Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis

Bhatia, Madhav; Ramnath, Raina Devi; Chevali, Lakshmi; Guglielmotti, Angelo

doi:10.1152/ajpgi.00435.2004

Cited by 127 publications

(96 citation statements)

References 29 publications

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“…These conditions will lead SIRS to progress to MODS. In a previous report, blockade of MCP-1 synthesis protected mice against acute pancreatitis, as evidenced by their attenuated hyperamylasemia, neutrophil sequestration in the pancreas, and pancreatic acinar cell injury/necrosis (Bhatia et al 2005). Thus, a low level of MCP-1 generally indicates better prognosis in infectious diseases.…”

Section: Discussionmentioning

confidence: 84%

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Zhu

Liao

Feng

et al. 2017

Tohoku J. Exp. Med.

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Sepsis is a systemic host response to infection, and patients with sepsis are frequently handled in the intensive care unit. However, mortality related to sepsis remains high throughout the world. In addition, there have been no efficient prognostic biomarkers for sepsis to be employed in clinical practice. We therefore aimed to identify prognostic biomarkers for sepsis using the chemokine/cytokine array. This study included 143 patients with sepsis, who were divided into survivor and nonsurvivor groups according to their 28-day mortality status. The cytokine array analysis was performed with plasma samples from two randomly selected patients in each sepsiofgroup. We thus identified seven cytokines with significantly and consistently different expression levels between nonsurvivors and survivors. The validity of the selected cytokines was then assessed by enzyme-linked immunosorbent assay (ELISA). We finally found monocyte chemoattractant protein 1 (MCP-1) as the most useful biomarker to distinguish the two sepsis groups; namely, non-surviving patients (n = 56) exhibited significantly higher plasma concentrations of MCP-1 compared to survivors (n = 87). MCP-1 is a CC chemokine, a potent chemoattractant that contributes to systemic inflammatory response syndrome. Areas under the receiver operating characteristic curves for prediction of 28-day mortality were 0.763 for MCP-1, 0.680 for the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) score, 0.64 for the Sequential Organ Failure Assessment (SOFA) score, 0.621 for procalcitonin, and 0.785 for MCP-1 plus APACHE II score. In conclusion, we propose that plasma MCP-1 is a useful biomarker in predicting outcome of sepsis.

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Section: Discussionmentioning

confidence: 84%

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Zhu

Liao

Feng

et al. 2017

Tohoku J. Exp. Med.

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“…The factors that determine severity are not clearly understood, but appear to involve a balance between proinflammatory and anti-inflammatory factors. Recent evidence suggests that the balance may be tipped in favor of proinflammatory factors by genetic polymorphisms of inflammatory mediators that increase severity of acute pancreatitis (27,30,31).…”

Section: Pathophysiologymentioning

confidence: 99%

Practice Guidelines in Acute Pancreatitis

Banks

Freeman

2006

Am J Gastroenterology

1,677

980

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“…Bindarit is devoid of any immunosuppressive activity and of effects on arachidonic acid metabolism [10] . This molecule exerted potent anti-inflammatory effects in several experimental diseases, such as arthritis [12] , pancreatitis [13] , coronary in-stent stenosis [14] . In mice with lupus nephritis bindarit reduced MCP-1 upregulation, limited the infiltration of macrophages in the kidney, retarded the development of proteinuria and renal damage, and prolonged animal survival [15,16] .…”

Section: Research Highlightmentioning

confidence: 99%

Renal accumulation of macrophages in experimental polycystic kidney disease is reduced by bindarit

Zoja

Cerullo

2015

Macrophage

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Renal interstitial accumulation of monocytes/macrophages driven by chemoattractants such as monocyte chemoattractant protein-1 (MCP-1)/CCL2, is a characteristic feature of polycistic kidney diseases (PKD). It has been suggested that infiltrating inflammatory cells contribute to promoting cyst growth and renal function impairment in PKD. Recently, we reported that in experimental PKD in PCK rats, bindarit, an inhibitor of MCP-1, effectively decreased the excessive renal expression of MCP-1, and limited interstitial infiltrates of monocytes/macrophages. The anti-MCP-1 therapy displayed an important antiproteinuric effect associated with amelioration of podocyte structure. In this highlight we describe bindarit's effects on the evolution of PKD in PCK rats and on the activity of the drug in cultured podocytes to explain its antiproteinuric effect.

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Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis

Abstract: . Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis.

Cited by 127 publications

References 29 publications

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Practice Guidelines in Acute Pancreatitis

Renal accumulation of macrophages in experimental polycystic kidney disease is reduced by bindarit

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