Tricyclic antidepressants, thyroid function, and their relationship with the behavioral responses in rats

Massol, Jacques; Martin, Patrick; Chatelain, F; Puech, Alain J.

doi:10.1016/0006-3223(90)90062-7

Cited by 15 publications

(6 citation statements)

References 33 publications

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“…Our findings largely confirm other reports that have examined thyroid function changes in depressed adults receiving antidepressant treatment, including clomipramine and desipramine (Schlienger et al 1980;Brady and Anton 1989). Our data and those of others is mostly in agreement with animal studies that have noted reduced thyroid hormones (Massol et al 1990) and TSH (Mueller et al 1976) following chronic treatment with tricyclic antidepressants, including clomipramine (Massol et al 1990). However, these effects are also somewhat selective, in that a reduction in T3 and TSH was observed in the absence of a significant change in T4.…”

Section: Elevated Thyroid Indices In Ocd 585supporting

confidence: 95%

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Elevated Thyroid Indices in Children and Adolescents with Obsessive-Compulsive Disorder: Effects of Clomipramine Treatment

McCracken

Hanna

2005

Journal of Child and Adolescent Psychopharmacology

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Section: Elevated Thyroid Indices In Ocd 585supporting

confidence: 95%

“…While some reports have noted decreases in T3 induced by clomipramine in depressed adult patients (Schlienger et al 1981) and in rats (Massol et al 1990), to our knowledge this is the first description of the effects of clomipramine on thyroid indices in patients with obsessive-compulsive disorder (OCD).…”

Section: Elevated Thyroid Indices In Ocd 585mentioning

confidence: 92%

Elevated Thyroid Indices in Children and Adolescents with Obsessive-Compulsive Disorder: Effects of Clomipramine Treatment

McCracken

Hanna

2005

Journal of Child and Adolescent Psychopharmacology

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“…Impaired escape behaviour in LH protocols is defined by comparison to a separate group that undertakes the active avoidance test without prior exposure to inescapable stress (e.g. refs 23, 24, 25, 26). This group is referred to as the Learning Control (LC) group, as it serves to verify that rats not previously stressed can in fact learn the avoidance task (N = 10).…”

Section: Methodsmentioning

confidence: 99%

Strong interactions between learned helplessness and risky decision-making in a rat gambling model

Nóbrega

Hedayatmofidi

Lobo

2016

Sci Rep

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Risky decision-making is characteristic of depression and of addictive disorders, including pathological gambling. However it is not clear whether a propensity to risky choices predisposes to depressive symptoms or whether the converse is the case. Here we tested the hypothesis that rats showing risky decision-making in a rat gambling task (rGT) would be more prone to depressive-like behaviour in the learned helplessness (LH) model. Results showed that baseline rGT choice behaviour did not predict escape deficits in the LH protocol. In contrast, exposure to the LH protocol resulted in a significant increase in risky rGT choices on retest. Unexpectedly, control rats subjected only to escapable stress in the LH protocol showed a subsequent decrease in riskier rGT choices. Further analyses indicated that the LH protocol affected primarily rats with high baseline levels of risky choices and that among these it had opposite effects in rats exposed to LH-inducing stress compared to rats exposed only to the escape trials. Together these findings suggest that while baseline risky decision making may not predict LH behaviour it interacts strongly with LH conditions in modulating subsequent decision-making behaviour. The suggested possibility that stress controllability may be a key factor should be further investigated.

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“…A concomitant increase in serum TSH concentration would be expected in response to the decrease in serum TT4 and fT4 concentrations, but no change was found in the serum TSH concentration, both basal and 30 minutes post‐TRH administration 65 . This finding may provide evidence for clomipramine‐induced suppression of TSH secretion, as occurs in rats and humans 139,142 …”

Section: Effects Of Drugs On Thyroid Functionmentioning

confidence: 79%

Influence of medications on thyroid function in dogs: An update

Bolton

Panciera

2023

Veterinary Internal Medicne

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Erroneous thyroid function test results can occur because of drugs that alter thyroid hormone physiology in one or more aspects, including synthesis, secretion, distribution, and metabolism. Research since publication of the last review in the Journal of Veterinary Internal Medicine (JVIM) 20 years ago has evaluated the effects of amiodarone, zonisamide, inhalant anesthetics, clomipramine, trilostane, and toceranib on thyroid function tests in the dog. In addition, recent work on the effects of glucocorticoids, sulfonamides, phenobarbital, and nonsteroidal anti‐inflammatory drugs will be reviewed. Awareness of these effects is necessary to avoid misdiagnosis of hypothyroidism and unnecessary treatment.

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Tricyclic antidepressants, thyroid function, and their relationship with the behavioral responses in rats

Cited by 15 publications

References 33 publications

Elevated Thyroid Indices in Children and Adolescents with Obsessive-Compulsive Disorder: Effects of Clomipramine Treatment

Elevated Thyroid Indices in Children and Adolescents with Obsessive-Compulsive Disorder: Effects of Clomipramine Treatment

Strong interactions between learned helplessness and risky decision-making in a rat gambling model

Influence of medications on thyroid function in dogs: An update

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