

2014

Therapeutic Advances in Chronic Disease

115

101

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Behçet disease is a chronic inflammatory systemic disorder, characterized by a relapsing and remitting course. It manifests with oral and genital ulcerations, skin lesions, uveitis, and vascular, central nervous system and gastrointestinal involvement. The main histopathological finding is a widespread vasculitis of the arteries and veins of any size. The cause of this disease is presumed to be multifactorial involving infectious triggers, genetic predisposition, and dysregulation of the immune system. As the clinical expression of Behçet disease is heterogeneous, pharmacological therapy is variable and depends largely on the severity of the disease and organ involvement. Treatment of Behçet disease continues to be based largely on anecdotal case reports, case series, and a few randomized clinical trials.

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Section: Other Therapiesmentioning

confidence: 99%

Update on the therapy of Behçet disease

Saleh

Arayssi

2014

Therapeutic Advances in Chronic Disease

115

101

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“…Innumerable attempts to demonstrate an infectious agent in the eye have proven fruitless. Additionally, a recently completed double masked randomized trial in which acylovir was used to treat the orogenital ulcers seen in this disease failed to show any efficacy [12]. However, an environmental role must be considered.…”

Section: The Environmentmentioning

confidence: 99%

The natural history of uveitis

1990

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Inflammatory diseases of the eye were known to the ancients, but only recently have the underlying mechanisms to this problem become better defined. During the middle portion of this century, most cases of uveitis thought to be caused by infectious agents, such as those responsible for syphilis and tuberculosis. Since then, it has become clear that endogenous mechanisms of immunomodulation play an important role in these disorders, which along with environmental and genetic factors make up an important triad. Animals studies have indicated the pivotal role of the T-cell in many of these disorders. The development of T-cell lines has helped to further delineate cell to cell interactions that occur during an ocular inflammatory event. The presence in the eye of uveitogenic antigens raises the strong possibility of autoimmune driven processes as well, similar to what is seen in the animal models. The better understanding of ocular inflammatory mechanisms has led to improved therapeutic strategies, including Sandimmune, and more recently Cyclosporine G, a related compound that may be less nephrotoxic. Newer therapeutic strategies will focus on even more novel modes of immunomodulation, probably without the use of medications.

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“…By use of DNA-DNA dot blotting and polymerase chain reaction (PCR) analysis, HSV DNA also was detected in leukocytes and saliva from patients with BD [8,9]. Treatment with acyclovir, which is of proven efficacy in the treatment of HSV infection, did not much alleviate the frequency or severity of orogenital ulceration or other clinical features of BD [10]. Lymphocyte dysfunction has been reported by several research groups.…”

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confidence: 99%

Expression of Th2 Cytokines Decreases the Development of and Improves Behçet's Disease–Like Symptoms Induced by Herpes Simplex Virus in Mice

et al. 2001

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In the etiology of Behçet's disease (BD), viral infection has long been postulated as a contributing factor, and viral involvement has been demonstrated. However, viral infection alone is not sufficient to explain the pathogenesis of BD, and some evidence suggests that immunologic abnormalities are also important. To study the possible role of immune regulation in the development of BD-like symptoms induced by herpes simplex virus inoculation in ICR mice, macrophages were deleted by use of liposome-encapsulated clodronate (lip-Cl(2)MDP). Treatment with lip-Cl(2)MDP suppressed the development of BD-like symptoms, and this suppression was correlated with the induction of interleukin-4 expression in mouse spleens. When the Th2 adjuvant ovalbumin (OVA)-alum was injected into mice with BD-like symptoms, their cutaneous symptoms improved. Adoptive transfer with splenocytes from OVA-alum-injected mice also resulted in improvement. These findings suggest that up-regulated Th2 cytokine expression can attenuate the development of and improve some BD-like symptoms.

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Treatment With Acyclovir Does Not Affect Orogenital Ulcers in Behcçet's Syndrome: A Randomized Double-Blind Trial

Cited by 63 publications

References 0 publications

Update on the therapy of Behçet disease

Update on the therapy of Behçet disease

The natural history of uveitis

Expression of Th2 Cytokines Decreases the Development of and Improves Behçet's Disease–Like Symptoms Induced by Herpes Simplex Virus in Mice

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