Trichostatin A and Herboxidiene Up-regulate the Gene Expression of Low Density Lipoprotein Receptor.

Koguchi, Yutaka; Nishio, Maki; Kotera, Jun; Omori, Kenji; Ohnuki, Takashi; Komatsubara, Saburo

doi:10.7164/antibiotics.50.970

Cited by 34 publications

(29 citation statements)

References 8 publications

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“…There are several reports in the literature describing induction of gene expression after application of TSA to cells. Thus, HDACs (Gray and Ekström, 1998;Dangond and Gullans, 1998), LDL-Receptor (Koguchi et al, 1997) and p21 waf1/cip1 (Sowa et al, 1997;Archer et al, 1998) have been shown to be induced by TSA. However, there are also mRNAs downregulated following treatment with histone deacetylase inhibitors.…”

Section: Introductionmentioning

confidence: 97%

Trichostatin A Modulates Expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in Human Lung Adenocarcinoma Cells

Eickhoff

Rüller²,

Laue³

et al. 2000

Biological Chemistry

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Lung adenocarcinoma cells treated for 16 h with trichostatin A (TSA), an inhibitor of histone deacetylases, and untreated cells were analyzed with respect to differential gene expression. Complex hybridization of cDNA arrays revealed repression of Bcl-xL, CRAB2 and TFIID/TAFII31 as well as induction of p21waf1/cip1, GATA-2, hsp86, ID1, ID2 and ID3 mRNA expression, which could be verified by Northern blotting. ID2 induction was further confirmed by Taqman realtime quantitative RT-PCR. The described alterations of gene expression due to TSA renders the lung adenocarcinoma cells susceptible to induction of apoptosis.

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Section: Introductionmentioning

confidence: 97%

Trichostatin A Modulates Expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in Human Lung Adenocarcinoma Cells

Eickhoff

Rüller²,

Laue³

et al. 2000

Biological Chemistry

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“…1A) was isolated from Streptomyces chromofuscus A7847 (ATCC 49982) as a novel polyketide which selectively and effectively controls several annual weed species (10,16). Later, compound 1 was found to effectively reduce plasma cholesterol and possess stronger low-density lipoprotein receptor upregulation activity than tricholstatin A and TMC-49A, representing a new type of anticholesterol molecule (13). Additionally, it also has strong cytotoxic activities and induces both G 1 and G 2 /M arrest in human tumor cell line WI-38 (50% inhibitory concentrations range from 3.7 nM to 0.99 M) (9,23).…”

mentioning

confidence: 99%

Identification of the Herboxidiene Biosynthetic Gene Cluster in Streptomyces chromofuscus ATCC 49982

Shao

Zeng

et al. 2012

Appl Environ Microbiol

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“…Herboxidiene, a microbial secondary metabolite, originally isolated from Streptomyces chromofuscus A7847, has been shown to possess several biological properties including herbicidal, anticholesterol, and antitumor activities (Isaac et al 1992;Koguchi et al 1997;Sakai et al 2002a, b). However, to the best of our knowledge, no evaluation of the antiangiogenic activity of herboxidiene has been reported to date.…”

Section: Discussionmentioning

confidence: 98%

Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α

et al. 2015

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Antiangiogenesis is now thought of as one of the most important approaches for anticancer therapy. In this study, we determined the antiangiogenic property of herboxidiene, a polyketide natural product. Herboxidiene effectively inhibited the proliferation of human umbilical vein endothelial cells (HUVECs) at concentrations not exhibiting cytotoxicity. Furthermore, the natural product significantly suppressed vascular endothelial growth factor-induced invasion and tube formation in HUVECs as well as neovascularization of the chorioallantoic membrane in developing chick embryos. We also identified an association between the antiangiogenic activity of herboxidiene and the downregulation of both the phosphorylation of VEGF receptor 2 (KDR/Flk-1) and the expression of hypoxia-inducible factor-1α at the transcriptional level. These results suggest that herboxidiene functions as a potential antiangiogenic agent and may be applicable for anticancer therapy by targeting tumor angiogenesis.

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Trichostatin A and Herboxidiene Up-regulate the Gene Expression of Low Density Lipoprotein Receptor.

Cited by 34 publications

References 8 publications

Trichostatin A Modulates Expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in Human Lung Adenocarcinoma Cells

Trichostatin A Modulates Expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in Human Lung Adenocarcinoma Cells

Identification of the Herboxidiene Biosynthetic Gene Cluster in Streptomyces chromofuscus ATCC 49982

Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α

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