Trends and Patterns of Disparities in Oral Cavity and Pharyngeal Cancer in Serbia: Prevalence and Economic Consequences in a Transitional Country

Djordjević, Gordana; Dagović, Aleksandar; Ristić, Vladimir; Kanjevac, Tatjana; Brajković, Denis; Popović, Milica

doi:10.3389/fphar.2017.00385

Cited by 2 publications

(2 citation statements)

References 54 publications

(78 reference statements)

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“…According to recent epidemiological studies, the annual incidence of OSCC increased from 355.000 newly diagnosed cases in 2018 to 377,713 cases in 2020 [ 13 , 35 , 36 ]. The number of OSCC cases has also been increasing in the Serbian population in the last few years [ 22 – 24 ]. According to the Serbian National Cancer Registry data, the age-standardized incidence rate increased from 0.34 in 2010 to 0.37 in 2018 [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to the Serbian National Cancer Registry data, oral and pharyngeal cancer became the eight most common cancer types in males [ 22 – 25 ]. Recent studies in the Serbian population focused on an epidemiological aspect of OSCC in a limited number of patients, including mortality/morbidity rate trends, the detection of risk factors, and the economic aspect of treatment [ 22 , 24 , 26 – 28 ]. One study also investigated the OSCC’s histopathological profile [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Demographic and imaging features of oral squamous cell cancer in Serbia: a retrospective cross-sectional study

Janović,

Bracanović,

Antić

et al. 2024

BMC Oral Health

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Background The mortality of oral squamous cell cancer (OSCC) in Serbia increased in the last decade. Recent studies on the Serbian population focused mainly on the epidemiological aspect of OSCC. This study aimed to investigate the demographic and imaging features of OSCC in the Serbian population at the time of diagnosis. Methods We retrospectively analyzed computed tomography (CT) images of 276 patients with OSCC diagnosed between 2017 and 2022. Age, gender, tumor site, tumor volume (CT-TV, in cm3), depth of invasion (CT-DOI, in mm), and bone invasion (CT-BI, in %) were evaluated. TNM status and tumor stage were also analyzed. All parameters were analyzed with appropriate statistical tests. Results The mean age was 62.32 ± 11.39 and 63.25 ± 11.71 for males and females, respectively. Male to female ratio was 1.63:1. The tongue (36.2%), mouth floor (21.0%), and alveolar ridge (19.9%) were the most frequent sites of OSCC. There was a significant gender-related difference in OSCC distribution between oral cavity subsites (Z=-4.225; p < 0.001). Mean values of CT-TV in males (13.8 ± 21.5) and females (5.4 ± 6.8) were significantly different (t = 4.620; p < 0.001). CT-DOI also differed significantly (t = 4.621; p < 0.001) between males (14.4 ± 7.4) and females (10.7 ± 4.4). CT-BI was detected in 30.1%, the most common in the alveolar ridge OSCC. T2 tumor status (31.4%) and stage IVA (28.3%) were the most dominant at the time of diagnosis. Metastatic lymph nodes were detected in 41.1%. Conclusion Our findings revealed significant gender-related differences in OSCC imaging features. The predominance of moderate and advanced tumor stages indicates a long time interval to the OSCC diagnosis.

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