Triclosan, an antibacterial agent, increases intracellular Zn2+ concentration in rat thymocytes: Its relation to oxidative stress

Tamura, Ikumi; Kanbara, Yasuhiro; Saito, Minoru; Horimoto, Kanna; Satoh, Masaya; Yamamoto, Hiroshi; Oyama, Yasuo

doi:10.1016/j.chemosphere.2011.09.009

Cited by 53 publications

(28 citation statements)

References 43 publications

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“…Our previous data had shown that 8-OHdG inhibitor NAC mitigated TCSmediated decrease of GDM in HepG2 cells (Ma et al, 2013). In this study we found that 8-OHdG increased in low-dose TCS exposed HepG2 cells, suggesting that the low-dose TCS induced oxidative stress (Tamura et al, 2012), also the methylation levels of LINE-1 gene data supported that 8-OHdG decrease may impair global DNA hypomethylation. In summary, we believe that the increased 8-OHdG levels played an indirect role in inducing genomic hypomethylation in TCS exposed HepG2 cells.…”

Section: Discussionsupporting

confidence: 73%

LINE-1 gene hypomethylation and p16 gene hypermethylation in HepG2 cells induced by low-dose and long-term triclosan exposure: The role of hydroxyl group

Zeng

Pan

et al. 2016

Toxicology in Vitro

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Section: Discussionsupporting

confidence: 73%

LINE-1 gene hypomethylation and p16 gene hypermethylation in HepG2 cells induced by low-dose and long-term triclosan exposure: The role of hydroxyl group

Zeng

Pan

et al. 2016

Toxicology in Vitro

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“…A recent study shows that TCS can act as H 2 O 2 by decreasing the contents of intracellular thiol, contributing to oxidative stress, which may damage genomic DNA to accumulate 8-OHdG in the genomic DNA (Tamura et al, 2012). Indeed, a previous study has suggested that 8-OHdG can inhibit the formation of 5mdC in CpG dinucleotides (Valinluck et al, 2004).…”

Section: Effects Of Tcs On the Levels Of 8-ohdg Accumulated In Genomimentioning

confidence: 99%

Triclosan reduces the levels of global DNA methylation in HepG2 cells

Zheng

et al. 2013

Chemosphere

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“…Other compounds, such as triclosan (Tamura et al, 2012) and potentially paraquat and irgarol (Walker et al, 2008), can cause an increase in the intracellular concentration of free zinc(II) and illicit gene expression via the MTF1 pathway.…”

Section: Reviewmentioning

confidence: 99%

“…For example, the promoter region of rainbow trout MT-A possesses six MREs, four of which are arranged in tandem (Olsson et al, 1995), and MT-B possesses four MREs (Samson and Gedamu, 1995). Metals may displace Zn from metal binding sites within the cell, increasing intracellular free zinc and inducing MT expression.Other compounds, such as triclosan (Tamura et al, 2012) and potentially paraquat and irgarol (Walker et al, 2008), can cause an increase in the intracellular concentration of free zinc(II) and illicit gene expression via the MTF1 pathway. …”

mentioning

confidence: 99%

Gill cell culture systems as models for aquatic environmental monitoring

Bury

Schnell

Högstrand

2014

Journal of Experimental Biology

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A vast number of chemicals require environmental safety assessments for market authorisation. To ensure acceptable water quality, effluents and natural waters are monitored for their potential harmful effects. Tests for market authorisation and environmental monitoring usually involve the use of large numbers of organisms and, for ethical, cost and logistic reasons, there is a drive to develop alternative methods that can predict toxicity to fish without the need to expose any animals. There is therefore a great interest in the potential to use cultured fish cells in chemical toxicity testing. This review summarises the advances made in the area and focuses in particular on a system of cultured fish gill cells grown into an epithelium that permits direct treatment with water samples. KEY WORDS: FIGCS, Biomonitoring, Environmental risk assessment, Fish, In vitro, Toxicology IntroductionThe Industrial Revolution caused a rapid rise in the use of raw materials and urbanisation as the populace moved to the cities for employment. Since this time, there has been a continuous increase in living standards that to a large part has been fuelled by innovations within the chemical and pharmaceutical industry. Life expectancy has increased as a result of great advances in medical practices and effective drugs against many fatal diseases. The increase in life expectancy has seen the population of the world grow, reaching 7 billion in 2012, and to feed this population there have been great advances in agricultural productivity partly via the development of pesticides and nitrate/phosphate-based fertilisers. These activities have altered the geochemical cycling of elements, increasing or decreasing concentrations in earth system compartments and increasing global distribution (Doney, 2010). Anthropogenic activities have left a cumulative and lasting impression on the biosphere -so much so that geologists have termed the current epoch the anthropocene (Zalasiewicz et al., 2010).The increase in agricultural and industrial production and consumption of raw materials has resulted in the creation of vast amounts of waste that enters the aquatic ecosystem. An acknowledgement of the decline in environmental quality due to contaminants has led to the development of environmental quality standards (EQS) in many countries, and to assess whether these standards are being adhered to, many jurisdictions also have a programme of waste water effluent testing (WET) and/or biomonitoring. The EQS are derived from toxicity tests that use numerous organisms per compound, and in order to set standards several species are tested. In the USA ~3 million fish are used in WET procedures (see Tanneberger et al., 2013). There is a move towards reducing the number of animals used in research and toxicology studies and there are a number of international initiatives aimed at investigating the 3Rs -reduction, replacement and refinement -in animal research (for example, see http://www.nc3rs.org.uk/). Within the context of the need to determine EQS fo...

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Triclosan, an antibacterial agent, increases intracellular Zn2+ concentration in rat thymocytes: Its relation to oxidative stress

Cited by 53 publications

References 43 publications

LINE-1 gene hypomethylation and p16 gene hypermethylation in HepG2 cells induced by low-dose and long-term triclosan exposure: The role of hydroxyl group

LINE-1 gene hypomethylation and p16 gene hypermethylation in HepG2 cells induced by low-dose and long-term triclosan exposure: The role of hydroxyl group

Triclosan reduces the levels of global DNA methylation in HepG2 cells

Gill cell culture systems as models for aquatic environmental monitoring

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