Triboelectrification and dissolution property enhancements of solid dispersions

Asare-Addo, Kofi; Šupuk, Enes; Al-Hamidi, Hiba; Owusu-Ware, Samuel K.; Nokhodchi, Ali; Conway, Barbara R.

doi:10.1016/j.ijpharm.2015.03.013

Cited by 27 publications

(23 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Triboelectrification has been used to study the impact of the counter ion on flurbiprofen salts as a consideration during the preformulation process [22], reduce the charging of flurbiprofen (a drug with a high propensity for charging) in binary mixtures of cellulose ethers [23], ordered mixing [24] and recently as a way of manipulating the charge of their final product of solid dispersions using single solvents and binary mixtures of solvents [25].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…The pure CBZ, GLU and their co-ground samples were characterised also using FT-IR according to the methodology detailed by Asare-Addo et al [25]. In brief, a 5-10 mg sample of pure CBZ, pure GLU, Physical mix of CBZ and GLU, CBZ and GLU ground for either 10 min or 60 min (all at a 1:1 ratio) were placed on an attenuated total reflection (ATR) plate and analysed using FTIR spectroscopy (Nicolet 380 FT-IR spectrometer, ThermoElectron Corporation, USA).…”

Section: Fourier Transform Infrared (Ft-ir)mentioning

confidence: 99%

See 1 more Smart Citation

An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine

et al. 2016

Self Cite

View full text Add to dashboard Cite

An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine, Powder Technology (2016Technology ( ), doi: 10.1016Technology ( /j.powtec.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T AbstractOne of strategies adopted to improve the dissolution rates of poorly soluble drugs is by co-grinding the drug with a hydrophilic carrier. However, the introduction of mechanical forces during th e grinding process can lead to changes in the physicochemical characteristics as well as an increase in the surface free energy of the ground particles, which causes an alteration in the electrostatic properties of these particles. The solid state characteristics of glucosamine hydrochloride (GLU) and carbamazepine (CBZ) and their co-ground mixtures were studied using DSC, XRPD and SEM.These revealed that polymorphic transformations occurred due to the grinding process. The influence of grinding time on the triboelectrification properties of the formulations was also studied.Both pure CBZ and GLU powders were predominantly electro-positively charged and their charging properties increased with increasing grinding time. CBZ:GLU physical mixtures exhibited complicated bipolar charging behaviour, however, when subjected to grinding, these mixtures demonstrated mainly electronegative charge properties. The influence of both grinding time and CBZ content within CBZ:GLU mixtures were examined. The value of net-electronegative-charge density of CBZ:GLU mixtures was shown to increase with grinding time and /or when increasing the percentage proportion of CBZ up to 30 % w:w. This study helps to provide information about the handling of these formulation and gives a formulator tools to ascertain appropriate ratios for handling and possible simultaneous dissolution improvements.

show abstract

Section: Accepted M Manuscriptmentioning

confidence: 99%

Section: Fourier Transform Infrared (Ft-ir)mentioning

confidence: 99%

An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…The poor solubility of drugs has always been a major problem in pharmaceutical development and this problem is now more prevalent with more than 40 % of the new chemical entities being practically insoluble in water or lipophilic in nature [3][4][5][6][7]. As dissolution rates are typically the rate-limiting step for bioavailability, especially for poorly soluble drugs, enhancement of solubility is vital to attaining suitable systemic concentrations for therapeutic effect [8].…”

Section: Introductionmentioning

confidence: 99%

“…Several authors have classed the solid dispersion approach as one of the most effective method of improving dissolution of drugs [5,8,22]. It involves the dispersion of one or more active ingredients in an inert excipient or carrier, where the active ingredients could exist in a finely crystalline, solubilised or amorphous state [23,24].…”

Section: Introductionmentioning

confidence: 99%

“…Al-Hamidi and co-workers have studied the rate of carbamazepine (CBZ), ibuprofen (IBU) and PXM (PXM) in solvent evaporated and co-ground solid dispersions [3,22,28,29]. Asare-Addo et al [8], also studied the effect of GLU on indomethacin (IND) dissolution and charging properties using a solvent evaporation process. All these authors showed that incorporation of GLU in PXM, IBU, CBZ and IND using either the solvent evaporation or grinding method significantly increased the dissolution rates of these drugs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

Adebisi

Kaialy

Hussain

et al. 2016

Colloids and Surfaces B: Biointerfaces

Self Cite

View full text Add to dashboard Cite

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions, Colloids and Surfaces B: Biointerfaces http://dx.doi.org/10. 1016/j.colsurfb.2016.07.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 4. GLU improved the handling of PXM as it significantly reduced its charge in all the spray dried formulations. Technique could be used to determine appropriate formulations that improve handling AbstractThis work explores the use of both spray drying and D-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging was also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no enhancement in solubility relative to that of the parent PXM.XRPD results also showed the spray drying process to decrease the crystallinity of GLU and solid dispersions produced. The presence of GLU improved the dissolution rate of PXM. Spray dried PXM: GLU at a ratio of 2:1 had the most improved dissolution. The spray drying process generally yielded PXM-GLU spherical particles of around 2.5 µm which may have contributed to the improved dissolution. PXM showed a higher tendency for charging in comparison to the carrier GLU (-3.8 versus 0.5 nC/g for untreated material and -7.5 versus 3.1 nC/g for spray dried materials). Spray dried PXM and spray dried GLU demonstrated higher charge densities than untreated PXM and untreated GLU, respectively. Regardless of PXM:GLU ratio, all spray dried PXM:GLU solid dispersions showed a negligible charge density (net-CMR: 0.1 -0.3 3 nC/g). Spray drying of PXM:GLU solid dispersions can be used to produce formulation powders with practically no charge and thereby improving handling as well as dissolution behaviour of PXM.

show abstract

Mitigation of Tribocharging in Pharmaceutical Powders using Surface Modified V-Blenders

Mehta,

Mukherjee,

Shah

et al. 2023

Pharm Res

View full text Add to dashboard Cite

Triboelectrification and dissolution property enhancements of solid dispersions

Cited by 27 publications

References 47 publications

An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine

An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

Mitigation of Tribocharging in Pharmaceutical Powders using Surface Modified V-Blenders

Contact Info

Product

Resources

About