Trends in the prevalence of chronic kidney disease, other chronic diseases and health-related behaviors in an adult Korean population: data from the Korean National Health and Nutrition Examination Survey (KNHANES)

Lee, Seong Woo; Kim, Yong Chul; Oh, Se Won; Koo, Hyeon‐Kyoung; Na, Ki Young; Chae, Dong Wan; Kim, Sejoong; Chin, Ho Jun

doi:10.1093/ndt/gfr154

Cited by 39 publications

(35 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the risk of CKD is higher in women than men (OR, 1.354; p < 0.001), and the difference seems to be caused by the susceptibility to albuminuria (OR, 1.416; p < 0.001) rather than decreased GFR (OR, 1.057; p = 0.683). When GFR was estimated using the MDRD Study equation, the increased risks of GFR < 60 mL/min/1.73 m 2 in women were observed in previous studies: OR, 3.16 ( p < 0.001) using KNHANES III and IV-1 [12]; frequencies of 3.4%, 9.7%, 10.2%, and 4.6% in women, and 1.0%, 5.4%, 3.1%, and 2.6% were seen in men through KNHANES I-IV [13]. There seemed to be no difference in ACR according to gender in the previous study (10.1% and 10.3% in women and men, respectively) [11].…”

Section: Discussionmentioning

confidence: 83%

“…The previously reported CKD prevalence calculated from the MDRD Study equation together with ACR was 13.7% in urban Korean volunteers aged ≥ 35 [11]. The CKD prevalence calculated from the MDRD Study equation alone was 8.8% in 2005 and 7.2% in 2007 in Korea National Health and Nutrition Examination Survey (KNHANES) subjects aged ≥ 20 [12]; the prevalence calculated using the MDRD Study equation with the dipstick proteinuria method has tended to decrease since 2001 in men and since 2005 in women among KNHANES I to IV (1998 to 2009) subjects aged ≥ 20 [13]. Since there are no reports on CKD prevalence using the CKD-EPI equations to estimate GFR and ACR to measure albuminuria for Koreans, a new analysis of CKD prevalence is necessary.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population

Kim

2016

Korean J Intern Med

View full text Add to dashboard Cite

Background/AimsAn updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was performed to estimate the prevalence of CKD in the Korean adult population as defined and classified by the KDIGO guidelines.MethodsCross-sectional samples of the fifth Korean National Health and Nutrition Examination Survey for 2011 to 2012 were examined for adults aged ≥ 19 years. CKD prevalence was determined based on decreased GFR and albuminuria. The GFR was estimated using the CKD Epidemiology Collaboration creatinine equation, and albuminuria was evaluated using the albumin-to-creatinine ratio (ACR) in spot urine.ResultsOf the 16,576 subjects participating in the survey, 10,636 (4,758 men, 5,878 women) were included in the present study. The prevalence of CKD was estimated as 7.9% (7.8% in 2011 and 8.0% in 2012, p = 0.770). The prevalence of low, moderately increased, high, and very high CKD risk prognosis was 92.0%, 6.3%, 1.1%, and 0.6%, respectively. The prevalence of albuminuria (ACR ≥ 30 mg/g) in individuals with GFR ≥ 60 mL/min/1.73 m2 has reached 5.7%. The odds ratios of hypertension and diabetes to CKD were 3.4 and 3.1 in men, and 2.9 and 2.0 in women (all p < 0.001), respectively.ConclusionsA large percentage of CKD patients had albuminuria prior to a decrease in GFR. Regular laboratory tests for albuminuria for the high-risk group, and especially for hypertensive or diabetic patients, might improve detection of CKD at an early stage.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population

Kim

2016

Korean J Intern Med

View full text Add to dashboard Cite

show abstract

“…According to the present study conducted in Korea, the prevalence of CKD in subjects with diabetes was 8.6%, lower than in Western populations as well as other East Asian populations [29]. In the United States, the prevalence of CKD increased from 14.9% in NHANES 1988-1994 to 17.7% in NHANES 2005-2008 in patients with diabetes [30].…”

Section: Discussionmentioning

confidence: 92%

Prevalence and Determinants of Diabetic Nephropathy in Korea: Korea National Health and Nutrition Examination Survey

