Triclosan

Bhutani, Tina; Jacob, Sharon E.

doi:10.1111/j.1524-4725.2009.01151.x

Cited by 26 publications

(2 citation statements)

References 11 publications

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“…34 Isolated case reports have been published on ACD from triclosan exposure, [35][36][37][38][39][40] rarely presenting as antimicrobial suture use. [41][42][43][44] To our knowledge, such a case of CIED-related allergic contact dermatitis to triclosan-coated suture has not previously been published.…”

Section: Discussionmentioning

confidence: 99%

Triclosan Allergy Mimicking Recurrent CIED Infections

Crossley,

Kowal,

Bloch

et al. 2023

Preprint

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An 80-year-old man had a secondary prevention defibrillator in place for treatment of sustained ventricular tachycardia. After a generator replacement several years later, he developed a series of apparent pulse generator infections requiring extraction. Each purulent appearing pocket eruption was culture negative. Eventually, he was diagnosed with a delayed hypersensitivity reaction to triclosan, an antibacterial that is commonly impregnated in surgical sutures. The evaluation for this is difficult and can be misleading. This entity should be considered in the differential diagnosis of patients with culture negative CIED infections.

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Section: Discussionmentioning

confidence: 99%

Triclosan Allergy Mimicking Recurrent CIED Infections

Crossley,

Kowal,

Bloch

et al. 2023

Preprint

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“…There have been reports on several suspected cases of allergic contact dermatitis towards triclosan-coated sutures, none of which could be verified [15]. …”

Section: Methodsmentioning

confidence: 99%

Prevention of abdominal wound infection (PROUD trial, DRKS00000390): study protocol for a randomized controlled trial

Heger

Voss

Knebel

et al. 2011

Trials

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BackgroundWound infection affects a considerable portion of patients after abdominal operations, increasing health care costs and postoperative morbidity and affecting quality of life. Antibacterial coating has been suggested as an effective measure to decrease postoperative wound infections after laparotomies. The INLINE metaanalysis has recently shown the superiority of a slowly absorbable continuous suture for abdominal closure; with PDS plus® such a suture has now been made available with triclosan antibacterial coating.Methods/DesignThe PROUD trial is designed as a randomised, controlled, observer, surgeon and patient blinded multicenter superiority trial with two parallel groups and a primary endpoint of wound infection during 30 days after surgery. The intervention group will receive triclosan coated polydioxanone sutures, whereas the control group will receive the standard polydioxanone sutures; abdominal closure will otherwise be standardized in both groups. Statistical analysis is based on intention-to-treat population via binary logistic regression analysis, the total sample size of n = 750 is sufficient to ensure alpha = 5% and power = 80%, an interim analysis will be carried out after data of 375 patients are available.DiscussionThe PROUD trial will yield robust data to determine the effectiveness of antibacterial coating in one of the standard sutures for abdominal closure and potentially lead to amendment of current guidelines. The exploration of clinically objective parameters as well as quality of life holds immediate relevance for clinical management and the pragmatic trial design ensures high external validity.Trial RegistrationThe trial protocol has been registered with the German Clinical Trials Register (DRKS00000390).

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Inhibition of streptococcal biofilm formation by Aronia by extracellular RNA degradation

Lee

Hong

2020

J Sci Food Agric

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BACKGROUND: The accumulation of oral bacterial biofilms is one of the primary etiological factors for oral diseases. Aronia melanocarpa extracts display general health benefits, including antimicrobial activities. This study evaluates the inhibitory effect of Aronia juice on oral streptococcal biofilm formation.RESULTS: Exposure to 1/10-diluted Aronia juice for 1 min significantly decreased in vitro streptococcal biofilm formation (P < 0.001). No remarkable difference was noted in streptococcal growth by Aronia under the same conditions. Interestingly, 1 week of oral rinse with diluted Aronia juice led to significantly fewer salivary streptococcal colony-forming units (CFUs) relative to oral rinsing with tap water (P < 0.05). Furthermore, Aronia exerted an extracellular RNA-degrading effect, and RNase inhibitor alleviated Aronia-dependent streptococcal biofilm inhibition.CONCLUSION: Aronia might inhibit initial biofilm formation by decomposing extracellular RNA, which plays an important role in bacterial biofilm formation. Our data suggest that oral rinsing with Aronia juice will aid in treating oral biofilm-dependent diseases easily and efficiently.

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Triclosan

Cited by 26 publications

References 11 publications

Triclosan Allergy Mimicking Recurrent CIED Infections

Triclosan Allergy Mimicking Recurrent CIED Infections

Prevention of abdominal wound infection (PROUD trial, DRKS00000390): study protocol for a randomized controlled trial

Inhibition of streptococcal biofilm formation by Aronia by extracellular RNA degradation

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