Trends in Microbiological and Antibiotic Sensitivity Patterns in Infectious Keratitis

Hernández-Camarena, Julio C.; Graue-Hernández, Enrique O; Ortiz-Casas, Mariana; Ramírez-Miranda, Arturo; Navas, Alejandro; Pedro-Aguilar, Lucero; López-Espinosa, Nadia Luz; Gaona-Juárez, Carolina; Bautista-Hernández, Luis Antonio; Lucio, Víctor Manuel Bautista-de

doi:10.1097/ico.0000000000000428

Cited by 96 publications

(95 citation statements)

References 33 publications

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“…Our positive culture rate was 48%, which is consistent with the range reported in the literature of 36–86%[1,4,7,17–19] (Fig 4). Bacterial isolates represented 92% of the total cultures as seen in other series where bacteria account for 88–91% [4,17] of positive cultures.…”

Section: Discussionsupporting

confidence: 91%

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Trends of Bacterial Keratitis Culture Isolates in Jerusalem; a 13- Years Analysis

et al. 2016

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PurposeTo describe the trends in pathogens and antibacterial resistance of corneal culture isolates in infectious keratitis during a period of 13 years at Hadassah-Hebrew University Medical Center.MethodsA Retrospective analysis of bacterial corneal isolates was performed during the months of January 2002 to December 2014 at Hadassah Hebrew University Medical Center. Demographics, microbiological data and antibiotic resistance and sensitivity were collected.ResultsA total of 943 corneal isolates were analyzed during a 13 year period. A total of 415 positive bacterial cultures and 37 positive fungal cultures were recovered, representing 48% of the total cultures. The Annual incidence was 34.78 ± 6.54 cases. The most common isolate was coagulase-negative staphylococcus (32%), which had a significant decrease in trend throughout the study period (APC = -8.1, p = 0.002). Methicillin-resistant Staphylococcus aureus (MRSA) appears to have a decrease trend (APC = -31.2, P = 0.5). There was an increase in the resistance trend of coagulase-negative staphylococci to penicillin (APC = 5.0, P = <0.001). None of the pathogens had developed any resistance to Vancomycin. (P = 0.88).ConclusionsCoagulase negative staphylococci were the predominant bacteria isolated from patients with keratitis. There was no significant change in the annual incidence of cases of bacterial keratitis seen over the past 13 years. Keratitis caused by MRSA appeared to decrease in contrast to the reported literature.

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Section: Discussionsupporting

confidence: 91%

“…Bacterial isolates represented 92% of the total cultures as seen in other series where bacteria account for 88–91% [4,17] of positive cultures.…”

Section: Discussionmentioning

confidence: 90%

Trends of Bacterial Keratitis Culture Isolates in Jerusalem; a 13- Years Analysis

et al. 2016

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“…The prognosis and success rate of infectious keratitis is guided by several factors, which includes the microbial organism virulence, extension of keratitis and associated ocular inflammation. The most common identified organism causing corneal perforations was Staphylococcus epidermidis , which correlates with another study performed in our centre, describing this organism as the most frequently isolated in corneal scrapes 5. Similarly, a group from India described S epidermidis as the most common organism found in perforated ulcers 11.…”

Section: Discussionsupporting

confidence: 83%

“…For all cases, treatment was decided by a cornea specialist. Additional treatment was given according to the specific aetiology; patients with infectious keratitis were studied with corneal scrapes and sent for culture as described elsewhere,5 and treated initially with a broad-spectrum antibiotic, antiviral or antifungal agents administered according to each specific case, and treatment was adjusted according to the antibiogram if available. When a recurrence of infection was evident, new cultures were done and specific treatment was given for each case accordingly.…”

Section: Methodsmentioning

confidence: 99%

Non-traumatic corneal perforations: aetiology, treatment and outcomes

Loya-García¹,

Serna‐Ojeda²,

Pedro-Aguilar³

et al. 2016

Br J Ophthalmol

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“…Although usually effective in eliminating the infectious agent, the incidence of resistance of infectious agents to antibiotics and antivirals is increasing. (2, 3) In conditions such as fungal and Acanthamoeba infections, topical medications are not very effective and mixed bacterial and fungal infections probably have the worst outcomes of all. (4) Another problem is the fact that antimicrobial agents, and the preservatives in the topical medications, are toxic and can prevent corneal healing.…”

Section: Introductionmentioning

confidence: 99%

Surgical management of corneal infections

Tuli

Gray

2016

Current Opinion in Ophthalmology

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Purpose of review The purpose of this review is to discuss the options for, and recent developments in, the surgical treatment of corneal infections. While the mainstay of treatment of corneal infections is topical antimicrobial agents, surgical intervention may be necessary in a number of cases. These include advanced disease at presentation, resistant infections, and progressive ulceration despite appropriate treatment. Prompt and appropriate treatment can make the difference between a good outcome and loss of vision or the eye. Recent findings There are a number of surgical therapies available for corneal infections. Preferred therapeutic modalities differ based on the size, causation, and location of the infection but consist of either replacement of the infected tissue or structural support of the tissue to allow healing. While there are no completely novel therapies that have been developed recently, there have been incremental improvements in the existing treatment modalities making them more effective, easier, and safer. Summary Several options are available for surgically managing corneal infections. Ophthalmologists should select the optimal procedure based on the individual patient’s situation.

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Trends in Microbiological and Antibiotic Sensitivity Patterns in Infectious Keratitis

Abstract: There was a nonsignificant increase in the recovered gram-positive and gram-negative microorganisms over time. We observed an increased resistance to methicillin in almost half of the MRSA and MRCNS isolates.

Cited by 96 publications

References 33 publications

Trends of Bacterial Keratitis Culture Isolates in Jerusalem; a 13- Years Analysis

Trends of Bacterial Keratitis Culture Isolates in Jerusalem; a 13- Years Analysis

Non-traumatic corneal perforations: aetiology, treatment and outcomes

Surgical management of corneal infections

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