Trends in Materials for Spine Surgery

Marcolongo, Michele; Sarkar, Sumona; Ganesh, Nandita

doi:10.1016/b978-0-08-055294-1.00208-7

Cited by 5 publications

(6 citation statements)

References 72 publications

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“…If any annular healing occurs after discectomy, it is believed to happen slowly and ultimately results in biomechanically inferior tissue with reduced capacity to accommodate tensile forces [19]. This in turn may trigger reherniation under lower bio mechanical stresses in patients with large postsurgical annular defects, which comprise approximately 30% of those treated with lumbar discectomy [26,27]. Current research in tissue engineering is investigating biomimetic approaches to replicate the lamellar struc ture and induce regeneration [28]; however, the avascular nature of this region and the low technology readiness level of existing research strategies mean that these approaches Spinal fusion aims to reduce pain by restricting the motion of the affected vertebral segment(s), but postoperative biomechanical alterations can result in loss of normal range of motion, reduced shock absorption, instability, and spinal misalignment [15][16][17].…”

Section: The Importance Of Annular Closurementioning

confidence: 99%

“…There have been many excellent reviews describing the necessary biological parameters for annular repair/regeneration [ 27 , 65 , 66 , 67 , 68 ]; suitable biomaterials [ 69 ]; tissue engineered scaffolds [ 64 ]; and the challenges and strategies [ 57 , 70 ] for implementation. Long et al made an important breakthrough by identifying, quantifying, and proposing a testing paradigm for hydrogel-based strategies for AF repair [ 71 ] as shown in Table 1 .…”

Section: Design Requirements For An Annular Closure Devicementioning

confidence: 99%

“… Commercial mechanical annular closure devices. ( Top ) Inclose Surgical Mesh System and the Xclose Tissue Repair System (Anulex Technologies, Inc. Minnetonka, MN, USA) [ 27 ]. ( Middle ) The AnchorKnot ® suture-passing device (Anchor Orthopedics XT Inc., Mississauga, ON, USA [ 31 ].…”

Section: Figurementioning

confidence: 99%

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Lumbar Intervertebral Disc Herniation: Annular Closure Devices and Key Design Requirements

et al. 2022

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Lumbar disc herniation is one of the most common degenerative spinal conditions resulting in lower back pain and sciatica. Surgical treatment options include microdiscectomy, lumbar fusion, total disc replacement, and other minimally invasive approaches. At present, microdiscectomy procedures are the most used technique; however, the annulus fibrosus is left with a defect that without treatment may contribute to high reherniation rates and changes in the biomechanics of the lumbar spine. This paper aims to review current commercially available products that mechanically close the annulus including the AnchorKnot® suture-passing device and the Barricaid® annular closure device. Previous studies and reviews have focused mainly on a biomimetic biomaterials approach and have described some mechanical and biological requirements for an active annular repair/regeneration strategy but are still far away from clinical implementation. Therefore, in this paper we aim to create a design specification for a mechanical annular closure strategy by identifying the most important mechanical and biological design parameters, including consideration of material selection, preclinical testing requirements, and requirements for clinical implementation.

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Section: The Importance Of Annular Closurementioning

confidence: 99%

Section: Design Requirements For An Annular Closure Devicementioning

confidence: 99%

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Lumbar Intervertebral Disc Herniation: Annular Closure Devices and Key Design Requirements

et al. 2022

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“…Several experimental surgeries have been developed. AF sutures strengthen the intensity of AF; thus, they restrict NP from herniating but cannot prevent the progression of IVDD ( Marcolongo et al, 2011 ). Annuloplasty is a minimally invasive method in which heat produced by electricity or radiofrequency radiation strengthens the collagen fibers and seals fissures in a process similar to tissue soldering ( Helm Ii et al, 2017 ).…”

Section: Current Ivdd Treatmentsmentioning

confidence: 99%

Intervertebral Disk Degeneration: The Microenvironment and Tissue Engineering Strategies

Dou

Sun

et al. 2021

Front. Bioeng. Biotechnol.

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Intervertebral disk degeneration (IVDD) is a leading cause of disability. The degeneration is inevitable, and the mechanisms are complex. Current therapeutic strategies mainly focus on the relief of symptoms, not the intrinsic regeneration of the intervertebral disk (IVD). Tissue engineering is a promising strategy for IVDD due to its ability to restore a healthy microenvironment and promote IVD regeneration. This review briefly summarizes the IVD anatomy and composition and then sets out elements of the microenvironment and the interactions. We rationalized different scaffolds based on tissue engineering strategies used recently. To fulfill the complete restoration of a healthy IVD microenvironment, we propose that various tissue engineering strategies should be combined and customized to create personalized therapeutic strategies for each individual.

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“…Table 1. Composition of healthy nucleus pulposus (NP) and annulus fibrosus (AF) and function of these components [26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Spheroid-Based Tissue Engineering Strategies for Regeneration of the Intervertebral Disc

Kasamkattil

Gryadunova

Martin

et al. 2022

IJMS

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Degenerative disc disease, a painful pathology of the intervertebral disc (IVD), often causes disability and reduces quality of life. Although regenerative cell-based strategies have shown promise in clinical trials, none have been widely adopted clinically. Recent developments demonstrated that spheroid-based approaches might help overcome challenges associated with cell-based IVD therapies. Spheroids are three-dimensional multicellular aggregates with architecture that enables the cells to differentiate and synthesize endogenous ECM, promotes cell-ECM interactions, enhances adhesion, and protects cells from harsh conditions. Spheroids could be applied in the IVD both in scaffold-free and scaffold-based configurations, possibly providing advantages over cell suspensions. This review highlights areas of future research in spheroid-based regeneration of nucleus pulposus (NP) and annulus fibrosus (AF). We also discuss cell sources and methods for spheroid fabrication and characterization, mechanisms related to spheroid fusion, as well as enhancement of spheroid performance in the context of the IVD microenvironment.

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Trends in Materials for Spine Surgery

Cited by 5 publications

References 72 publications

Lumbar Intervertebral Disc Herniation: Annular Closure Devices and Key Design Requirements

Lumbar Intervertebral Disc Herniation: Annular Closure Devices and Key Design Requirements

Intervertebral Disk Degeneration: The Microenvironment and Tissue Engineering Strategies

Spheroid-Based Tissue Engineering Strategies for Regeneration of the Intervertebral Disc

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