Trichomonas vaginalis

Robinson, Sue; Mirchandani, Gopi

doi:10.1016/0002-9378(65)90506-5

Cited by 24 publications

(2 citation statements)

References 1 publication

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“…In this meta-analysis, data from a sample of more than 200 000 was 1.48 (95% confidence interval, 0.78-2.79) for exposure to metronidazole during the first trimester. individuals could be pooled; and no relationship was found between birth defects and metronidazole exposure during In several studies [11][12][13][20][21][22][23] birth defects associated with metronidazole exposure during pregnancy were the first trimester of pregnancy. The studies included in this meta-analysis were all cohort described; since all of them were case-series lacking a control group, they were excluded from the meta-analysis (Table 2).…”

Section: Maternal Drug Use Was Assessed By the Attendant Doctormentioning

confidence: 99%

Is metronidazole teratogenic? A meta‐analysis

Carvajal

Diego

et al. 1997

Brit J Clinical Pharma

183

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Aim In order to assess whether the use of metronidazole during pregnancy is associated with a higher risk of congenital malformations, a meta-analysis was conducted. Methods All epidemiological studies (cohort and case-control) which estimate risk of congenital malformations after exposure to metronidazole during early pregnancy were included in the meta-analysis. To obtain a summary odds ratio, the MantelHaenszel method was used. A test to verify absence of heterogeneity was also performed. Results One unpublished case-control and four published cohort studies fulfilled the inclusion criteria and were not statistically heterogeneous. A summary odds ratio was calculated for metronidazole exposure during the first trimester: OR=1.08, 95% CI: 0.90-1.29, heterogeneity test x 2 =4.72, P=0.32. ConclusionsThis meta-analysis did not find any relationship between metronidazole exposure during the first trimester of pregnancy and birth defects.

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Section: Maternal Drug Use Was Assessed By the Attendant Doctormentioning

confidence: 99%

Is metronidazole teratogenic? A meta‐analysis

Carvajal

Diego

et al. 1997

Brit J Clinical Pharma

183

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“…Though several reports [7,8,10,11] on metronidazole treatment in pregnancy have been unable to find any teratogenic effect of the drug, only one study seems to have investigated the maternal-fetal passage of metronidazole in early pregnancy [2]. The present study was undertaken to measure the concentrations of metronidazole and its hydroxy metabolite (I) as that too possesses bacterial and mutagenic activity [5,9] in placental and fetal tissues and maternal plasma after therapeutic administration of the drug to women in their first trimester of pregnancy and to assess the placenta/ plasma and fetus/plasma ratios of drug concentrations.…”

Section: Introductionmentioning

confidence: 99%

Preliminary report

1984

Journal of Perinatal Medicine

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Concentrations of metronidazole and its hydroxy metabolite (I) were determined by a specific chromatographic method in blood, placenta and fetus from 10 women receiving oral metronidazole prior to legal first trimester abortion. In one woman given 2 g of metronidazole 9 hours before abortion, placenta and plasma levels were 6.6 micrograms/g and 13.4 micrograms/ml, respectively. The corresponding values for the hydroxy metabolite (I) were 1.8 micrograms/g and 5.6 micrograms/ml. In nine women receiving 400 mg metronidazole 1 hour before abortion, concentrations of metronidazole in plasma ranged from less than 0.1 to 9.4 micrograms/ml, in placenta from less than 0.1 to 6.3 micrograms/g, and in a fetal tissue from 1.9 to 3.0 micrograms/g. The concentrations of hydroxy metabolite (I) in plasma and placenta and fetal tissue all ranged below those of metronidazole.

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Interventions for treating trichomoniasis in women

Forna

Gülmezoglu

2003

Cochrane Database of Systematic Reviews

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Trichomonas vaginalis

Cited by 24 publications

References 1 publication

Is metronidazole teratogenic? A meta‐analysis

Is metronidazole teratogenic? A meta‐analysis

Preliminary report

Interventions for treating trichomoniasis in women

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