Trends in Infective Endocarditis in California and New York State, 1998-2013

Toyoda, Nana; Chikwe, Joanna; Itagaki, Shinobu; Gelijns, Annetine C.; Adams, David H.; Egorova, Natalia

doi:10.1001/jama.2017.4287

Cited by 282 publications

(387 citation statements)

References 26 publications

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“…The oral formulation of oxymorphone, Opana ® (Purdue), which came to market in 2006, was modified to an abuse deterrent form in 2012, which coincides with when the increase in OPR injection was reported. These findings mirror those found by Toyoda et al [1] characteristics of the formulation that increases the risk of developing IE. This is a common theme in studies regarding IDUaIE and similar questions were left unanswered in the study by Chambers et al [5].…”

Section: Resultssupporting

confidence: 90%

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A Systematic Review of the Association between Individual Drugs Injected Intravenously and the Development of Infective Endocarditis

Serhan¹,

Silverman²

2017

J Addict Res Ther

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Issues: Infective endocarditis (IE) is a relatively rare disease that is associated with a significant amount of morbidity and mortality. Injection drug use associated IE is increasing in incidence, warranting a better understanding of how the drug of choice impacts the development of IE. Many studies have drawn connections between certain drugs injected intravenously and the development of IE but none have rigorously evaluated why a particular drug might predispose persons who inject drugs (PWID) to IE. Approach:The PubMed database was thoroughly searched using combinations of various key words. Human studies with 20 cases or more of injection drug use associated IE that reported on the drugs injected were analyzed and included in this review. Key findings:No specific drug convincingly showed a strong association between its intravenous use and the development of IE, with studies having contradictory findings. The array of findings reported in the reviewed studies are more likely to be due to the frequency of use of particular drugs and their availability in the respective regions of study than the actual physiologic or pharmacologic properties of the drug. Implications:One trend that requires further investigation is the recent surge in opioid injection that has been linked to increased IE hospitalizations in several studies. Conclusion:Future research should aim to better understand how the preparation and/or physical properties of specific drugs may play a role in the development of IE.

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Section: Resultssupporting

confidence: 90%

“…However, injection drug use (IDU) associated IE (IDUaIE) steadily increased over this period of time [1]. This problem is particularly highlighted in North Carolina where IDUaIE admissions increased twelvefold from 0.2 to 2.7 per 100,000 persons per year from 2010 to 2015.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of the Association between Individual Drugs Injected Intravenously and the Development of Infective Endocarditis

Serhan¹,

Silverman²

2017

J Addict Res Ther

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“…The occurrence of IE among children and adolescents with CHDs was stable in Norway in the period from 1994 to 2016. Similarly, Toyoda et al 23 recently described a stable incidence of IE in the general populations in California and New York State from 1998 to 2013. None of these studies indicated a negative effect of the changes in the guidelines on the incidence of IE.…”

Section: Discussionmentioning

confidence: 74%

“…Toyoda et al 23 recently reported an annual incidence of paediatric IE ranging from 0.3 to 3.3 per 100 000 children and adolescents. The frequency of IE in children without pre-existing heart disease is approximately 0.03 per 10 000 person-years in Norway 2.…”

Section: Discussionmentioning

confidence: 99%

Endocarditis in children and adolescents with congenital heart defects: a Norwegian nationwide register-based cohort study

Jortveit

Klcovansky²,

Eskedal

et al. 2018

Arch Dis Child

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“…The mean age of patients with IE in Europe and the United States was greater than 60 years [3,4]. The fact that a relatively younger age group of IE patients was present in this paper could provide an alternative explanation for the low incidence of stroke as observed in our sample population.…”

Section: Discussionmentioning

confidence: 72%

Stroke in Patients with Infective Endocarditis: A 15-Year Single-Center Cohort Study

Cao

Liu

2018

Eur Neurol

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Objective: To explore the relationship between infective endocarditis (IE) and stroke. Methods: The clinical data of patients diagnosed with IE from January 2003 to December 2017 in Beijing Anzhen Hospital Affiliated to Capital Medical University were retrospectively analyzed. Results: A total of 861 patients (mean age: 40.79 ± 16.27 [SD]) with IE was recruited. Vegetations were confirmed in 97.32% of all the patients, among whom 296 were diagnosed with congenital heart disease and another 53 with rheumatic valvular disease. The most common pathogens were Streptococcus, Staphylococcus, and various types of fungi (13.12, 7.31, and 1.16% respectively). Out of the 138 patients diagnosed with stroke, 101 cases were of ischemic stroke, 23 cases were of hemorrhagic stroke, and 12 cases were of concurrent ischemic and hemorrhagic stroke. There were 31 patients who had infarction lesions in more than 2 vascular systems. The mean age of stroke patients was significantly higher than that of patients without stroke (45.76 ± 17.88 vs. 39.83 ± 15.77, p = 0.000). The incidence of mitral valve vegetation (57.24 vs. 43.01%, p = 0.002), atrial fibrillation (4.34 vs. 1.38%, p = 0.018), fungal infection (2.89 vs. 0.83%, p = 0.038) in patients with stroke was significantly higher than those without stroke. Mitral valve vegetation (OR 1.648; 95% CI 1.113–2.442) and age (OR 1.019; 95% CI 1.007–1.032) were independent risk factors for stroke in IE patients. Stroke increased the risk of hospital deaths (OR 7.673 95%CI 3.634–16.202). Conclusion: Stroke is a common complication of IE. Mitral valve vegetation and old age may incerease the risk of stroke in patients with IE.

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Trends in Infective Endocarditis in California and New York State, 1998-2013

Abstract: In California and New York State, the overall standardized incidence of infective endocarditis was stable from 1998 through 2013, with changes in patient characteristics and etiology over this time.

Cited by 282 publications

References 26 publications

A Systematic Review of the Association between Individual Drugs Injected Intravenously and the Development of Infective Endocarditis

A Systematic Review of the Association between Individual Drugs Injected Intravenously and the Development of Infective Endocarditis

Endocarditis in children and adolescents with congenital heart defects: a Norwegian nationwide register-based cohort study

Stroke in Patients with Infective Endocarditis: A 15-Year Single-Center Cohort Study

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