Tribulus terrestris L. protects glomerular endothelial cells via the miR155-H2AC6 interaction network in hypertensive renal injury

Pei, Hui-Juan; Yang, Jie; Hu, Fang-Xiao; Chen, Yongzhi; Yang, Chuanhua

doi:10.21037/atm-21-5641

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…H2AC6, which belongs to the H2A family of histones, is a replication-dependent histone. Histone H2A has been linked to diabetic nephropathy, atherosclerosis, cardiovascular disease, and hypertensive kidney injury ( Gao et al, 2013 ; Jiang et al, 2018 ; Yerra and Advani, 2018 ; Pei et al, 2021 ). MLKL may serve as a promising target to block tumor regeneration and participate in the regulation of necroptosis pathway, thereby improving the efficacy of radiation therapy for colorectal cancer ( Wang et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Development of necroptosis-related gene signature to predict the prognosis of colon adenocarcinoma

Zhang²,

Chen³

2022

Front. Genet.

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Colon adenocarcinoma (COAD) is a common malignancy and has a high mortality rate. However, the current tumor node metastasis (TNM) staging system is inadequate for prognostic assessment of COAD patients. Therefore, there is an urgent need to identify reliable biomarkers for the prognosis COAD patients. The aberrant expression of necroptosis-related genes (NRGs) is reported to be associated with tumorigenesis and metastasis. In the present work, we compared the expression profiles of NRGs between COAD patients and normal individuals. Based on seven differentially expressed NRGs, a risk score was defined to predict the prognosis of COAD patients. The validation results from both training and independent external cohorts demonstrated that the risk score is able to distinguish the high and low risk COAD patients with higher accuracies, and is independent of the other clinical factors. To facilitate its clinical use, by integrating the proposed risk score, a nomogram was built to predict the risk of individual COAD patients. The C-index of the nomogram is 0.75, indicating the reliability of the nomogram in predicting survival rates. Furthermore, two candidate drugs, namely dapsone and xanthohumol, were screed out and validated by molecular docking, which hold the potential for the treatment of COAD. These results will provide novel clues for the diagnosis and treatment of COAD.

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Section: Discussionmentioning

confidence: 99%

Development of necroptosis-related gene signature to predict the prognosis of colon adenocarcinoma

Zhang²,

Chen³

2022

Front. Genet.

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“…Based on TCM theory, Tribulus terrestris L. (TT), a common herb and first documented in Shen-Nong-Ben-Cao-Jing, is able to calm liver and dispel melancholy (“Ping Gan Jie Yu in Chinese), promote blood circulation to dissipate wind (“Huo Xue Qu Feng” in Chinese), improve eyesight (“Ming Mu” in Chinese) and relieve itching (“Zhi Yang” in Chinese). Previous studies demonstrated the effects of TT on prostate health [ 8 ], reproductive processes [ 9 ], hypertensive renal injury [ 10 ], inflammation, ovarian cells apoptosis and so on [ 11 ]. But the study on anti-liver cancer of TT was hardly reported.…”

Section: Introductionmentioning

confidence: 99%

Promoting liver cancer cell apoptosis effect of Tribulus terrestris L. via reducing sphingosine level was confirmed by network pharmacology with metabolomics

Zhao

Zhang

et al. 2023

Heliyon

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Tribulus terrestris L. protects glomerular endothelial cells via the miR155-H2AC6 interaction network in hypertensive renal injury

Cited by 2 publications

References 49 publications

Development of necroptosis-related gene signature to predict the prognosis of colon adenocarcinoma

Development of necroptosis-related gene signature to predict the prognosis of colon adenocarcinoma

Promoting liver cancer cell apoptosis effect of Tribulus terrestris L. via reducing sphingosine level was confirmed by network pharmacology with metabolomics

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