Ahn

et al. 2014

Diabetes Metab J

View full text Add to dashboard Cite

BackgroundDiabetic nephropathy is a leading cause of end stage renal disease and is associated with an increased risk of cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), and the prevalence of diabetic nephropathy varies with ethnicity. The prevalence of diabetic nephropathy and its determinants in Korean adults have not previously been studied at the national level. This cross-sectional study was undertaken to ascertain the prevalence and determinants of albuminuria and chronic kidney disease (CKD) in Korean patients with diabetes.MethodsThe Korea National Health and Nutrition Examination Survey (KNHANES) V, conducted in 2011, was used to define albuminuria (n=4,652), and the dataset of KNHANES IV-V (2008-2011) was used to define CKD (n=21,521). Selected samples were weighted to represent the entire civilian population in Korea. Albuminuria was defined as a spot urine albumin/creatinine ratio >30 mg/g. CKD was defined as a GFR <60 mL/min/1.73 m2.ResultsAmong subjects with diabetes, 26.7% had albuminuria, and 8.6% had CKD. Diabetes was associated with an approximate 2.5-fold increased risk of albuminuria, with virtually no difference between new-onset and previously diagnosed diabetes. Only systolic blood pressure was significantly associated with albuminuria, and old age, high serum triglyceride levels, and previous cardiovascular disease (CVD) were related with CKD in subjects with diabetes.ConclusionKorean subjects with diabetes had a higher prevalence of albuminuria and CKD than those without diabetes. Blood pressure was associated with albuminuria, and age, triglyceride level, and previous CVD were independent determinants of CKD in subjects with diabetes.

show abstract

“…The CKD prevalence in Korean adults was 7.2% in 2007 according to the Korean National Health and Nutrition Examination Survey (2). In clinical trials that have examined whether angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) slow CKD progression, both treatments were found to be effective in terms of serum creatinine (SCr) preservation, progression to ESRD, or death (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

A Randomized, Controlled Trial of Oral Intestinal Sorbent AST-120 on Renal Function Deterioration in Patients with Advanced Renal Dysfunction

Hui¹,

Kang²,

Park³

et al. 2016

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background and objectives The notion that oral intestinal sorbent AST-120 slows renal disease progression has not been evaluated thoroughly. In this study, we investigated the long-term effect of AST-120 on renal disease progression (doubling of serum creatinine, eGFR decrease .50%, or initiation of RRT) in patients with advanced CKD.Design, setting, participants, & measurements We prospectively recruited 579 patients (CKD stage 3 or 4) from 11 medical centers in Korea from March 4, 2009 to August 31, 2010 and randomized them into an AST-120 arm and a control arm. Patients in the AST-120 arm were given 6 g AST-120 in three divided doses per day, and those in the control arm received only standard conventional treatment (open-label design) for 36 months or until the occurrence of primary outcomes.Results Levels of serum and urine indoxyl sulfate and b2-microglobulin decreased throughout the study period in both treatment arms; however, there was not a significant difference in change in uremic toxins in the AST-120 and control arms. The two arms were not different in the occurrence of composite primary outcomes (100 events in 272 individuals in the AST-120 arm and 100 events in 266 individuals in the control arm; hazard ratio, 1.12; 95% confidence interval, 0.85 to 1.48; log-rank P=0.45). The decline in eGFR and change in proteinuria were similar in the two treatment arms over time (P randomization-time =0.64 and P randomization-time =0.16, respectively). There was no difference in mortality (nine deaths in the AST-120 arm and 11 deaths in the control arm; log-rank P=0.73) or unplanned hospitalizations (102 in the AST-120 arm and 109 in the control arm; log-rank P=0.76) in the two treatment arms. There was no significant difference of the health-related quality of life score between the two arms.Conclusions Long-term use of AST-120 added to standard treatment did not change renal disease progression, proteinuria, mortality, and health-related quality of life in patients with advanced renal dysfunction.

show abstract

Trends in the prevalence of chronic kidney disease, other chronic diseases and health-related behaviors in an adult Korean population: data from the Korean National Health and Nutrition Examination Survey (KNHANES)

Cited by 39 publications

References 35 publications

Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population

Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population

Prevalence and Determinants of Diabetic Nephropathy in Korea: Korea National Health and Nutrition Examination Survey

A Randomized, Controlled Trial of Oral Intestinal Sorbent AST-120 on Renal Function Deterioration in Patients with Advanced Renal Dysfunction

Contact Info

Product

Resources

About