Trematodiasis in Turkey: comparative efficacy of triclabendazole and niclofolan against natural infections of Fasciola hepatica and F. gigantica in sheep

Güralp, N.; Tinar, Recep

doi:10.1017/s0022149x00028595

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Control Strategies For Trematode Infections1

Applied Both Preventive and Therapeutie Measures Against The1

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1984

2017

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Cited by 16 publications

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“…Neither triclabendazole nor niclofolan have been found to be effective against Dicrocoelium and paramphistome species (Güralp & Tinar, 1984). The drugs of choice for paramphistome infection are resorantel, oxyclozanide and the combination of bithional and levamisole (Aiello, 1998).…”

Section: Control Strategies For Trematode Infectionsmentioning

confidence: 99%

A review of bovine fasciolosis and other trematode infections in Nigeria

Elelu

Eisler

2017

J. Helminthol.

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Section: Control Strategies For Trematode Infectionsmentioning

confidence: 99%

A review of bovine fasciolosis and other trematode infections in Nigeria

Elelu

Eisler

2017

J. Helminthol.

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“…For instanee, in same parts of this country the prevalenee of P. cervi in sheep is 58-100 %. Recently P. ichikawai and Calicophuron daubneyi alsa were found in Anatolian sheep, (2,18).…”

Section: Applied Both Preventive and Therapeutie Measures Against Thementioning

confidence: 99%

THE RELEVAI\CE OF PARASıTIC DISEASES OF ANnvlALS 1:\ TURKEY

Güralp¹

1984

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Fasciola hepatica: Tegumental surface changes in adult and juvenile flukes following treatment in vitro with the sulphoxide metabolite of triclabendazole (Fasinex)

Stitt

Fairweather

1993

Parasitol Res

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The effects of the novel benzimidazole, triclabendazole (Fasinex, Ciba-Geigy), in its active sulphoxide metabolite form (TCBZ-SX), on the tegumental surface of Fasciola hepatica has been examined in vitro. The tegument of adult flukes incubated in TCBZ-SX (50 micrograms/ml) appeared swollen and blebbed after only 6 h. In addition, progressive spine loss at the oral cone was evident following 12 h treatment. After 24 h, the tegumental syncytium and spines had completely sloughed away, leaving an exposed basal lamina and empty spine sockets. Juvenile flukes (3 weeks old) also demonstrated tegumental alterations after treatment with TCBZ-SX (20 micrograms/ml). The syncytium became extremely roughened and corrugated on both dorsal and ventral surfaces after only 3 h. Following 6- and 9-h incubations, there were many deep furrows, which were especially pronounced on the ventral surface, and by 18 h, the juvenile tegument was severely disrupted, especially on the ventral surface. In all cases, the effects were more marked than in the previous incubation periods. The results confirm the potent activity of triclabendazole against F. hepatica and suggest that the tegument of adult and juvenile flukes may be a target organ for this important fasciolicide.

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Trematodiasis in Turkey: comparative efficacy of triclabendazole and niclofolan against natural infections of Fasciola hepatica and F. gigantica in sheep

Cited by 16 publications

References 2 publications

A review of bovine fasciolosis and other trematode infections in Nigeria

A review of bovine fasciolosis and other trematode infections in Nigeria

THE RELEVAI\CE OF PARASıTIC DISEASES OF ANnvlALS 1:\ TURKEY

Fasciola hepatica: Tegumental surface changes in adult and juvenile flukes following treatment in vitro with the sulphoxide metabolite of triclabendazole (Fasinex)

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