Triclosan elevates estradiol levels in serum and tissues of cycling and peri-implantation female mice

Pollock, Tyler; Greville, Lucas J.; Tang, B. Y.; deCatanzaro, Denys

doi:10.1016/j.reprotox.2016.09.004

Cited by 30 publications

(21 citation statements)

References 55 publications

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“…The morphometric analysis of the uterine structure of the offspring showed that all the groups exposed to TCS showed an increase in the thickness of the uterine layers. Studies have shown that TCS modulates the exogenous and endogenous estrogen concentration, for the ability to bind estrogen receptor subtypes ERα and ERβ . Exposure to TCS induces estrogenic effects by direct activation of the estrogen receptor, or by altering a coactivator of the binding receptor interaction to increase steroid response .…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that TCS modulates the exogenous and endogenous estrogen concentration, for the ability to bind estrogen receptor subtypes ERα and ERβ . Exposure to TCS induces estrogenic effects by direct activation of the estrogen receptor, or by altering a coactivator of the binding receptor interaction to increase steroid response . TCS also potentially increases the action of estrogen by decreasing catabolism, inhibiting the activity of the enzyme hepatic sulfotransferase .…”

Section: Discussionmentioning

confidence: 99%

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Maternal exposure to triclosan causes fetal development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring

Bitencourt

Fortunato

Amorim

2019

Environmental Toxicology

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The aim of the present study was to evaluate the effects of maternal exposure to triclosan (TCS) during pregnancy and lactation on the uterine morphology of rat offspring. For this, 32 Wistar rat dams were distributed into four dose groups (eight mothers per group), and gavage daily, throughout pregnancy and lactation, as follows: Group I–control (GI): corn oil; Group II (GII): TCS diluted in corn oil at a dose of 75 mg/kg/d; Group III (GIII): TCS diluted in corn oil at a dose of 150 mg/kg/d; Group IV (GIV): TCS diluted in corn oil at a dose of 300 mg/kg/d. A female pup of each mother was selected, and at 90 days the pups were euthanized for weighing and collection of the uterus for histomorphometric analysis. The results showed that the mean litter weight was minor in all the groups treated with TCS, when compared with control. The levels thyroid hormones thyroxine (T4) and triiodothyronine (T3) in TCS mother rats were reduced; however the levels of thyroid stimulating hormone (TSH) were increases. The offspring of all groups exposed to TCS presented deregulation of the estrous cycle, compared with control. Analysis of the uterine histological structure demonstrated that all layers of the uterus were affected by the administration of TCS, and the morphometric analysis showed increased uterine layers thickness in the treated groups. We concluded that maternal exposure to TCS during pregnancy and lactation causes intrauterine development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Maternal exposure to triclosan causes fetal development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring

Bitencourt

Fortunato

Amorim

2019

Environmental Toxicology

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“…However, no change on ovary histopathology or follicular development was observed (18). Additionally, elevated urinary concentrations of endogenous estradiol have been detected following subcutaneous injection of triclosan in cycling and inseminated female CF1 mice (36). Similarly, higher doses of triclosan may cause disruption of intrauterine blastocyst implantation in these mice (19).…”

Section: Discussionmentioning

confidence: 99%

Urinary triclosan concentrations and diminished ovarian reserve among women undergoing treatment in a fertility clinic

Mínguez-Alarcón

Christou

Messerlian

et al. 2017

Fertility and Sterility

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Objective To investigate the association between urinary triclosan concentrations and antral follicle count (AFC), a well-accepted marker of ovarian reserve, among women from a fertility center. Design Prospective cohort study. Setting Women attending the Massachusetts General Hospital Fertility Center. Patient(s) A total of 109 women. Intervention(s) None. Urinary triclosan concentrations were quantified by online solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry. Main outcomes measure(s) AFC through transvaginal ultrasonography on the 3rd day of an unstimulated menstrual cycle or on the 3rd day of a progesterone withdrawal bleed. Results The geometric mean (GM) (95% CI) of the specific gravity (SG)-adjusted urinary triclosan concentrations for the 225 samples provided by the 109 women was 13.0 (8.9, 19.1) μg/L. Women had median (interquartile range, IQR) AFC of 13 (8, 18). SG-adjusted urinary triclosan concentrations were inversely associated with AFC (-4%, 95% CI= -7%, -1%, p-value=0.009). Women with triclosan concentrations above the median had lower AFC compared to those with triclosan concentrations equal to or below the median, with an adjusted difference of -3.2 (95% CI -3.9, -1.6) among those with body mass index (BMI)<25 kg/m2 and -1.8 (95% CI -3.2, -0.3) among those who were <35 years old. Conclusion(s) SG-adjusted urinary triclosan concentrations were inversely associated with AFC in women seeking care at a fertility center. This association was modified by age and BMI, with younger and leaner women showing larger decreases in AFC.

