Trends in the environmental risks associated with earlier onset in multiple sclerosis

Huang, Jesse; Kockum, Ingrid; Stridh, Pernilla

doi:10.1016/j.msard.2022.104250

Cited by 7 publications

(8 citation statements)

References 115 publications

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“…To facilitate similar analyses, we provide a supplementary Microsoft Excel-based tool where users can assess phenotype and genotype-derived data in a 96-well plate format (Samples Verification and Quality Control Tool, SVAQC; Huang et al, 2021). Data suspected of containing misidentified samples can be analyzed and corrected for a wide range of common sample and data handling mistakes.…”

Section: Systematic Approaches For Identifying Sample/data Mishandlingmentioning

confidence: 99%

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Recovering Misidentified Samples Through Genetic Discordance Clustering

Huang,

Kockum,

Stridh

2024

Current Protocols

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The many logistical and technical challenges associated with sample and data handling in largescale genotyping studies can increase the risk of sample misidentification, which may compromise subsequent analyses. However, the standard quality assurance methods typical for large genotyping arrays can often be further utilized to identify and recover problematic samples. This article emphasizes the importance of identifying and correcting underlying sample misidentification rather than simply excluding known discrepancies, which may potentially include undetected issues. Lastly, we provide a screening protocol to complement standard quality assessments as a guideline for identifying mismatched samples and a tool for assessing the most common causes of sample misidentification. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC.

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Section: Systematic Approaches For Identifying Sample/data Mishandlingmentioning

confidence: 99%

“…The referenced tool has been made publicly available through a repository (https:// doi. org/ 10.17605/ OSF.IO/ 5KPUC; Huang et al, 2021).…”

Section: Conflict Of Interestmentioning

confidence: 99%

Recovering Misidentified Samples Through Genetic Discordance Clustering

Huang,

Kockum,

Stridh

2024

Current Protocols

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“…MS is also triggered by environmental risk factors, including smoking, reduced exposure to sunlight, and infection with the Epstein–Barr virus [ 52 ]. For example, tobacco smoking is generally associated with an increased risk of MS in a dose-dependent manner [ 52 ], probably due to the gene-environment interaction "smoking and HLA-related MS susceptibility" [ 53 ], depending on lung irritation due to smoke inhalation and the triggering of T cells in the lungs [ 54 ]. Moreover, smoking is probably related to a worse diagnosis and a faster progression of the disease [ 52 ].…”

Section: Multiple Sclerosis and Gut Microbiotamentioning

confidence: 99%

“…For example, tobacco smoking is generally associated with an increased risk of MS in a dose-dependent manner [ 52 ], probably due to the gene-environment interaction "smoking and HLA-related MS susceptibility" [ 53 ], depending on lung irritation due to smoke inhalation and the triggering of T cells in the lungs [ 54 ]. Moreover, smoking is probably related to a worse diagnosis and a faster progression of the disease [ 52 ]. Another important environmental factor is low sun exposure, which causes a deficiency in vitamin D [ 55 ], probably due to the role of this vitamin in the regulation of inflammatory phenomena in auto-immune diseases [ 56 ].…”

Section: Multiple Sclerosis and Gut Microbiotamentioning

confidence: 99%

Gut-Microbiota, and Multiple Sclerosis: Background, Evidence, and Perspectives

et al. 2023

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Many scientific studies reveal a significant connection between human intestinal microbiota, eating habits, and the development of chronic-degenerative diseases; therefore, alterations in the composition and function of the microbiota may be accompanied by different chronic inflammatory mechanisms. Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), in which autoreactive immune cells attack the myelin sheaths of the neurons. The purpose of this paper was to describe the main changes that occur in the gut microbiota of MS patients, with a focus on both microbiota and its implications for health and disease, as well as the variables that influence it. Another point stressed by this paper is the role of microbiota as a triggering factor to modulate the responses of the innate and adaptive immune systems, both in the intestine and in the brain. In addition, a comprehensive overview of the taxa modified by the disease is presented, with some points on microbiota modulation as a therapeutic approach for MS. Finally, the significance of gastro-intestinal pains (indirectly related to dysbiosis) was assessed using a case study (questionnaire for MS patients), as was the willingness of MS patients to modulate gut microbiota with probiotics.

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“…MS onset has been recognized as a multifaceted interplay of genetic, environmental, and lifestyle risk factors [ 120 ]. The environmental and lifestyle risk factors for MS onset include cigarette smoking [ 121 ], youth obesity [ 122 ], and Epstein–Barr virus infection [ 123 ].…”

Section: Chitinases and Multiple Sclerosis (Ms)mentioning

confidence: 99%

Chitinase Signature in the Plasticity of Neurodegenerative Diseases

Russo

Valle

Casabona

et al. 2023

IJMS

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Several reports have pointed out that Chitinases are expressed and secreted by various cell types of central nervous system (CNS), including activated microglia and astrocytes. These cells play a key role in neuroinflammation and in the pathogenesis of many neurodegenerative disorders. Increased levels of Chitinases, in particular Chitotriosidase (CHIT-1) and chitinase-3-like protein 1 (CHI3L1), have been found increased in several neurodegenerative disorders. Although having important biological roles in inflammation, to date, the molecular mechanisms of Chitinase involvement in the pathogenesis of neurodegenerative disorders is not well-elucidated. Several studies showed that some Chitinases could be assumed as markers for diagnosis, prognosis, activity, and severity of a disease and therefore can be helpful in the choice of treatment. However, some studies showed controversial results. This review will discuss the potential of Chitinases in the pathogenesis of some neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and multiple sclerosis, to understand their role as distinctive biomarkers of neuronal cell activity during neuroinflammatory processes. Knowledge of the role of Chitinases in neuronal cell activation could allow for the development of new methodologies for downregulating neuroinflammation and consequently for diminishing negative neurological disease outcomes.

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Trends in the environmental risks associated with earlier onset in multiple sclerosis

Cited by 7 publications

References 115 publications

Recovering Misidentified Samples Through Genetic Discordance Clustering

Recovering Misidentified Samples Through Genetic Discordance Clustering

Gut-Microbiota, and Multiple Sclerosis: Background, Evidence, and Perspectives

Chitinase Signature in the Plasticity of Neurodegenerative Diseases

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