Triglyceride Glucose Index Was a Predictor of 6-Month Readmission Caused by Pulmonary Infection of Heart Failure Patients

Abstract

Objectives. Insulin resistance is associated with the prognosis of heart failure (HF) patients. The triglyceride glucose (TyG) index is a simple marker of insulin resistance. However, it remains unclear whether the TyG index is associated with the incidence of readmission in patients with HF. Methods. We enrolled 901 patients with completed records on serum triglyceride and glucose in our study. The TyG index was calculated as log (fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2). There were 310 cases of readmission and the average TyG index was 7.8 ± 0.7. Restricted cubic spline was fitted to explore the linearity of TyG index associating with 6-month readmission of HF patients. Logistic regression analysis was performed to explore the association between TyG index quartile and the incidence of 6-month readmission. Results. Only the 6-month readmission was significantly different among TyG quartiles, and it was the highest (41.9%) in the lowest quartile (ranging 6.17∼7.36). the TyG index was nonlinearly associated with 6-month readmission ( p for nonlinearity = 0.009), with the lower level of TyG index increasing the risk of 6-month readmission. Besides, multivariable logistic analysis showed that the lowest TyG quartile was associated with a higher incidence of 6-month readmission in the unadjusted model (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.18–2.57; p = 0.005 ), partially adjusted model (OR 1.82, 95%CI 1.22–2.72; p = 0.004 ), and fully-adjusted model (OR 1.65, 95%CI 1.09–2.45; p = 0.024 ). The association was consistent across gender and diabetes group. Conclusion. A lower TyG index independently increased the risk of 6-month readmission in HF patients, which could be a prognostic factor in heart failure.

Triglyceride-glucose index and heart failure: a systematic review and meta-analysis

“…Next, Huang et al [31], in their study, included patients with ADHF and found a significantly higher prevalence of LVEF ≤ 40% in the T3 of the TyG index (≥ 9.32) compared with lower T (T1 [< 8.83] and T2 [8.83-9.32]). Shi et al [39] found significantly different LVEF levels among quartiles of TyG in patients with HF, while the observed trend was U-shaped (higher in the Q1 and Q4 of the TyG index). Finally, Sun et al [41] compared LVEF among Q of the TyG index in patients with ischemic HF who underwent elective PCI and found no significant difference among these groups (P = 0.187).…”

“…Further, Guo et al [13] found that in patients with CHF and T2DM, the incidence of rehospitalization due to HF in the T3 group was significantly higher than that observed in the T1 group (HR 1.84, 95% CI 1.16 to 2.91). Finally, Shi and colleagues [39], in 901 HF patients, examined the usage of the TyG index as a predictor of the incidence of readmission of HF patients. To this aim, they divided patients into four Q (Q1 to Q4) based on the TyG index and, surprisingly, found that a lower TyG index (< 7.36) independently augmented the risk of 6-month readmission (P = 0.024).…”

“…Five studies included patients with HF and compared LVEF between groups of patients classified based on the TyG index as a cut-off [13,17,31,39,41]. Cheng et al [17] found comparable LVEF values between low-TyG (TyG ≤ 9.44) and high-TyG (TyG > 9.44) groups in nondiabetic patients with AHF (P = 0.169).…”

Association between triglyceride glucose-body mass index and long-term adverse outcomes of heart failure patients with coronary heart disease

“…The TyG index, a combination of these two indicators, still has limited predictive performance in our study. Some cohort studies have shown a nonlinear relationship between the TyG index and the risk of HF rehospitalization [ 59 , 60 ]. Our study observed a similar trend (Additional file, Figure S3 b).…”