Tributyltin changes the thyroid gland morphology of male rats

Pereira, Paula Rodrigues; Mattos, Rômulo Medina de; Palmero, Celia Yelimar; Fortunato, Rodrigo S.; Gracelli, Jones Bernardes; Carvalho, Denise Pires de; Nasciutti, Luiz Eurico; Miranda-Alves, Leandro

doi:10.1530/endoabs.32.p499

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“…In accordance with our results, (Pereira et al, 2013 ) reported disorganization of follicular cell groups, with hypertrophy, hyperplasia of thyrocytes and glandular congestion compared with control thyroid gland. On the other hand, he found no changes in plasma levels of T 3 and T 4 after 15 days of treatment in his study.…”

Section: Discussionsupporting

confidence: 93%

The effect of Tributyltin on thyroid follicular cells of adult male albino rats and the possible protective role of green tea: a toxicological, histological and biochemical study

Dine

Nabil

Dwedar

2017

Egypt J Forensic Sci

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IntroductionTributyltin is one of the important and wide-spread persistent organic contaminants that accumulate in the food chain. It is suspected to cause endocrine-disrupting effects in mammals, due in part to its possible transfer through marine food chains and to the consumption of contaminated seafood.Aim of the workWas to study the possible toxic effect of Tributyltin on thyroid follicular cells of adult male albino rats and to evaluate the possible protective role of green tea.Material and methodsForty-five adult male albino rats were included and randomly divided into 3 equal groups: a control group (Group I); Group II: received tributyltin chloride (TBT) dissolved in corn oil orally in a dose of 5 mg/kg for 30 days. Group III: received tributyltin chloride in the same dose with concomitant oral administration of green tea extract for 30 days. At the end of the experiment, the animals were sacrificed and blood samples were subjected to hormonal assay for T3, T4 and TSH levels. Malondialdehyde and reduced glutathione were assessed. The thyroid tissue was processed for histological and ultrastructure examination. The colloid area of thyroid follicles was evaluated morphometrically and statistically analyzed.ResultsA significant decrease in T3 and T4 levels and serum reduced glutathione in the group II when compared with the other groups. Furthermore, a significant increase in serum Malondialdehyde and TSH levels was recorded in group II treated group by comparison to the other two groups. Histopathological and ultrastructural changes of thyroid gland follicles were detected in tributyltin treated rats; the follicular cells appeared swollen and vacuolated. Epithelial stratification was noticed in some foci with excessive vacuolation of the colloid. Dilated rough endoplasmic reticulum filled with flocculent material and increased number of lysosomes were also detected together with variation in shape and size of the nuclei. A marked improvement in the histological features of thyroid follicles was noticed in group III.ConclusionTributyltin induces oxidative stress in rats as well as anti-thyroid effect. The green tea extract is useful in combating tissue injury that is a result of tributyltin toxicity.

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Section: Discussionsupporting

confidence: 93%