Trends in the Presentation and Treatment of Basal Cell Carcinomas

Roenigk, Randall K.; Rátz, F.; Bailin, Philip L.; Wheeland, F.A.C.P. Ronald G.

doi:10.1111/j.1524-4725.1986.tb01993.x

Cited by 188 publications

(133 citation statements)

References 15 publications

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“…In our study, the failure rate after surgery was very low (0.7% at 4 years), lower than the published failure rates after surgical resection which range from 2% to 10% (Marchac and Duport, 1980;Dubin and Kopf, 1983;Roenigk et al, 1986;Marchac, 1988;Ashby et al, 1989;Rowe et al, 1989;Silverman et al, 1992a;Bonvallot et al, 1993;Lawrence, 1993). It is closer to that obtained with Mohs surgery, which is often below 2% (Tromovitch and Stegman, 1978;Robins, 1981;Robins et al, 1985;Roenigk et al, 1986;Rowe et al, 1989;Lawrence, 1993;Hruza, 1994).…”

Section: Failure Ratecontrasting

confidence: 69%

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Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study

Avril

Aupérin²,

Margulis³

et al. 1997

Br J Cancer

297

175

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Summary Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of the face measuring less than 4 cm. The primary end point was the failure rate (persistent or recurrent disease) after 4 years of follow-up. The secondary end point was the cosmetic results assessed by the patient, the dermatologist and three persons not involved in the trial. In the course of the trial, 347 patients were treated. Of the 174 patients in the surgery group, 71% had local anaesthesia and 91% frozen section examination. Of the 173 patients in the radiotherapy group, 55% were treated with interstitial brachytherapy, 33% with contactherapy and 12% with conventional radiotherapy. The 4-year actuarial failure rate (95% Cl) was 0.7% (0.1-3.9%) in the surgery group compared with 7.5% (4.2-13.1%) in the radiotherapy group (log-rank P= 0.003). The cosmetic results assessed by four of the five judges were significantly better after surgery than after radiotherapy. Eighty-seven per cent of the surgery-treated patients and 69% of the radiation-treated patients considered the cosmetic result as good (P < 0.01). Thus, in the treatment of BCC of the face of less than 4 cm in diameter, surgery should be preferred to radiotherapy.

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Section: Failure Ratecontrasting

confidence: 69%

“…It is closer to that obtained with Mohs surgery, which is often below 2% (Tromovitch and Stegman, 1978;Robins, 1981;Robins et al, 1985;Roenigk et al, 1986;Rowe et al, 1989;Lawrence, 1993;Hruza, 1994). In contrast to radiotherapy, a histological appraisal of the efficiency of the treatment is possible with surgery.…”

Section: Failure Ratesupporting

confidence: 54%

Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study

Avril

Aupérin²,

Margulis³

et al. 1997

Br J Cancer

297

175

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“…BCC in the periocular area has a high recurrence rate (Roenigk et al 1986). Previously treated lesions carry a higher recurrence rate than primary tumours.…”

Section: Discussionmentioning

confidence: 99%

Mohs' micrographic surgery for basal cell carcinomas on the eyelids and medial canthal area. II. Reconstruction and follow‐up

Lindgren¹,

Lindblom²,

Larkö

2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To report our experience of reconstruction and follow-up of eyelid basal cell carcinomas treated with Mohs' micrographic technique. Methods: Sixty-four periocular basal cell carcinomas, with a high risk of recurrence in one or more aspects with regard to location, size, morphology or prior treatment, were excised using Mohs' micrographic technique. All ensuing defects were repaired. The cases were followed prospectively for up to ten years. All complications and interventions were documented during the follow-up period. Results: The average size of the defect before repair was 21 mm (range 5-45 mm). The mean follow-up time was 49 months (range 3-120). The recurrence rate was 5% (3 of 64 cases). The three recurrences occurred after one, four and six years, respectively. Conclusions: The recurrence rate of high risk tumours reported in this study was less than reported with other modes of treatment and comparable with that in other studies using Mohs' micrographic technique.

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“…4 The tumor is seen especially in people of white ethnicity. 5 Its prevalence is related to increasing age 6 and frequent exposure to UV light, 7,8 and most of the BCCs develop on facial 9,10 areas, where substantial disfigurement can result. Basal cell carcinomas occurring in younger persons 11 and those with immunodeficiency syndromes 12,13 usually are more aggressive.…”

mentioning

confidence: 99%