Triglycerides and total serum cholesterol in rotator cuff tears: do they matter?

Longo, Umile Giuseppe; Franceschi, Francesco; Spiezia, Filippo; Forriol, Francisco; Maffulli, Nicola; Denaro, Vincenzo

doi:10.1136/bjsm.2008.056440

Cited by 82 publications

(75 citation statements)

References 35 publications

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“…Group 2 (control group) included 169 patients (115 men and 54 women; mean age: 61 years, range 26-86) who underwent arthroscopic meniscectomy for a meniscal tear in the same period, and had no evidence of back pain [23,24]. These patients were frequency-matched by age (within 3 years) and gender with patients of Group 1 ( Table 1).…”

Section: Methodsmentioning

confidence: 99%

Symptomatic disc herniation and serum lipid levels

et al. 2011

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Insufficient blood supply to the intervertebral disc (IVD) has been proposed to play a role as causative factor in IVD degeneration. There is an association between IVD diseases and increased risk of dying of ischaemic heart disease. Obesity and tobacco are potential risk factors for degenerative IVD disease. High blood cholesterol and triglycerides serum levels are risk factors for atherosclerosis, and could be responsible for a decreased in the blood supply to the already poor vascularized IVD. We performed a frequency-matched casecontrol study to determine the serum levels of patients with symptomatic herniated lumbar disc. We examined the fasting serum lipid levels in 384 subjects who were operated at our institution. Group 1 included 169 consecutive patients (115 men and 54 women; mean age: 59.1 years, range 29-85) who underwent surgery for symptomatic disc herniation. Group 2 (control group) included 169 patients (115 men and 54 women; mean age: 61 years, range 26-86) who underwent arthroscopic meniscectomy for a meniscal tear in the same period. These patients were frequency-matched by age (within 3 years) and gender with patients of Group 1. Sera were extracted from blood samples and the concentrations of total cholesterol (TC) and triglycerides (TG) were determined. When comparing the two groups, patients with symptomatic herniated lumbar disc showed statistically significant higher triglyceride concentration (P = 0.02) and total cholesterol concentration (P = 0.01). Serum lipid levels may be a risk factor for IVD pathology. An enhanced understanding of these factors holds the promise of new approaches to the prevention and management of IVD pathology.

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Section: Methodsmentioning

confidence: 99%

Symptomatic disc herniation and serum lipid levels

et al. 2011

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“…Many studies were conducted in older populations with at least one analysis group >50 years of age (33)(34)(35)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60). The range of symptom duration varied substantially within and across studies.…”

Section: Secondary Screen-quality Assessment Overviewmentioning

confidence: 99%

“…Only 8 of the 44 studies reported insignificant findings throughout (33,38,46,48,51,58,67,68). Descriptions are provided below for the categories of biomarkers examined in >5 studies.…”

Section: Secondary Screen-quality Assessment Overviewmentioning

confidence: 99%

“…Seven studies investigated lipids and cholesterol using systemic sampling methods, ie, blood samples (33,35,41,43,46,48,77). Four observed statistically significant associations with MSD (35,41,43,77); three did not (33,46,48). Total cholesterol (TC) was examined in all seven studies.…”

Section: Continuedmentioning

confidence: 99%

“…Total cholesterol (TC) was examined in all seven studies. Two studies investigated rotator cuff tears (43,46), showing increased (43) or no difference in TC (46) among cases versus controls. Two studies investigated frozen shoulder (adhesive capsulitis), also with divergent results.…”

Section: Continuedmentioning

confidence: 99%

See 2 more Smart Citations

Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders

Gold¹,

Hallman²,

Hellström³

et al. 2015

Scand J Work Environ Health

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A statistically significant association between the musculoskeletal disorders (MSD) and biomarkers studied was demonstrated in 82% of sufficient quality articles. Evidence suggested that: collagen repair marker (TIMP-1) is decreased in fibroproliferative disorders; serotonin (5-HT) is increased in trapezius myalgia; triglycerides are increased in various MSD. Limitations in the articles include possible selection bias, confounding, spectrum effect, and insufficient attention to comorbid conditions.

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