Trends in nanotechnology-based delivery systems for dermal targeting of drugs: an enticing approach to offset psoriasis

Saleem, Sadaf; Iqubal, Mohammad Kashif; Garg, Sanjay; Ali, Javed; Baboota, Sanjula

doi:10.1080/17425247.2020.1758665

Cited by 51 publications

(26 citation statements)

References 126 publications

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“…The skin lesions, covered with white and silver scales, are the result of (a) dysregulated proliferation of keratinocytes, (b) limited epidermal turnover time, (c) proliferation of new dermal blood vessels, and (d) infiltration of multiple inflammatory cells. The vicious cycle is sustained by the keratinocytes-mediated stimulation of proinflammatory chemokines and cytokines, which ultimately impair the barrier function of the epidermal layer and cause its thickening [ 192 ]. In the past decades, various pathogenic mechanisms have been identified, leading to different therapeutic approaches with improved patient compliance and limited adverse effects.…”

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

“…Therefore, multiple and frequent applications are needed to obtain a therapeutic effect, thus causing possible skin irritation. To overcome these limitations and improve the patient response, advanced nano-formulations (such as solid lipid nanoparticles, nanostructured lipid particles, polymeric nanoparticles, and nano-emulsions) have been explored as psoriasis drug delivery systems [ 191 , 192 ]. Nanocarriers with optimized size, shape, surface charge, and functionalities (hyaluronic acid, heparin sulfate, or chondroitin sulfate with affinity towards skin receptors) have shown an enhanced permeation through the stratum corneum by loosening the tight junctions between the epithelial cells and delivering their bioactive molecules into the skin deeper layers.…”

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

“…Nanocarriers with optimized size, shape, surface charge, and functionalities (hyaluronic acid, heparin sulfate, or chondroitin sulfate with affinity towards skin receptors) have shown an enhanced permeation through the stratum corneum by loosening the tight junctions between the epithelial cells and delivering their bioactive molecules into the skin deeper layers. Based on a more efficient targeting ability and permeation enhancement, innovative nanotechnology-based delivery systems hold great potential in psoriasis therapy, improving the benefits–risks ratio [ 192 ]. Examples of these approaches will be discussed in detail in Section 4 of this review.…”

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

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Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

et al. 2021

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Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, and physiological conditions, such as late-stage diabetes, dermatitis, or psoriasis. These events are locally characterized by an intense inflammatory response, a high generation of harmful free radicals, or an impairment in the immune response regulation, which can profoundly change the skin tissue’ repair process, vulnerability, and functionality. Moreover, diabetes diffusion, antibiotic resistance, and abuse of aggressive soaps and disinfectants following the COVID-19 emergency could be causes for the future spreading of skin disorders. In the last years, hydroxycinnamic acids and derivatives have been investigated and applied in several research fields for their anti-oxidant, anti-inflammatory, and anti-bacterial activities. First, in this study, we give an overview of these natural molecules’ current source and applications. Afterwards, we review their potential role as valid alternatives to the current therapies, supporting the management and rebalancing of skin disorders and diseases at different levels. Also, we will introduce the recent advances in the design of biomaterials loaded with these phenolic compounds, specifically suitable for skin disorders treatments. Lastly, we will suggest future perspectives for introducing hydroxycinnamic acids and derivatives in treating skin disorders.

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Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

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Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

et al. 2021

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“…This formulation was evaluated in a mouse model of imiquimod-induced psoriatic plaque and resulted in the reversal of psoriasis symptoms [ 38 ]. Some of these innovations have also been reviewed earlier by several groups [ 17 , 126 , 127 , 128 ], and an extended overview is presented in Table 2 . Promising results are obtained with a combination therapy of liposomal drug release using laser irradiation, where no recurrence of symptoms was observed in treated mice [ 129 ].…”

Section: Application In Inflammatory Diseasementioning

confidence: 99%

Recent Advances in Liposomal-Based Anti-Inflammatory Therapy

et al. 2021

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Liposomes can be seen as ideal carriers for anti-inflammatory drugs as their ability to (passively) target sites of inflammation and release their content to inflammatory target cells enables them to increase local efficacy with only limited systemic exposure and adverse effects. Nonetheless, few liposomal formulations seem to reach the clinic. The current review provides an overview of the more recent innovations in liposomal treatment of rheumatoid arthritis, psoriasis, vascular inflammation, and transplantation. Cutting edge developments include the liposomal delivery of gene and RNA therapeutics and the use of hybrid systems where several liposomal bilayer features, or several drugs, are combined in a single formulation. The majority of the articles reviewed here focus on preclinical animal studies where proof-of-principle of an improved efficacy–safety ratio is observed when using liposomal formulations. A few clinical studies are included as well, which brings us to a discussion about the challenges of clinical translation of liposomal nanomedicines in the field of inflammatory diseases.

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“…Among the hydrogels used as wound dressings and topical drug carriers, collagen proteins are the most common as they not only are a biocompatible and biodegradable component of the human extracellular matrix (ECM) but also actively participate in the wound healing process [ 52 , 53 ]. Their excellent hydrophilicity makes them a suitable candidate for patches with applications in psoriasis, as an adequate amount of water is essential for the successful penetration of drugs during topical delivery [ 54 ]. Their biological instability makes their modification, usually by cross-linking, a necessity [ 55 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Collagen-Based Patches as Curcumin Carriers

Terzopoulou

Michopoulou²,

Palamidi

et al. 2020

Polymers

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Patients with psoriasis are dissatisfied with the standard pharmacological treatments, whether systemic or topical, with many of them showing interest in complementary and alternative medicine. Curcumin (Cur), a natural polyphenol derived from turmeric, has recently gained attention for skin-related diseases because of its proven anti-inflammatory action. However, topical treatment with Cur would be inadequate because of its hydrophobicity, instability, and low bioavailability. In addition, hyperkeratosis and lack of moisture in psoriatic skin result in low penetration that would prevent actives from permeating the stratum corneum. In this work, a polymer-based formulation of Cur for the topical treatment of psoriasis is reported. To improve the physicochemical stability of Cur, it was first encapsulated in chitosan nanoparticles. The Cur-loaded nanoparticles were incorporated in a hydrophilic, biocompatible collagen-based patch. The nanoparticle-containing porous collagen patches were then chemically cross-linked. Morphology, chemical interactions, swelling ratio, enzymatic hydrolysis, and Cur release from the patches were evaluated. All patches showed excellent swelling ratio, up to ~1500%, and after cross-linking, the pore size decreased, and their hydrolysis rates decelerated. The in vitro release of Cur was sustained with an initial burst release, reaching 55% after 24 h. Cur within the scaffolds imparted a proliferation inhibitory effect on psoriatic human keratinocytes in vitro.

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Trends in nanotechnology-based delivery systems for dermal targeting of drugs: an enticing approach to offset psoriasis

Cited by 51 publications

References 126 publications

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

Recent Advances in Liposomal-Based Anti-Inflammatory Therapy

Preparation and Evaluation of Collagen-Based Patches as Curcumin Carriers

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