Triclabendazole in the treatment of established human fascioliasis

Abstract

The tolerance and efficacy of triclabendazole CGP 23030, specially prepared for human use, were assessed in 50 patients in the chronic phase of fascioliasis. After clinical examination, investigation and ultrasonography of the liver and biliary system, triclabendazole 10 mg/kg, either as a single or split dose, was administered. The clinical picture was studied daily for six days and the investigations were repeated 6, 30 and 60 days after treatment. The drug was tolerated. Its side-effects, which included upper abdominal pain, mild fever and limited derangement of liver function, were considered negligible. The cure rate at 2 months was 94% when assessed by the disappearance of eggs in stools and 88% when assessed by both the absence of eggs in stools and of worms in the biliary system. The use of triclabendazole for the treatment of human fascioliasis was found to be justified

Veterinary deworming agent-induced toxic optic neuropathy: a case report

“…Since retinal hemorrhage, exudation, and optic disc edema, were not seen upon fundoscopy and optic nerve changes were not found MRI of the cranium and orbital, drug-induced toxic optic neuropathy was considered. Even though serious adverse reactions to triclabendazole and bithionol have not been reported clinically thus far [ 4 , 8 , 9 ], there have been no studies of the use of these drugs in patients with hepatic and renal insufficiency [ 5 ]. Since triclabendazole and bithionol are metabolized by the liver [ 10 ], the synergistic effects of underlying cirrhosis and alcohol use may have increased the toxicity of these two drugs.…”