Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus Trichoderma sp. Z43

Abstract

Six new lipids, trichoderols B-G (1–6), along with a known one, triharzianin B (7), were isolated from the culture of Trichoderma sp. Z43 obtained from the surface of the marine brown alga Dictyopteris divaricata. Their structures and relative configurations were identified by interpretation of 1D/2D NMR and MS data. Compounds 1–7 were assayed for inhibiting the growth of three phytopathogenic fungi (Fusarium graminearum, Gaeumannomyces graminis, and Glomerella cingulata), four marine phytoplankton species (Amphidinium carterae, Heterocapsa circularisquama, Heterosigma akashiwo, and Prorocentrum donghaiense), and one marine zooplankton (Artemia salina). Compounds 1, 4, and 7 exhibited weak antifungal activities against three phytopathogenic fungi tested with MIC ≥ 64 μg/mL. All compounds displayed moderate antimicroalgal activity with IC50 ≥ 15 μg/mL and low toxicity to the brine shrimp Artemia salina.

A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine‐Alga‐Epiphytic Trichoderma sp. Z43

“…The strain information and fermentation of Trichoderma sp. Z43 as well as the extraction and preliminary purification of its culture were described previously [21] (there was an error on the date of algae collection in our previous report, and it was June 2018 rather than July 2018). Fr.…”