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“…Animals were killed by cardiac perfusion with 20 ml saline. Following procedures previously described (deCatanzaro & Pollock, ; Pollock et al ., , ), samples of the heart, lungs, muscle from the hind leg, abdominal adipose, uterus, ovaries, liver and a cross‐section of the kidney encompassing the medulla and cortex were obtained and placed in pre‐weighed scintillation vials. Following tissue collection, vials were re‐weighed to measure the wet mass of each tissue.…”

Section: Methodsmentioning

confidence: 99%

“…This could occur similarly to actions of triclosan, another endocrine disruptor with low affinity for ERs that nevertheless can impede blastocyst implantation in mice (Crawford & deCatanzaro, ). Triclosan administration increases endogenous urinary E 2 and concentration of exogenous 3 H–E 2 in the uterus of female mice (Pollock et al ., ). Triclosan also increases 14 C–BPA concentration in reproductive tissues of mice, most likely via interference with conjugating enzymes (Pollock et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Diethylhexyl phthalate magnifies deposition of ¹⁴ C-bisphenol A in reproductive tissues of mice

et al. 2017

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Endocrine disrupting chemicals are found in diverse common products, including cosmetics, food packaging, thermal receipt paper and plastic containers. This exposes most people in developed countries through ingestion, skin absorption and inhalation. Two ubiquitous endocrine disrupting chemicals, bisphenol A (BPA) and diethylhexyl phthalate (DEHP) can interact in disrupting blastocyst implantation in inseminated females. We hypothesized that DEHP might increase the bioavailability of BPA in tissues by competing for metabolic enzymes. We injected 0, 3, 9 or 18 mg DEHP into female and male mice and allowed 30 min for the chemical to circulate before giving them a food supplement containing 50 μg kg C-BPA. Animals were dissected 1 h following C-BPA administration and various tissue samples were acquired. Samples were solubilized and radioactivity was measured via liquid scintillation counting. In cycling females, DEHP increased BPA deposition in the muscle, uterus, ovaries and blood serum relative to controls. In peri-implantation females, DEHP increased deposition of BPA in the uterus, ovaries and serum relative to controls. In males, DEHP doses increased BPA deposition in serum and epididymis relative to controls. These results are consistent with the hypothesis that DEHP competes with BPA for conjugating enzymes such as UDP-glucuronosyltransferase, thereby magnifying the presence of BPA in estrogen-binding reproductive tissues. Copyright © 2017 John Wiley& Sons, Ltd.

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Triclosan elevates estradiol levels in serum and tissues of cycling and peri-implantation female mice

Cited by 30 publications

References 55 publications

Maternal exposure to triclosan causes fetal development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring

Maternal exposure to triclosan causes fetal development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring

Urinary triclosan concentrations and diminished ovarian reserve among women undergoing treatment in a fertility clinic

Diethylhexyl phthalate magnifies deposition of ¹⁴ C-bisphenol A in reproductive tissues of mice

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Triclosan elevates estradiol levels in serum and tissues of cycling and peri-implantation female mice

Cited by 30 publications

References 55 publications

Maternal exposure to triclosan causes fetal development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring

Maternal exposure to triclosan causes fetal development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring

Urinary triclosan concentrations and diminished ovarian reserve among women undergoing treatment in a fertility clinic

Diethylhexyl phthalate magnifies deposition of 14 C-bisphenol A in reproductive tissues of mice

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Diethylhexyl phthalate magnifies deposition of ¹⁴ C-bisphenol A in reproductive tissues of mice